Protein Kinase C

Preferred Label : Protein Kinase C;

NCIt synonyms : EC 2.7.11.13; Protein Kinase-C;

NCIt related terms : PKC;

NCIt definition : A family of serine/threonine protein kinases that have a structurally conserved catalytic subunit and a regulatory subunit that are connected by a hinge domain.;

Alternative definition : NCI-GLOSS: An enzyme found throughout the body's tissues and organs. Several forms of PKC are involved in many cellular functions. PKC is being studied in the treatment of cancer.;

NCIt note : There are 3 classes of protein kinase C isozymes based on the molecular requirement for activation. Conventional isozymes need calcium ions, diacylglycerol and phospholipids for activation. Novel isozymes require diacylglycerol and are not regulated by calcium ions, while atypical isozymes require neither diacylglycerol nor calcium ions.;

Codes from synonyms : CDR0000318824; CDR0000403142;

Details

Origin ID

C17017;

UMLS CUI

C0033634;

Biochemical function of gene products
- Protein Kinase C Epsilon Type [NCIt concept]
- Protein Kinase C Iota Type [NCIt concept]
- Serine/Threonine-Protein Kinase N1 [NCIt concept]
Currated CISMeF NLP mapping
- protein kinase C [MeSH Descriptor]
- protein kinase C [MeSH concept]
False automatic mappings
- Protein kinase C (substance) [SNOMED CT concept]
- protein kinase C (15-28) [MeSH concept]
- protein kinase C (15-28) [MeSH Supplementary Concept]
- protein kinase C (19-31) [MeSH concept]
- protein kinase C (19-31) [MeSH Supplementary Concept]
- protein kinase C (19-36) [MeSH concept]
- protein kinase C (19-36) [MeSH Supplementary Concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- Protein kinase C (substance) [SNOMED CT concept]
- protein kinase C [MeSH Descriptor]
- protein kinase C [MeSH concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_product_affected_by_chemical_or_drug
- 7-Hydroxystaurosporine [NCIt concept]
- Bryostatin 1 [NCIt concept]
- Safingol [NCIt concept]
- Safingol Hydrochloride [NCIt concept]
gene_product_has_biochemical_function
- Serine/Threonine Protein Kinase [NCIt concept]
gene_product_is_biomarker_type
- Biomarker [NCIt concept]
gene_product_plays_role_in_biological_process
- Serine/Threonine Phosphorylation [NCIt concept]
- Signal Transduction [NCIt concept]
has_gene_product_element
- Protein Kinase C Alpha Type [NCIt concept]
- Protein Kinase C Beta Type [NCIt concept]
is_chemical_classification_of_gene_product
- Serine/Threonine-Protein Kinase D1 [NCIt concept]
- Serine/Threonine-Protein Kinase D2 [NCIt concept]
- Serine/Threonine-Protein Kinase D3 [NCIt concept]
is_target
- 7-Hydroxystaurosporine [NCIt concept]
- Bryostatin 1 [NCIt concept]
- Curcumin [NCIt concept]
- Darovasertib [NCIt concept]
- Enzastaurin [NCIt concept]
- Enzastaurin Hydrochloride [NCIt concept]
- Midostaurin [NCIt concept]
- Sotrastaurin Acetate [NCIt concept]
- Tigilanol Tiglate [NCIt concept]

Keyword's position in hierarchy(ies) :

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