Receptor Tyrosine-Protein Kinase erbB-2

Preferred Label : Receptor Tyrosine-Protein Kinase erbB-2;

NCIt synonyms : ERBB2; c-erbB-2; HER-2; HER2; NEU; Antigen CD340; Tyrosine Kinase-Type Cell Surface Receptor HER2; p185erbB2; ERBB2 Receptor Protein-Tyrosine Kinase; CD340 Antigen; Metastatic Lymph Node Gene 19 Protein; EC 2.7.10.1; MLN 19; Proto-Oncogene Neu; CD340; Proto-Oncogene c-ErbB-2;

NCIt related terms : human epidermal growth factor receptor 2; human EGF receptor 2; HER2/neu;

NCIt definition : Receptor tyrosine-protein kinase erbB-2 (1255 aa, 138 kDa) is encoded by the human ERBB2 gene. This protein is involved in cell proliferation, tyrosine phosphorylation and signal transduction.;

Alternative definition : NCI-GLOSS: A protein involved in normal cell growth. It is found on some types of cancer cells, including breast and ovarian. Cancer cells removed from the body may be tested for the presence of c-erbB-2 to help decide the best type of treatment. c-erbB-2 is a type of receptor tyrosine kinase.;

NCIt note : Receptor tyrosine-protein kinase erbB-2 is a ligandless receptor and only has activity after dimerization with other ErbB receptors.;

Codes from synonyms : CDR0000044945; CDR0000045631; CDR0000633223; CDR0000044570;

Details

Origin ID

C17319;

UMLS CUI

C1702024;

Automatic exact mappings (from CISMeF team)
- ERBB2 protein, human [MeSH Supplementary Concept]
- Erb-b2 receptor tyrosine kinase 2 [OMIM gene]
- HER2 [LOINC component]
- HER2(776-788) [MeSH concept]
- HER2(776-788) [MeSH Supplementary Concept]
- epidermal growth factor receptor 2, human [MeSH concept]
- erb-b2 receptor tyrosine kinase 2 [HGNC gene]
- erb-b2 receptor tyrosine kinase 2 [ORDO Gene]
- genes, erbB-2 [MeSH Descriptor]
- genes, erbB-2 [MeSH concept]
- her-2/neu [EMDN type]
- neuraminidase 1 [ORDO Gene]
- receptor, erbB-2 [MeSH Descriptor]
OMIM relation
- Erb-b2 receptor tyrosine kinase 2 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
- Receptor [UMLS semantic type]
UMLS correspondences (same concept)
- ERBB2 protein, human [MeSH concept]
- ERBB2 protein, human [MeSH Supplementary Concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- ERBB2 Gene [NCIt concept]
- Enzyme Gene [NCIt concept]
- Kinase Family Gene [NCIt concept]
- Ligand Binding Protein Gene [NCIt concept]
- Phosphotransferase Gene [NCIt concept]
- Receptor Gene [NCIt concept]
- Receptor Tyrosine Kinase Gene [NCIt concept]
- Transferase Gene [NCIt concept]
gene_product_affected_by_chemical_or_drug
- Afatinib [NCIt concept]
- Afatinib Dimaleate [NCIt concept]
- Allitinib [NCIt concept]
- Bispecific Antibody 2B1 [NCIt concept]
- Bispecific Monoclonal Antibody ASP2074 [NCIt concept]
- ERB-38 Immunotoxin [NCIt concept]
- Trastuzumab [NCIt concept]
gene_product_has_abnormality
- ERBB2 Protein Overexpression [NCIt concept]
gene_product_has_associated_anatomy
- Plasma Membrane [NCIt concept]
gene_product_has_biochemical_function
- Cell Surface Receptor [NCIt concept]
- Kinase [NCIt concept]
gene_product_has_chemical_classification
- Transmembrane Protein [NCIt concept]
gene_product_has_gene_product_variant
- ERBB2 NP_004439.2:p.C805S [NCIt concept]
- ERBB2 NP_004439.2:p.D769H [NCIt concept]
- ERBB2 NP_004439.2:p.D769N [NCIt concept]
- ERBB2 NP_004439.2:p.D769Y [NCIt concept]
- ERBB2 NP_004439.2:p.E321G [NCIt concept]
- ERBB2 NP_004439.2:p.E693K [NCIt concept]
- ERBB2 NP_004439.2:p.G309A [NCIt concept]
- ERBB2 NP_004439.2:p.G309E [NCIt concept]
- ERBB2 NP_004439.2:p.G660D [NCIt concept]
- ERBB2 NP_004439.2:p.G776C [NCIt concept]
- ERBB2 NP_004439.2:p.G776V [NCIt concept]
- ERBB2 NP_004439.2:p.G776delinsVC [NCIt concept]
- ERBB2 NP_004439.2:p.G778_P780dup [NCIt concept]
- ERBB2 NP_004439.2:p.H878Y [NCIt concept]
- ERBB2 NP_004439.2:p.I655V [NCIt concept]
- ERBB2 NP_004439.2:p.I767M [NCIt concept]
- ERBB2 NP_004439.2:p.L755P [NCIt concept]
- ERBB2 NP_004439.2:p.L755S [NCIt concept]
- ERBB2 NP_004439.2:p.L755X [NCIt concept]
- ERBB2 NP_004439.2:p.L755_T759del [NCIt concept]
- ERBB2 NP_004439.2:p.L786V [NCIt concept]
- ERBB2 NP_004439.2:p.L841V [NCIt concept]
- ERBB2 NP_004439.2:p.L866M [NCIt concept]
- ERBB2 NP_004439.2:p.L869R [NCIt concept]
- ERBB2 NP_004439.2:p.Q709L [NCIt concept]
- ERBB2 NP_004439.2:p.R678Q [NCIt concept]
- ERBB2 NP_004439.2:p.R896C [NCIt concept]
- ERBB2 NP_004439.2:p.S310F [NCIt concept]
- ERBB2 NP_004439.2:p.S310Y [NCIt concept]
- ERBB2 NP_004439.2:p.S653C [NCIt concept]
- ERBB2 NP_004439.2:p.T733I [NCIt concept]
- ERBB2 NP_004439.2:p.T862A [NCIt concept]
- ERBB2 NP_004439.2:p.T862I [NCIt concept]
- ERBB2 NP_004439.2:p.V659E [NCIt concept]
- ERBB2 NP_004439.2:p.V697L [NCIt concept]
- ERBB2 NP_004439.2:p.V773M [NCIt concept]
- ERBB2 NP_004439.2:p.V777L [NCIt concept]
- ERBB2 NP_004439.2:p.V777M [NCIt concept]
- ERBB2 NP_004439.2:p.V842I [NCIt concept]
- ERBB2 NP_004439.2:p.Y772_A775dup [NCIt concept]
- ERBB2 Protein Variant [NCIt concept]
gene_product_has_structural_domain_or_motif
- Cytoplasmic Domain [NCIt concept]
- Extracellular Domain [NCIt concept]
- Ligand Binding Domain [NCIt concept]
- Substrate Interaction Domain [NCIt concept]
- Transmembrane Domain [NCIt concept]
- Tyrosine Kinase Domain [NCIt concept]
gene_product_is_biomarker_type
- Tumor Marker [NCIt concept]
gene_product_is_element_in_pathway
- Adherens Junction Assembly Pathway [NCIt concept]
- Alpha6/Beta1 and Alpha6/Beta4 Integrin Signaling Pathway [NCIt concept]
- Bladder Cancer Pathway [NCIt concept]
- Calcium-Mediated Signaling Pathway [NCIt concept]
- ERBB Family Signaling Pathway [NCIt concept]
- ERBB2 Signaling Pathway [NCIt concept]
- ERBB2/ERBB3 Signaling Pathway [NCIt concept]
- ERBB4 Signaling Pathway [NCIt concept]
- Endometrial Cancer Pathway [NCIt concept]
- Epidermal Growth Factor Receptor Family Pathway [NCIt concept]
- Focal Adhesion Pathway [NCIt concept]
- Mucosal Healing Pathway [NCIt concept]
- Non-Small Cell Lung Cancer Pathway [NCIt concept]
- Pancreatic Cancer Pathway [NCIt concept]
- Prostate Cancer Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Cell Differentiation Process [NCIt concept]
- Cell Growth [NCIt concept]
- Cell Growth Regulation [NCIt concept]
- Cell Proliferation [NCIt concept]
- Ligand Binding [NCIt concept]
- Phosphorylation Process [NCIt concept]
- Protein Phosphorylation Process [NCIt concept]
- Receptor Signaling [NCIt concept]
- Signal Transduction [NCIt concept]
- Tyrosine Phosphorylation [NCIt concept]
is_target
- AE37 Peptide/GM-CSF Vaccine [NCIt concept]
- Adenovirus HER2-Transduced Autologous Dendritic Cell Vaccine [NCIt concept]
- Afatinib [NCIt concept]
- Afatinib Dimaleate [NCIt concept]
- Allitinib [NCIt concept]
- Anbenitamab [NCIt concept]
- Anti-CD47/Anti-HER2 Bispecific Antibody IMM2902 [NCIt concept]
- Anti-EGFR/HER2/HER3 Monoclonal Antibody Mixture Sym013 [NCIt concept]
- Anti-ErbB2/Anti-ErbB3 Bispecific Monoclonal Antibody MM-111 [NCIt concept]
- Anti-HER2 ADC BB-1701 [NCIt concept]
- Anti-HER2 Antibody Conjugated Natural Killer Cells ACE1702 [NCIt concept]
- Anti-HER2 Antibody-drug Conjugate BAT8010 [NCIt concept]
- Anti-HER2 Antibody-drug Conjugate BL-M07D1 [NCIt concept]
- Anti-HER2 Antibody-drug Conjugate DB-1303 [NCIt concept]
- Anti-HER2 Antibody-drug Conjugate IBI354 [NCIt concept]
- Anti-HER2 Antibody-drug Conjugate MEDI4276 [NCIt concept]
- Anti-HER2 Bispecific Antibody KM257 [NCIt concept]
- Anti-HER2 Bispecific Antibody TQB2930 [NCIt concept]
- Anti-HER2 Bispecific Antibody-drug Conjugate ZW49 [NCIt concept]
- Anti-HER2 Dendritic Cell Vaccine [NCIt concept]
- Anti-HER2 GSPT1 Degrader ORM-5029 [NCIt concept]
- Anti-HER2 Immune Stimulator-antibody Conjugate NJH395 [NCIt concept]
- Anti-HER2 Molecule AIP-303 [NCIt concept]
- Anti-HER2 Monoclonal Antibody BAT1006 [NCIt concept]
- Anti-HER2 Monoclonal Antibody BAY2701438 [NCIt concept]
- Anti-HER2 Monoclonal Antibody QL1209 [NCIt concept]
- Anti-HER2-CAR Autologous CMV-Specific Cytotoxic T-Lymphocytes [NCIt concept]
- Anti-HER2-DM1 Antibody-drug Conjugate GQ1001 [NCIt concept]
- Anti-HER2-STING Agonist ADC XMT-2056 [NCIt concept]
- Anti-HER2-vc0101 ADC PF-06804103 [NCIt concept]
- Anti-HER2/4-1BB Bispecific Antibody YH32367 [NCIt concept]
- Anti-HER2/Anti-CD3 Bispecific Antibody M802 [NCIt concept]
- Anti-HER2/Anti-CD3 Bispecific Monoclonal Antibody GBR 1302 [NCIt concept]
- Anti-HER2/Anti-PD-1 Bispecific Antibody SSGJ-705 [NCIt concept]
- Anti-HER2/Auristatin Payload Antibody-drug Conjugate XMT-1522 [NCIt concept]
- Anti-HER2/CD3/CD28 Tri-specific Antibody SAR443216 [NCIt concept]
- Anti-HER2/CD3/XTEN Protease-activated T-cell Engager AMX-818 [NCIt concept]
- Anti-HER2/HER2 Bispecific ADC KM501 [NCIt concept]
- Anti-HER2/HER3 Dendritic Cell Vaccine [NCIt concept]
- Anti-HER2/PBD-MA Antibody-drug Conjugate DHES0815A [NCIt concept]
- Anti-HER2/Topoisomerase I Inhibitor ADC TQB2102 [NCIt concept]
- Anvatabart Opadotin [NCIt concept]
- Autologous Anti-HER2 CAR Macrophages CT-0508 [NCIt concept]
- Autologous Anti-HER2 CAR T-cells CCT303-406 [NCIt concept]
- Autologous Anti-HER2 CAR-CD28 T Cells [NCIt concept]
- Autologous Anti-HER2 CAR-T Cells [NCIt concept]
- Autologous B7-H3/EGFR806/HER2/IL13-zetakine CAR-expressing CD4+/CD8+ T-cells SC-CAR4BRAIN [NCIt concept]
- Autologous HER2-CAR-modified Adenovirus-specific Cytotoxic T-lymphocytes [NCIt concept]
- Autologous HER2-targeted Dual-switch CAR-T Cells BPX-603 [NCIt concept]
- Autologous IL-15-expanded HER2-specific CD4+ T-cells [NCIt concept]
- Autologous IL-7-expanded HER2-specific CD4+ T-cells [NCIt concept]
- Autologous TGFbeta-Resistant HER2/EBV-Specific Cytotoxic T Lymphocytes [NCIt concept]
- Canertinib Dihydrochloride [NCIt concept]
- Cinrebafusp Alfa [NCIt concept]
- Copper Cu 64-DOTA-Trastuzumab [NCIt concept]
- Disitamab Vedotin [NCIt concept]
- EGFR/HER2 Inhibitor ABT-101 [NCIt concept]
- EGFR/HER2 Inhibitor AV-412 [NCIt concept]
- EGFR/HER2 Inhibitor ORIC-114 [NCIt concept]
- EGFR/HER2 Inhibitor TAS2940 [NCIt concept]
- EGFR/HER2 Kinase Inhibitor TAK-285 [NCIt concept]
- EGFR/HER2 Mutant-selective Inhibitor BAY2927088 [NCIt concept]
- Engineered Toxin Body Targeting HER2 MT-5111 [NCIt concept]
- Ertumaxomab [NCIt concept]
- Ex Vivo-Expanded HER2-Specific T Cells [NCIt concept]
- Fencabtagene Autoleucel [NCIt concept]
- GP2 Peptide/GM-CSF Vaccine [NCIt concept]
- Gallium Ga 68 AIP-301 [NCIt concept]
- HDAC/EGFR/HER2 Inhibitor CUDC-101 [NCIt concept]
- HER-2/PD-L1-targeting CAR-T Cells [NCIt concept]
- HER-2/neu Intracellular Domain Protein [NCIt concept]
- HER-2/neu Peptide Vaccine [NCIt concept]
- HER2 ECD+TM Virus-like Replicon Particles Vaccine AVX901 [NCIt concept]
- HER2 Inhibitor BI 1810631 [NCIt concept]
- HER2 Inhibitor DZD1516 [NCIt concept]
- HER2 Inhibitor ELVN-002 [NCIt concept]
- HER2 Inhibitor SPH5030 [NCIt concept]
- HER2 Inhibitor TAS0728 [NCIt concept]
- HER2 Inhibitor ZN-A-1041 [NCIt concept]
- HER2 Tri-specific Natural Killer Cell Engager DF1001 [NCIt concept]
- HER2-targeted Hypoxia-stimulated CAR T Cells [NCIt concept]
- HER2-targeted Liposomal Doxorubicin Hydrochloride HF158K1 [NCIt concept]
- HER2-targeted Liposomal Doxorubicin Hydrochloride MM-302 [NCIt concept]
- HER2-targeting Antibody Fc Fragment FS102 [NCIt concept]
- HER2/neu Peptide Vaccine GLSI-100 [NCIt concept]
- HER2Bi-Armed Activated T Cells [NCIt concept]
- HLA-A*0201-restricted TRP2-gp100-EphA2-HER2 Multipeptide Vaccine [NCIt concept]
- Hyaluronidase-zzxf/Pertuzumab/Trastuzumab [NCIt concept]
- Hypoxia-activated Prodrug TH-4000 [NCIt concept]
- Indium In 111 CHX-A DTPA Trastuzumab [NCIt concept]
- Iodine I 131 SGMIB-Anti-HER2 CAM-H2 [NCIt concept]
- Lapatinib [NCIt concept]
- Lapatinib Ditosylate [NCIt concept]
- Lapuleucel-T [NCIt concept]
- Lead Pb 212 TCMC-trastuzumab [NCIt concept]
- LmddA-LLO-chHER2 Fusion Protein-secreting Live-attenuated Listeria Cancer Vaccine OST31-164 [NCIt concept]
- Margetuximab [NCIt concept]
- Masoprocol [NCIt concept]
- Modified Vaccinia Ankara (Bavarian Nordic)-HER2 Vaccine [NCIt concept]
- Multi-epitope HER2 Peptide Vaccine H2NVAC [NCIt concept]
- Multi-epitope HER2 Peptide Vaccine TPIV100 [NCIt concept]
- Multi-glioblastoma-peptide-targeting Autologous Dendritic Cell Vaccine ICT-107 [NCIt concept]
- Nelipepimut-S Plus GM-CSF Vaccine [NCIt concept]
- Neratinib [NCIt concept]
- Neratinib Maleate [NCIt concept]
- Pan HER/VEGFR2 Receptor Tyrosine Kinase Inhibitor BMS-690514 [NCIt concept]
- Pan-HER Inhibitor FCN-411 [NCIt concept]
- Pelitinib [NCIt concept]
- Pertuzumab [NCIt concept]
- Pertuzumab Zuvotolimod [NCIt concept]
- Pyrotinib [NCIt concept]
- Recombinant Humanized Anti-HER-2 Bispecific Monoclonal Antibody MBS301 [NCIt concept]
- Synthetic Breast Cancer Peptides-Tetanus Toxoid-Montanide ISA-51 Vaccine [NCIt concept]
- Synthetic Breast Cancer Peptides-Tetanus Toxoid-Poly ICLC Vaccine [NCIt concept]
- TAEK-VAC-HerBy Vaccine [NCIt concept]
- Technetium Tc-99m-MIRC208 [NCIt concept]
- Technetium Tc-99m-MIRC213 [NCIt concept]
- Tesevatinib [NCIt concept]
- Thorium Th 227 Trastuzumab Corixetan [NCIt concept]
- Trastuzumab [NCIt concept]
- Trastuzumab Botidotin [NCIt concept]
- Trastuzumab Deruxtecan [NCIt concept]
- Trastuzumab Duocarmazine [NCIt concept]
- Trastuzumab Emtansine [NCIt concept]
- Trastuzumab Rezetecan [NCIt concept]
- Trastuzumab Vedotin [NCIt concept]
- Trastuzumab/Hyaluronidase-oysk [NCIt concept]
- Trastuzumab/MMAF Antibody-drug Conjugate IKS014 [NCIt concept]
- Trastuzumab/Tesirine Antibody-drug Conjugate ADCT-502 [NCIt concept]
- Zanidatamab [NCIt concept]
- Zenocutuzumab [NCIt concept]
- Zirconium Zr 89 DFO-Pertuzumab [NCIt concept]
- Zirconium Zr 89 Trastuzumab [NCIt concept]
- Zirconium Zr 89-ss-Pertuzumab [NCIt concept]
- dHER2 Vaccine+AS15 Adjuvant [NCIt concept]
- pNGVL3-hICD Vaccine [NCIt concept]
- pNGVL3-hICD Vaccine AST-301 [NCIt concept]
- pUMVC3-IGFBP2-HER2-IGF1R Plasmid DNA Vaccine [NCIt concept]
- pan-HER Kinase Inhibitor AC480 [NCIt concept]

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