NCIt related terms : PKC412; CGP 41251; N-benzoyl-staurosporine;
NCIt definition : A synthetic indolocarbazole multikinase inhibitor with potential antiangiogenic and
antineoplastic activities. Midostaurin inhibits protein kinase C alpha (PKCalpha),
vascular endothelial growth factor receptor 2 (VEGFR2), c-kit, platelet-derived growth
factor receptor (PDGFR) and FMS-like tyrosine kinase 3 (FLT3) tyrosine kinases, which
may result in disruption of the cell cycle, inhibition of proliferation, apoptosis,
and inhibition of angiogenesis in susceptible tumors.;
Alternative definition : NCI-GLOSS: A substance that is being studied in the treatment of leukemia. It belongs
to the family of drugs called protein kinase inhibitors.;
UNII : ID912S5VON;
InChIKey : BMGQWWVMWDBQGC-IIFHNQTCSA-N;
CAS number : 120685-11-2;
Drug name : Rydapt;
Molecule name : PKC-412; CGP41251; PKC 412;
Chemical formula : C35H30N4O4;
ChEBI ID : CHEBI:63452;
Codes from synonyms : CDR0000513012; 31646; CDR0000513009; CDR0000269425; 333;