Capivasertib - CISMeF

Preferred Label : Capivasertib;

NCIt definition : A novel pyrrolopyrimidine derivative, and an orally available inhibitor of the serine/threonine protein kinase AKT (protein kinase B) with potential antineoplastic activity. Capivasertib binds to and inhibits all AKT isoforms. Inhibition of AKT prevents the phosphorylation of AKT substrates that mediate cellular processes, such as cell division, apoptosis, and glucose and fatty acid metabolism. A wide range of solid and hematological malignancies show dysregulated PI3K/AKT/mTOR signaling due to mutations in multiple signaling components. By targeting AKT, the key node in the PIK3/AKT signaling network, this agent may be used as monotherapy or combination therapy for a variety of human cancers.;

UNII : WFR23M21IE;

InChIKey : JDUBGYFRJFOXQC-KRWDZBQOSA-N;

CAS number : 1143532-39-1;

Drug name : Truqap;

Molecule name : AZD 5363; AZD-5363;

Codes from synonyms : 2;

Details

Origin ID

C102564;

UMLS CUI

C4682387;

Currated CISMeF NLP mapping
- Capivasertib [SMS substance]
- capivasertib [MeSH Supplementary Concept]
- capivasertib [MeSH concept]
See also inter- (CISMeF)
- AZD5363 [MeSH concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- capivasertib [MeSH Supplementary Concept]
- capivasertib [ATC Code]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- HemOnc Agent Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- Protein Kinase B [NCIt concept]
is_component_of_chemotherapy_regimen
- Capivasertib/Fulvestrant Regimen [NCIt concept]

Keyword's position in hierarchy(ies) :

Main resources

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