Rho GTPase-Activating Protein 45

Preferred Label : Rho GTPase-Activating Protein 45;

NCIt synonyms : Minor Histocompatibility Antigen HA-1 Precursor; ARHGAP45; Minor Histocompatibility Protein HA-1 Precursor; Rho GTPase Activating Protein 45;

NCIt definition : Rho GTPase-activating protein 45 (1136 aa, 125 kDa) is encoded by the human ARHGAP45 gene. This protein is involved in the activation of Rho family GTPases.;

NCIt note : A variant form of Rho GTPase-activating protein 45 where the arginine at amino acid position 139 has been replaced by histidine is a precursor for the minor histocompatibility antigen peptide HA-1. This antigen is a factor in the occurrence of graft-versus-host disease (GVHD) in transplant patients.;

NCI Metathesaurus CUI : CL937248;

Details

Origin ID

C157546;

UMLS CUI

C4761536;

Automatic exact mappings (from CISMeF team)
- Rho GTPase activating protein 45 [HGNC gene]
OMIM relation
- Minor histocompatibility antigen ha-1 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- ARHGAP45 Gene [NCIt concept]
- Signaling Pathway Gene [NCIt concept]
gene_product_has_associated_anatomy
- Plasma Membrane [NCIt concept]
gene_product_has_gene_product_variant
- ARHGAP45 NP_036424.2:p.R139H [NCIt concept]
- ARHGAP45 Protein Variant [NCIt concept]
gene_product_has_structural_domain_or_motif
- Coiled-Coil Domain [NCIt concept]
- DAG/PE-Binding Domain [NCIt concept]
gene_product_plays_role_in_biological_process
- G Protein-Coupled Receptor Signaling [NCIt concept]
- Signal Transduction [NCIt concept]

Keyword's position in hierarchy(ies) :

You can consult :

recommendations
documents concerning education
documents for patients