" /> Akt Inhibitor MK2206 - CISMeF





Preferred Label : Akt Inhibitor MK2206;

NCIt synonyms : 1,2,4-Triazolo(3,4-f)(1,6)naphthyridin-3(2H)-one, 8-(4-(1-aminocyclobutyl)phenyl)-9-phenyl-;

NCIt related terms : MK-2206 FREE BASE; MK2206;

NCIt definition : An orally bioavailable allosteric inhibitor of the serine/threonine protein kinase Akt (protein kinase B) with potential antineoplastic activity. Akt inhibitor MK2206 binds to and inhibits the activity of Akt in a non-ATP competitive manner, which may result in the inhibition of the PI3K/Akt signaling pathway and tumor cell proliferation and the induction of tumor cell apoptosis. Activation of the PI3K/Akt signaling pathway is frequently associated with tumorigenesis and dysregulated PI3K/Akt signaling may contribute to tumor resistance to a variety of antineoplastic agents.;

Alternative definition : NCI-GLOSS: An orally bioavailable allosteric inhibitor of the serine/threonine protein kinase Akt (protein kinase B) with potential antineoplastic activity. Akt inhibitor MK2206 binds to and inhibits the activity of Akt in a non-ATP competitive manner, which may result in the inhibition of the PI3K/Akt signaling pathway and tumor cell proliferation and the induction of tumor cell apoptosis. Activation of the PI3K/Akt signaling pathway is frequently associated with tumorigenesis and dysregulated PI3K/Akt signaling may contribute to tumor resistance to a variety of antineoplastic agents;

UNII : 51HZG6MP1K;

InChIKey : ULDXWLCXEDXJGE-UHFFFAOYSA-N;

CAS number : 1032349-93-1;

Molecule name : MK-2206; MK 2206;

Codes from synonyms : CDR000596332;

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Keyword's position in hierarchy(ies) : arborescence

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08/05/2025


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