Preferred Label : 7-Hydroxystaurosporine;
NCIt synonyms : 7-Hydroxy-staurosporine; 8,12-Epoxy-1H,8H-2,7b,12a-triazadibenzo[a, g]cyclonona[cde] Trinden-1-one, 2,3,9,10,11,
12-hexahydro-3-hydroxy-9-methoxy-8-methyl-10-(methylamino); 7-Hydroxystaurosporine;
NCIt related terms : UCN-01; ( )-UCN-01; 2,3,9,10,11,12-Hexahydro-3-hydroxy-9-methoxy-8-methyl-10-(methylamino)-8,12-epoxy-1H,8H-2,7b,12a-triazadibenzo(a,g)cyclonona(cde)triinden-1-one;
NCIt definition : A synthetic derivative of staurosporine with antineoplastic activity. 7-hydroxystaurosporine
inhibits many phosphokinases, including the serine/threonine kinase AKT, calcium-dependent
protein kinase C, and cyclin-dependent kinases. This agent arrests tumor cells in
the G1/S of the cell cycle and prevents nucleotide excision repair by inhibiting the
G2 checkpoint kinase chk1, resulting in apoptosis. (NCI04);
Alternative definition : NCI-GLOSS: An anticancer drug that belongs to the family of drugs called staurosporine
analogues.;
UNII : 7BU5H4V94A;
InChIKey : PBCZSGKMGDDXIJ-HQCWYSJUSA-N;
CAS number : 112953-11-4;
Molecule name : UCN-01;
Chemical formula : C28H26N4O4;
NSC code : 638850;
Codes from synonyms : NSC0638850; 30071; CDR0000045447;
Origin ID : C1271;
UMLS CUI : C0077681;
Currated CISMeF NLP mapping
- See also inter- (CISMeF)
- Semantic type(s)
- UMLS correspondences (same concept)
- chemical_or_drug_affects_gene_product
- chemical_or_drug_has_mechanism_of_action
- chemical_or_drug_has_physiologic_effect
- concept_is_in_subset
- has_target
- is_component_of_chemotherapy_regimen
