Preferred Label : Vevorisertib;
NCIt synonyms : AKT Inhibitor ARQ751; Pan-AKT Inhibitor ARQ751;
NCIt definition : An orally bioavailable pan inhibitor of the serine/threonine protein kinase AKT (protein
kinase B) enzyme family with potential antineoplastic activity. Upon oral administration,
vevorisertib selectively binds to and inhibits the activity of the AKT isoforms 1,
2 and 3, which may result in the inhibition of the phosphatidylinositol 3-kinase (PI3K)/AKT
signaling pathway. This may lead to a reduction in tumor cell proliferation and the
induction of tumor cell apoptosis. The AKT signaling pathway is often deregulated
in cancer and is associated with tumor cell proliferation, survival and migration.;
UNII : V6SX910Y31;
InChIKey : NZDSLYATTDIDPH-UHFFFAOYSA-N;
CAS number : 1416775-46-6;
Molecule name : MK-4440; ARQ 751; ARQ-751; MK 4440;
NCI Metathesaurus CUI : CL1413089;
Origin ID : C175873;
UMLS CUI : C5448042;
Semantic type(s)
- concept_is_in_subset
- has_target
