" /> Afuresertib - CISMeF





Preferred Label : Afuresertib;

NCIt synonyms : 2-Thiophenecarboxamide, N-((1S)-2-amino-1-((3-fluorophenyl)methyl)ethyl)-5-chloro-4-(4-chloro-1-methyl-1H-pyrazol-5-yl)-; Oral Akt Inhibitor GSK2110183;

NCIt definition : An orally bioavailable inhibitor of the serine/threonine protein kinase Akt (protein kinase B) with potential antineoplastic activity. Afuresertib binds to and inhibits the activity of Akt, which may result in inhibition of the PI3K/Akt signaling pathway and tumor cell proliferation and the induction of tumor cell apoptosis. Activation of the PI3K/Akt signaling pathway is frequently associated with tumorigenesis and dysregulated PI3K/Akt signaling may contribute to tumor resistance to a variety of antineoplastic agents.;

UNII : 8739X25QI3;

InChIKey : AFJRDFWMXUECEW-LBPRGKRZSA-N;

CAS number : 1047644-62-1; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 1047644-62-1 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Molecule name : GSK2110183;

Codes from synonyms : 14;

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Keyword's position in hierarchy(ies) : arborescence

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12/05/2024


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