NCIt definition : The hydrochloride salt form of afuresertib, an orally bioavailable inhibitor of the
serine/threonine protein kinase Akt (protein kinase B), with potential antineoplastic
activity. Upon oral administration, afuresertib binds to and inhibits the activity
of Akt, which may result in inhibition of the PI3K/Akt signaling pathway and tumor
cell proliferation and the induction of tumor cell apoptosis. Activation of the PI3K/Akt
signaling pathway is frequently associated with tumorigenesis and dysregulated PI3K/Akt
signaling may contribute to tumor resistance to a variety of antineoplastic agents.;
Semantic type(s)