Midostaurin - CISMeF

Preferred Label : Midostaurin;

NCIt synonyms : N-Benzoylstaurosporine;

NCIt related terms : PKC412; CGP 41251; N-benzoyl-staurosporine;

NCIt definition : A synthetic indolocarbazole multikinase inhibitor with potential antiangiogenic and antineoplastic activities. Midostaurin inhibits protein kinase C alpha (PKCalpha), vascular endothelial growth factor receptor 2 (VEGFR2), c-kit, platelet-derived growth factor receptor (PDGFR) and FMS-like tyrosine kinase 3 (FLT3) tyrosine kinases, which may result in disruption of the cell cycle, inhibition of proliferation, apoptosis, and inhibition of angiogenesis in susceptible tumors.;

Alternative definition : NCI-GLOSS: A substance that is being studied in the treatment of leukemia. It belongs to the family of drugs called protein kinase inhibitors.;

UNII : ID912S5VON;

InChIKey : BMGQWWVMWDBQGC-IIFHNQTCSA-N;

CAS number : 120685-11-2; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 120685-11-2 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Drug name : Rydapt;

Molecule name : PKC-412; CGP41251;

Chemical formula : C35H30N4O4;

ChEBI ID : CHEBI:63452;

Codes from synonyms : CDR0000513012; 31646; CDR0000513009; CDR0000269425; 333;

Details

Origin ID

C1872;

UMLS CUI

C0526371;

Automatic exact mappings (from CISMeF team)
- CGP 41251 [MeSH concept]
- Midostaurin [ICD-11 Extension code]
- midostaurin [ATC Code]
See also inter- (CISMeF)
- Product containing midostaurin (medicinal product) [SNOMED CT concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
concept_is_in_subset
- AML Authorized Value Terminology [NCIt concept]
- AML Total Dose Table [NCIt concept]
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- HemOnc Agent Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- Mast/Stem Cell Growth Factor Receptor Kit [NCIt concept]
- Platelet-Derived Growth Factor Receptor [NCIt concept]
- Protein Kinase C [NCIt concept]
- Receptor-Type Tyrosine-Protein Kinase FLT3 [NCIt concept]
- Vascular Endothelial Growth Factor Receptor 2 [NCIt concept]
is_component_of_chemotherapy_regimen
- Cytarabine/Daunorubicin/Midostaurin Regimen [NCIt concept]
- Cytarabine/Midostaurin Regimen [NCIt concept]
- Midostaurin Regimen [NCIt concept]

Keyword's position in hierarchy(ies) :

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