NCIt definition : The ditosylate salt of lapatinib, a synthetic, orally-active quinazoline with potential
antineoplastic activity. Lapatinib reversibly blocks phosphorylation of the epidermal
growth factor receptor (EGFR), ErbB2, and the Erk-1 and-2 and AKT kinases; it also
inhibits cyclin D protein levels in human tumor cell lines and xenografts. EGFR and
ErbB2 have been implicated in the growth of various tumor types.;
Alternative definition : NCI-GLOSS: A drug used with another anticancer drug to treat breast cancer that is
HER2 positive and has advanced or metastasized (spread to other parts of the body)
after treatment with other drugs. Lapatinib ditosylate is also being studied in the
treatment of other types of cancer. It is a type of ErbB-2 and EGFR dual tyrosine
kinase inhibitor.;
UNII : G873GX646R;
InChIKey : XNRVGTHNYCNCFF-UHFFFAOYSA-N;
CAS number : 388082-78-8; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 388082-78-8
alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo
G-SRS /a ;
Drug name : Tykerb;
Chemical formula : C29H26ClFN4O4S.2C7H8O3S.H2O;
Codes from synonyms : 50669; CDR0000489115; CDR0000539453;