Synthetic Plumbagin PCUR-101

Preferred Label : Synthetic Plumbagin PCUR-101;

NCIt related terms : PLUMBAGIN;

NCIt definition : A synthetic form of the plant-derived medicinal agent, plumbagin, with potential antineoplastic activity. Plumbagin may act by inhibiting the expression of protein kinase C epsilon (PKCe), signal transducers and activators of transcription 3 phosphorylation (Stat3), protein kinase B (AKT), and certain epithelial-to-mesenchymal transition (EMT) markers, including vimentin and slug. This results in possible inhibition of proliferation in susceptible tumor cells. PKCe, Stat3, AKT, and the EMT markers vimentin and slug have been linked to the induction and progression of prostate cancer.;

UNII : YAS4TBQ4OQ;

CAS number : 481-42-5; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 481-42-5 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Molecule name : PCUR-101; PCUR 101;

NCI Metathesaurus CUI : CL971629;

Details

Origin ID

C166377;

UMLS CUI

C4733572;

Semantic type(s)
- Pharmacologic Substance [UMLS semantic type]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- Protein Kinase B [NCIt concept]
- Protein Kinase C Epsilon Type [NCIt concept]
- Signal Transducer and Activator of Transcription 3 [NCIt concept]
- Vimentin [NCIt concept]
- Zinc Finger Protein SNAI2 [NCIt concept]

Keyword's position in hierarchy(ies) :

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