protein kinase C

Preferred Label : protein kinase C;

MeSH definition : An serine-threonine protein kinase that requires the presence of physiological concentrations of CALCIUM and membrane PHOSPHOLIPIDS. The additional presence of DIACYLGLYCEROLS markedly increases its sensitivity to both calcium and phospholipids. The sensitivity of the enzyme can also be increased by PHORBOL ESTERS and it is believed that protein kinase C is the receptor protein of tumor-promoting phorbol esters.;

MeSH synonym : calcium-activated phospholipid-dependent kinase; calcium activated phospholipid dependent kinase; phospholipid-dependent kinase, calcium-activated; serine-threonine kinase, pkc; pkc serine-threonine kinase; calcium phospholipid dependent protein kinase; phospholipid sensitive calcium dependent protein kinase; pkc serine threonine kinase; calcium phospholipid-dependent protein kinase; phospholipid-sensitive calcium-dependent protein kinase;

MeSH hyponym : protein kinase M;

Registry Number MeSH : EC 2.7.11.13;

Is substance : O;

UNII : EC 2.7.11.13;

Details

Origin ID

D011493;

UMLS CUI

C0033634;

Allowable qualifiers
- administration and dosage [MeSH Qualifier]
- adverse effects [MeSH Qualifier]
- analysis [MeSH Qualifier]
- antagonists and inhibitors [MeSH Qualifier]
- biosynthesis [MeSH Qualifier]
- blood [MeSH Qualifier]
- cerebrospinal fluid [MeSH Qualifier]
- chemical synthesis [MeSH Qualifier]
- chemistry [MeSH Qualifier]
- classification [MeSH Qualifier]
- contraindications [MeSH Qualifier]
- deficiency [MeSH Qualifier]
- drug effects [MeSH Qualifier]
- economics [MeSH Qualifier]
- genetics [MeSH Qualifier]
- history [MeSH Qualifier]
- immunology [MeSH Qualifier]
- isolation and purification [MeSH Qualifier]
- metabolism [MeSH Qualifier]
- pharmacokinetics [MeSH Qualifier]
- pharmacology [MeSH Qualifier]
- physiology [MeSH Qualifier]
- poisoning [MeSH Qualifier]
- radiation effects [MeSH Qualifier]
- standards [MeSH Qualifier]
- supply and distribution [MeSH Qualifier]
- therapeutic use [MeSH Qualifier]
- toxicity [MeSH Qualifier]
- ultrastructure [MeSH Qualifier]
- urine [MeSH Qualifier]
Automatic exact mappings (from CISMeF team)
- Episodic kinesigenic dyskinesia 1 [OMIM Phenotype]
- PRRT2 wt Allele [NCIt concept]
- Protein kinase C (substance) [SNOMED CT concept]
- Serine/Threonine-Protein Kinase D1 [NCIt concept]
- Serine/Threonine-Protein Kinase D2 [NCIt concept]
- Serine/Threonine-Protein Kinase D3 [NCIt concept]
Currated CISMeF NLP mapping
- Protein Kinase C [NCIt concept]
Indexing information
- (4-(5-amino-4-carbamoylimidazol-1-yl)-2,3-dihydroxycyclopentyl) methyl phosphate [MeSH Supplementary Concept]
- 1,7-bis(3,4-dihydroxyphenyl)heptan-3-ol [MeSH Supplementary Concept]
- 1-(5-isoquinolinesulfonyl)piperazine [MeSH Supplementary Concept]
- 1-(5-isoquinolinylsulfonyl)-3-methylpiperazine [MeSH Supplementary Concept]
- 1-O-hexadecyl-2-O-methylglycerol [MeSH Supplementary Concept]
- 1-O-octadecyl-2-oleoyl-sn-glycero-3-phospho-(N-palmitoyl)ethanolamine [MeSH Supplementary Concept]
- 1-O-oleoyl-2-chloro-2-deoxy-3-phosphatidylcholine [MeSH Supplementary Concept]
- 1-O-oleoyl-3-chloro-3-deoxy-2-phosphatidylcholine [MeSH Supplementary Concept]
- 1-dehydromelengestrol acetate [MeSH Supplementary Concept]
- 1-hexylindolactam-V10 [MeSH Supplementary Concept]
- 10''-deoxybalanol [MeSH Supplementary Concept]
- 2,2',3,3',4,4'-hexahydroxy-1,1'-biphenyl-6,6'-dimethanol dimethyl ether [MeSH Supplementary Concept]
- 2-O-oleoyl-1-chloro-1-deoxy-3-phosphatidylcholine [MeSH Supplementary Concept]
- 2-hexadecylamino-2,3-bis(hydroxymethyl)norbornene [MeSH Supplementary Concept]
- 2-hexadecylamino-2-hydroxymethylnorbornene [MeSH Supplementary Concept]
- 4'-demethylamino-4',5'-dihydroxystaurosporine [MeSH Supplementary Concept]
- 4'-demethylamino-4'-hydroxy-3'-epistaurosporine [MeSH Supplementary Concept]
- 4'-demethylamino-4'-hydroxystaurosporine [MeSH Supplementary Concept]
- 4-propyl-5-(4-pyridinyl)-2(3H)-oxazolone [MeSH Supplementary Concept]
- 5,21 - 12,17-dimetheneo-18H-dibenzo(i,o)pyrrolo(3,4-1)(1,8)diazacyclohexandecine-18,10(19H)dione,8((dimethylamino)methyl)-6,7,8,9,10,11-hexahydro,monomethanesulfonate [MeSH Supplementary Concept]
- 5,7-dihydro-1,2,3,9,10,11-hexahydroxydibenz(c,e)oxepin [MeSH Supplementary Concept]
- 6-benzoyl-6-deacetylmayteine [MeSH Supplementary Concept]
- 6-deoxyisojacareubin [MeSH Supplementary Concept]
- 7-O-methyl-UCN 01 [MeSH Supplementary Concept]
- 7-hydroxystaurosporine [MeSH Supplementary Concept]
- 7-oxostaurosporine [MeSH Supplementary Concept]
- AM 44 [MeSH Supplementary Concept]
- BRS1 compound [MeSH Supplementary Concept]
- C1 peptide [MeSH Supplementary Concept]
- CGP 44800 [MeSH Supplementary Concept]
- CGP 53506 [MeSH Supplementary Concept]
- CRT0066854 [MeSH Supplementary Concept]
- HINT1 protein, human [MeSH Supplementary Concept]
- Hint1 protein, mouse [MeSH Supplementary Concept]
- ISIS 3521 [MeSH Supplementary Concept]
- KT 5720 [MeSH Supplementary Concept]
- KT 5822 [MeSH Supplementary Concept]
- LY 170198 [MeSH Supplementary Concept]
- MDL 29152 [MeSH Supplementary Concept]
- N,N,N-trimethyl-N'-cholesteryl amidoethyl ammonium [MeSH Supplementary Concept]
- N,N,N-trimethylsphingosine [MeSH Supplementary Concept]
- N,N-dimethylstaurosporine [MeSH Supplementary Concept]
- N-(2-aminoethyl)-5-isoquinolinesulfonamide [MeSH Supplementary Concept]
- N-ethoxycarbonyl-7-oxostaurosporine [MeSH Supplementary Concept]
- N-myristoyl-arginyl-lysyl-arginyl-threonyl-leucyl-arginyl-arginyl-leucine [MeSH Supplementary Concept]
- N-myristoyl-lysyl-arginyl-threonyl-leucyl-arginine [MeSH Supplementary Concept]
- NA 0345 [MeSH Supplementary Concept]
- NA 0346 [MeSH Supplementary Concept]
- NPC 15342 [MeSH Supplementary Concept]
- PKCz1257.3 compound [MeSH Supplementary Concept]
- POC 16 [MeSH Supplementary Concept]
- Pkc1 protein, trichoderma reesei [MeSH Supplementary Concept]
- R 8605 [MeSH Supplementary Concept]
- RK 286D [MeSH Supplementary Concept]
- SCH 47112 [MeSH Supplementary Concept]
- ZB14 protein, zea mays [MeSH Supplementary Concept]
- aprinocarsen [MeSH Supplementary Concept]
- azepinostatin [MeSH Supplementary Concept]
- balmoralmycin [MeSH Supplementary Concept]
- bisindolylmaleimide [MeSH Supplementary Concept]
- bisindolylmaleimide I [MeSH Supplementary Concept]
- bisindolylmaleimide II [MeSH Supplementary Concept]
- brain protein 87-kDa, bos taurus [MeSH Supplementary Concept]
- calphostin A [MeSH Supplementary Concept]
- calphostin B [MeSH Supplementary Concept]
- calphostin C [MeSH Supplementary Concept]
- calphostin D [MeSH Supplementary Concept]
- calphostin I [MeSH Supplementary Concept]
- calphostin complex [MeSH Supplementary Concept]
- cercosporin [MeSH Supplementary Concept]
- chelerythrine [MeSH Supplementary Concept]
- cholesterylphosphoryldimethylethanolamine [MeSH Supplementary Concept]
- compound 371196 [MeSH Supplementary Concept]
- corallidictyal A [MeSH Supplementary Concept]
- corosolic acid [MeSH Supplementary Concept]
- daphnetoxin [MeSH Supplementary Concept]
- davallin [MeSH Supplementary Concept]
- debromohymenialdisine [MeSH Supplementary Concept]
- dihydrolicoisoflavone [MeSH Supplementary Concept]
- doxorubicin-iron complex [MeSH Supplementary Concept]
- fim 1 [MeSH Supplementary Concept]
- fim 2 [MeSH Supplementary Concept]
- go 6976 [MeSH Supplementary Concept]
- goedecke 6976 [MeSH Supplementary Concept]
- hispidin [MeSH Supplementary Concept]
- hypericin [MeSH Supplementary Concept]
- isoaaptamine [MeSH Supplementary Concept]
- manzamenone A [MeSH Supplementary Concept]
- mayteine [MeSH Supplementary Concept]
- midostaurin [MeSH Supplementary Concept]
- ophiocordin [MeSH Supplementary Concept]
- peptide I [MeSH Supplementary Concept]
- phorbol 12-pyrenebutyrate 13-(3,3,3-trifloro-2-diazopropioate) [MeSH Supplementary Concept]
- plasmalopsychosine A [MeSH Supplementary Concept]
- plasmalopsychosine B [MeSH Supplementary Concept]
- prostate apoptosis response-4 protein [MeSH Supplementary Concept]
- protein kinase C (19-31) [MeSH Supplementary Concept]
- protein kinase C (19-36) [MeSH Supplementary Concept]
- protein kinase C-binding protein Beta15, rat [MeSH Supplementary Concept]
- pseudohypericin [MeSH Supplementary Concept]
- rim 1 [MeSH Supplementary Concept]
- ro 31-7549 [MeSH Supplementary Concept]
- ro 31-8220 [MeSH Supplementary Concept]
- ro 31-8425 [MeSH Supplementary Concept]
- ro 31-8830 [MeSH Supplementary Concept]
- ro 32-0432 [MeSH Supplementary Concept]
- ro 32-2241 [MeSH Supplementary Concept]
- ruboxistaurin [MeSH Supplementary Concept]
- safingol [MeSH Supplementary Concept]
- staurosporine aglycone [MeSH Supplementary Concept]
- tiflucarbine [MeSH Supplementary Concept]
- vanicoside A [MeSH Supplementary Concept]
- vanicoside B [MeSH Supplementary Concept]
Record concept(s)
- protein kinase C [MeSH concept]
- protein kinase M [MeSH concept]
Related MeSH Supplementary Concept(s)
- DKF-2 protein, C elegans [MeSH Supplementary Concept]
- InaC protein, drosophila [MeSH Supplementary Concept]
- PKC-1 protein, C elegans [MeSH Supplementary Concept]
- PKC-2 protein, C elegans [MeSH Supplementary Concept]
- PKC-3 protein [MeSH Supplementary Concept]
- PKC1 protein, S cerevisiae [MeSH Supplementary Concept]
- PKCA protein, aspergillus niger [MeSH Supplementary Concept]
- PRKCH protein, human [MeSH Supplementary Concept]
- PRKCQ protein, human [MeSH Supplementary Concept]
- Par-6 protein, drosophila [MeSH Supplementary Concept]
- Pck1 protein, S pombe [MeSH Supplementary Concept]
- Pkc1 protein, trichoderma reesei [MeSH Supplementary Concept]
- Pkc98E protein, Drosophila [MeSH Supplementary Concept]
- Prkch protein, rat [MeSH Supplementary Concept]
- Prkcq protein, rat [MeSH Supplementary Concept]
- aPKC protein, Drosophila [MeSH Supplementary Concept]
- apl II protein kinase C [MeSH Supplementary Concept]
- calcium-independent protein kinase C [MeSH Supplementary Concept]
- nPKC p105, mussel [MeSH Supplementary Concept]
- phorbol ester receptor [MeSH Supplementary Concept]
- prkcq protein, mouse [MeSH Supplementary Concept]
- protein kinase C (15-28) [MeSH Supplementary Concept]
- protein kinase C (19-31) [MeSH Supplementary Concept]
- protein kinase C (19-36) [MeSH Supplementary Concept]
- protein kinase C eta [MeSH Supplementary Concept]
- protein kinase C gamma [MeSH Supplementary Concept]
- protein kinase C gamma (101-112) [MeSH Supplementary Concept]
- protein kinase C gamma (141-151) [MeSH Supplementary Concept]
- protein kinase C lambda [MeSH Supplementary Concept]
- protein kinase C nu [MeSH Supplementary Concept]
- protein kinase C zeta [MeSH Supplementary Concept]
- protein kinase C zeta II, mouse [MeSH Supplementary Concept]
- protein kinase D [MeSH Supplementary Concept]
- protein kinase M zeta, rat [MeSH Supplementary Concept]
- protein kinase N [MeSH Supplementary Concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- Protein Kinase C [NCIt concept]
- Protein kinase C (substance) [SNOMED CT concept]

Keyword's position in hierarchy(ies) :

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