Protein Kinase C Iota Type

Preferred Label : Protein Kinase C Iota Type;

NCIt synonyms : PRKC-Lambda/Iota; PRKCI; EC 2.7.11.13; Atypical Protein Kinase C-Lambda/Iota; nPKC-Iota; aPKC-Lambda/Iota;

NCIt definition : Protein kinase C iota type (596 aa, 68 kDa) is encoded by the human PRKCI gene. This protein plays a role in serine/threonine phosphorylation.;

NCIt note : Protein kinase C iota type is necessary for BCL-ABL-mediated resistance to drug-induced apoptosis and protects leukemia cells against drug-induced apoptosis. (EntrezGene and UniProt); Protein kinase C iota type is an atypical PKC, meaning that the kinase activity is independent of calcium, phosphatidylserine, phorbol esters or diacylglycerol. (UniProt);

Details

Origin ID

C104803;

UMLS CUI

C1568202;

OMIM relation
- Protein kinase C, iota form [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- PRKCI protein, human [MeSH concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Enzyme Gene [NCIt concept]
- PRKCI Gene [NCIt concept]
- Phosphotransferase Gene [NCIt concept]
- Serine/Threonine Protein Kinase Gene [NCIt concept]
- Transferase Gene [NCIt concept]
gene_product_has_associated_anatomy
- Cytosol [NCIt concept]
gene_product_has_biochemical_function
- Kinase [NCIt concept]
- Protein Kinase C [NCIt concept]
gene_product_has_structural_domain_or_motif
- DAG/PE-Binding Domain [NCIt concept]
- Substrate Interaction Domain [NCIt concept]
gene_product_is_element_in_pathway
- Endocytosis Pathway [NCIt concept]
- Insulin/Insulin Receptor Signaling Pathway [NCIt concept]
- Tight Junction Assembly Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Cell Surface Extension [NCIt concept]
- Cytoskeletal Modeling [NCIt concept]
- Negative Regulation of Apoptosis [NCIt concept]
- Phosphorylation Process [NCIt concept]
- Protein Phosphorylation Process [NCIt concept]
- Serine/Threonine Phosphorylation [NCIt concept]
- Signal Transduction [NCIt concept]
- Transport Process [NCIt concept]
is_target
- Gold Sodium Thiomalate [NCIt concept]

Keyword's position in hierarchy(ies) :

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