Safingol - CISMeF

Preferred Label : Safingol;

NCIt synonyms : (2S,3S)-2-Amino-1,3-Octadecanediol; Sphinganine; L-(-)-threo-Sphingnine; L-threo-2-Amino-1,3-octadecanediol; Dihydrosphingosine;

NCIt related terms : L-threo-dihydrosphingosine;

NCIt definition : A saturated derivative of sphingosine. As an inhibitor of protein kinase C (PKC), safingol competitively binds to the regulatory phorbol-binding domain of PKC, a kinase involved in tumorigenesis. This agent has been shown to act synergistically with other chemotherapeutic agents and may potentiate chemotherapy drug-induced apoptosis in vitro and in vivo.;

Alternative definition : NCI-GLOSS: A substance that is being studied in the treatment of cancer. It belongs to the family of drugs called protein kinase inhibitors.;

UNII : OWA98U788S;

InChIKey : OTKJDMGTUTTYMP-ROUUACIJSA-N;

CAS number : 15639-50-6;

Drug name : Kynacyte;

Molecule name : SPC-100270;

Chemical formula : C18H39NO2;

NSC code : 714503;

Codes from synonyms : CDR0000386229; CDR0000513024; 20441; NSC0714503;

Details

Origin ID

C1568;

UMLS CUI

C0281466;

Automatic exact mappings (from CISMeF team)
- Dihydrosphingosine (substance) [SNOMED CT concept]
- dihydrosphingosine [SNOMED Notion]
- dihydrosphingosine [MeSH concept]
Currated CISMeF NLP mapping
- safingol [Substance BNPC]
- safingol [MeSH concept]
- safingol [MeSH Supplementary Concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- safingol [Substance BNPC]
- safingol [MeSH concept]
- safingol [MeSH Supplementary Concept]
chemical_or_drug_affects_gene_product
- Protein Kinase C [NCIt concept]
chemical_or_drug_has_mechanism_of_action
- Enzyme Inhibition [NCIt concept]
chemical_or_drug_has_physiologic_effect
- Positive Regulation of Apoptosis [NCIt concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_salt_form
- Safingol Hydrochloride [NCIt concept]
has_target
- Protein Kinase C Alpha Type [NCIt concept]
is_component_of_chemotherapy_regimen
- Cisplatin/Safingol [NCIt concept]
is_free_acid_or_base_form_of
- Safingol Hydrochloride [NCIt concept]

Keyword's position in hierarchy(ies) :

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