Preferred Label : HER2 Mutant-selective Inhibitor NVL-330;
NCIt synonyms : HER-2 Mutant-selective Inhibitor NVL-330;
NCIt definition : An orally bioavailable mutant-selective inhibitor of the receptor tyrosine kinase
human epidermal growth factor receptor 2 (HER2), with potential antineoplastic activity.
Upon oral administration, HER2 mutant-selective inhibitor NVL-330 targets, binds to,
and inhibits the activity of HER2 oncogenic alterations, including HER2 exon20 insertion
mutations (exon20ins), HER2 activating point mutations, and amplified wild-type HER2.
This prevents HER2-mediated signaling and may lead to cell death in HER2-expressing
tumor cells. HER2, a receptor tyrosine kinase overexpressed on a variety of tumor
cell types, plays an important role in tumor cell proliferation and tumor vascularization.
NVL-330 is able to penetrate the blood-brain-barrier (BBB).;
Molecule name : NVL 330; NVL-330;
Origin ID : C208358;
concept_is_in_subset
- has_target
