ErbB Receptor Family Protein

Preferred Label : ErbB Receptor Family Protein;

NCIt synonyms : erbB Receptor Family; ErbB Receptor Tyrosine Kinase Family; ERBB Receptor-Tyrosine Kinase Family; Epidermal Growth Factor Receptor Family; ERBB Family; Human Epidermal Growth Factor Receptor Family; EGFR Family; EGF Receptor Family; HER Family Receptor; HER Family; EGF Receptor-Tyrosine Kinase Family;

NCIt definition : A family of cellular proteins encoded by the c-erbB genes, including epidermal growth factor receptor. They are normally expressed in a variety of tissues of epithelial, mesenchymal, and neuronal origin. They are overexpressed in a significant portion of adenocarcinomas found at various sites, especially in the breast. Gene amplification appears to be the predominant method leading to overexpression.;

Détails

Origin ID

C18506;

UMLS CUI

C3812393;

Automatic exact mappings (from CISMeF team)
- ErbB Receptors [MeSH Descriptor]
- HER Family Receptors [MeSH concept]
Biochemical function of gene products
- ERBB2 Gene Product [NCIt concept]
- Epidermal Growth Factor Receptor [NCIt concept]
- Receptor Tyrosine-Protein Kinase ErbB-4 [NCIt concept]
- Receptor Tyrosine-Protein Kinase erbB-2 [NCIt concept]
- Receptor Tyrosine-Protein Kinase erbB-2 Carboxyl Terminal Fragment [NCIt concept]
- Receptor Tyrosine-Protein Kinase erbB-3 [NCIt concept]
- Soluble Receptor Tyrosine-Protein Kinase erbB-2 [NCIt concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
- Receptor [UMLS semantic type]
UMLS correspondences (same concept)
- ErbB Receptors [MeSH Descriptor]
- ErbB Receptors [MeSH concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Enzyme Gene [NCIt concept]
- Kinase Family Gene [NCIt concept]
- Ligand Binding Protein Gene [NCIt concept]
- Receptor Gene [NCIt concept]
- Receptor Tyrosine Kinase Gene [NCIt concept]
- Transferase Gene [NCIt concept]
gene_product_has_associated_anatomy
- Plasma Membrane [NCIt concept]
gene_product_has_biochemical_function
- Cell Surface Receptor [NCIt concept]
- Growth Factor Receptor [NCIt concept]
- Receptor Tyrosine Kinase [NCIt concept]
gene_product_has_chemical_classification
- Transmembrane Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- Transmembrane Domain [NCIt concept]
gene_product_plays_role_in_biological_process
- Cell Growth Regulation [NCIt concept]
- Receptor Signaling [NCIt concept]

Position du mot-clé dans l'(les) arborescence(s) :

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