" /> Midostaurin - CISMeF





Preferred Label : Midostaurin;

NCIt synonyms : N-Benzoylstaurosporine;

NCIt related terms : PKC412; CGP 41251; N-benzoyl-staurosporine;

NCIt definition : A synthetic indolocarbazole multikinase inhibitor with potential antiangiogenic and antineoplastic activities. Midostaurin inhibits protein kinase C alpha (PKCalpha), vascular endothelial growth factor receptor 2 (VEGFR2), c-kit, platelet-derived growth factor receptor (PDGFR) and FMS-like tyrosine kinase 3 (FLT3) tyrosine kinases, which may result in disruption of the cell cycle, inhibition of proliferation, apoptosis, and inhibition of angiogenesis in susceptible tumors.;

Alternative definition : NCI-GLOSS: A substance that is being studied in the treatment of leukemia. It belongs to the family of drugs called protein kinase inhibitors.;

UNII : ID912S5VON;

InChIKey : BMGQWWVMWDBQGC-IIFHNQTCSA-N;

CAS number : 120685-11-2;

Drug name : Rydapt;

Molecule name : PKC-412; CGP41251; PKC 412;

Chemical formula : C35H30N4O4;

ChEBI ID : CHEBI:63452;

Codes from synonyms : CDR0000513012; 31646; CDR0000513009; CDR0000269425; 333;

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30/05/2025


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