Serine/Threonine-Protein Kinase A-Raf

Preferred Label : Serine/Threonine-Protein Kinase A-Raf;

NCIt synonyms : A-RAF Serine/Threonine-Protein Kinase; v-raf Murine Sarcoma 3611 Viral Oncogene Homolog 1; PKS2; RAFA1; PKS; ARAF1; Proto-Oncogene A-Raf-1; Proto-Oncogene Pks; EC 2.7.11.1; Proto-Oncogene A-Raf; A-RAF Protein Kinase; v-Raf Murine Sarcoma 3611 Viral Oncogene-Like Protein; A-Raf Proto-Oncogene Serine/Threonine-Protein Kinase;

NCIt definition : Serine/threonine-protein kinase A-Raf (606 aa, 68 kDa) is encoded by the human ARAF gene. This protein plays a role in protein phosphorylation, signal transduction and the negative regulation of apoptosis.;

Details

Origin ID

C18535;

UMLS CUI

C3853563;

OMIM relation
- Araf protooncogene, serine/threonine kinase [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- ARAF Gene [NCIt concept]
- Enzyme Gene [NCIt concept]
- Phosphotransferase Gene [NCIt concept]
- Serine/Threonine Protein Kinase Gene [NCIt concept]
- Transferase Gene [NCIt concept]
gene_product_has_biochemical_function
- Kinase [NCIt concept]
gene_product_has_organism_source
- Human [NCIt concept]
gene_product_has_structural_domain_or_motif
- DAG/PE-Binding Domain [NCIt concept]
- Substrate Interaction Domain [NCIt concept]
gene_product_is_element_in_pathway
- Actin Cytoskeleton Regulation Pathway [NCIt concept]
- Acute Myeloid Leukemia Pathway [NCIt concept]
- Bladder Cancer Pathway [NCIt concept]
- Chronic Myeloid Leukemia Pathway [NCIt concept]
- Colorectal Cancer Pathway [NCIt concept]
- ERBB Family Signaling Pathway [NCIt concept]
- Endometrial Cancer Pathway [NCIt concept]
- Glioblastoma Multiforme Pathway [NCIt concept]
- Insulin/Insulin Receptor Signaling Pathway [NCIt concept]
- Long-Term Depression Pathway [NCIt concept]
- Long-Term Potentiation Pathway [NCIt concept]
- Melanoma Pathway [NCIt concept]
- Natural Killer Cell-Mediated Cytotoxicity Pathway [NCIt concept]
- Non-Small Cell Lung Cancer Pathway [NCIt concept]
- Pancreatic Cancer Pathway [NCIt concept]
- Progesterone-Mediated Oocyte Maturation Pathway [NCIt concept]
- Prostate Cancer Pathway [NCIt concept]
- Renal Cell Carcinoma Pathway [NCIt concept]
- Vascular Smooth Muscle Contraction Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Cell Proliferation [NCIt concept]
- Phosphorylation Process [NCIt concept]
- Protein Phosphorylation Process [NCIt concept]
- Serine/Threonine Phosphorylation [NCIt concept]
- Signal Transduction [NCIt concept]
is_target
- Pan-RAF Inhibitor LY3009120 [NCIt concept]
- Tovorafenib [NCIt concept]

Keyword's position in hierarchy(ies) :

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