Preferred Label : Uprosertib;
NCIt synonyms : Oral Akt Inhibitor GSK2141795; 2-Furancarboxamide, N-((1S)-2-Amino-1-((3,4-difluorophenyl)methyl)ethyl)-5-chloro-4-(4-chloro-1-methyl-1H-pyrazol-5-yl)-;
NCIt definition : An orally bioavailable inhibitor of the serine/threonine protein kinase Akt (protein
kinase B) with potential antineoplastic activity. Uprosertib binds to and inhibits
the activity of Akt, which may result in inhibition of the PI3K/Akt signaling pathway
and tumor cell proliferation and the induction of tumor cell apoptosis. Activation
of the PI3K/Akt signaling pathway is frequently associated with tumorigenesis and
dysregulated PI3K/Akt signaling may contribute to tumor resistance to a variety of
antineoplastic agents.;
UNII : ZXM835LQ5E;
InChIKey : AXTAPYRUEKNRBA-JTQLQIEISA-N;
CAS number : 1047634-65-0; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 1047634-65-0
alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo
G-SRS /a ;
Molecule name : GSK2141795;
Origin ID : C84870;
UMLS CUI : C4519272;
Semantic type(s)
- concept_is_in_subset
- has_target
