Preferred Label : Protein Kinase B;
NCIt related terms : Akt;
NCIt definition : Expressed in diverse tissues, Protein Kinase B (AKT/RAC Family) is a group (Alpha,
Beta and Gamma) of cytoplasmic serine/threonine enzymes that covalently transfer the
terminal, gamma phosphate group from ATP to a variety of substrate proteins and regulate
cell signaling responses to insulin, PDGF, and IGF1 (through PI3K) involved in cell
survival, cell proliferation, differentiation, apoptosis, glycogen synthesis, and
glucose uptake.;
Alternative definition : NCI-GLOSS: A group of enzymes involved in several processes related to cell growth
and survival. Protein kinase B enzymes help to transfer signals inside cells. A protein
kinase B enzyme is a type of serine/threonine protein kinase.;
Codes from synonyms : CDR0000653105; CDR0000653106;
Origin ID : C41625;
UMLS CUI : C0164786;
Currated CISMeF NLP mapping
- Semantic type(s)
- UMLS correspondences (same concept)
- concept_is_in_subset
- gene_product_affected_by_chemical_or_drug
- gene_product_has_biochemical_function
- gene_product_plays_role_in_biological_process
- has_gene_product_element
- is_target
