NCIt definition : An orally bioavailable allosteric inhibitor of the serine/threonine protein kinase
Akt (protein kinase B) with potential antineoplastic activity. Akt inhibitor MK2206
binds to and inhibits the activity of Akt in a non-ATP competitive manner, which may
result in the inhibition of the PI3K/Akt signaling pathway and tumor cell proliferation
and the induction of tumor cell apoptosis. Activation of the PI3K/Akt signaling pathway
is frequently associated with tumorigenesis and dysregulated PI3K/Akt signaling may
contribute to tumor resistance to a variety of antineoplastic agents.;
Alternative definition : NCI-GLOSS: An orally bioavailable allosteric inhibitor of the serine/threonine protein
kinase Akt (protein kinase B) with potential antineoplastic activity. Akt inhibitor
MK2206 binds to and inhibits the activity of Akt in a non-ATP competitive manner,
which may result in the inhibition of the PI3K/Akt signaling pathway and tumor cell
proliferation and the induction of tumor cell apoptosis. Activation of the PI3K/Akt
signaling pathway is frequently associated with tumorigenesis and dysregulated PI3K/Akt
signaling may contribute to tumor resistance to a variety of antineoplastic agents;
UNII : 51HZG6MP1K;
InChIKey : ULDXWLCXEDXJGE-UHFFFAOYSA-N;
CAS number : 1032349-93-1; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 1032349-93-1
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