NCIt synonyms : erbB Receptor Family; ErbB Receptor Tyrosine Kinase Family; ERBB Receptor-Tyrosine Kinase Family; Epidermal Growth Factor Receptor Family; ERBB Family; Human Epidermal Growth Factor Receptor Family; EGFR Family; EGF Receptor Family; HER Family Receptor; HER Family;
NCIt definition : A family of cellular proteins encoded by the c-erbB genes, including epidermal growth
factor receptor. They are normally expressed in a variety of tissues of epithelial,
mesenchymal, and neuronal origin. They are overexpressed in a significant portion
of adenocarcinomas found at various sites, especially in the breast. Gene amplification
appears to be the predominant method leading to overexpression.;