Safingol Hydrochloride

Preferred Label : Safingol Hydrochloride;

NCIt synonyms : Safingol HCl; (2S,3S)-2-Amino-1,3-Octadecanediol Hydrochloride; 1,3-Octadecanediol, 2-amino-, Hydrochloride, (S-(R*,R*))-;

NCIt definition : The hydrochloride salt of a saturated derivative of sphingosine. As an inhibitor of protein kinase C (PKC), safingol competitively binds to the regulatory phorbol-binding domain of PKC, a kinase involved in tumorigenesis. This agent has been shown to act synergistically with other chemotherapeutic agents and may potentiate chemotherapy drug-induced apoptosis in vitro and in vivo.;

UNII : 30MA50WJ4N;

InChIKey : BEHHCQFBLOARIX-APTPAJQOSA-N;

CAS number : 139755-79-6; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 139755-79-6 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Molecule name : SPC-100271;

Chemical formula : C18H39NO2.HCl;

Details

Origin ID

C80327;

UMLS CUI

C0888599;

Currated CISMeF NLP mapping
- safingol hydrochloride [MeSH concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- safingol hydrochloride [MeSH concept]
Validated automatic mappings to NTBT
- safingol [MeSH Supplementary Concept]
chemical_or_drug_affects_gene_product
- Protein Kinase C [NCIt concept]
chemical_or_drug_has_mechanism_of_action
- Enzyme Inhibition [NCIt concept]
chemical_or_drug_has_physiologic_effect
- Positive Regulation of Apoptosis [NCIt concept]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
has_free_acid_or_base_form
- Safingol [NCIt concept]
is_salt_form_of
- Safingol [NCIt concept]

Keyword's position in hierarchy(ies) :

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