Soluble Receptor Tyrosine-Protein Kinase erbB-2

Preferred Label : Soluble Receptor Tyrosine-Protein Kinase erbB-2;

NCIt synonyms : ERBB2; Herstatin; sErbB-2; ERBB2 ECD; HER2 Extracellular Domain; Soluble ERBB2; Soluble ErbB-2; HER2 ECD; Soluble ERBB-2 Protein; ERBB2 Extracellular Domain; sERBB2;

NCIt definition : Soluble receptor tyrosine-protein kinase erbB-2 is encoded by the human ERBB2 gene. This protein may be involved in binding to receptor tyrosine-protein kinase erbB-2, which leads to disruption of dimer formation, reduced receptor phosphorylation, and inhibition of cell growth.;

Details

Origin ID

C18435;

UMLS CUI

C1506592;

Automatic exact mappings (from CISMeF team)
- Erb-b2 receptor tyrosine kinase 2 [OMIM gene]
- erb-b2 receptor tyrosine kinase 2 [ORDO Gene]
- genes, erbB-2 [MeSH Descriptor]
- genes, erbB-2 [MeSH concept]
Currated CISMeF NLP mapping
- herstatin [MeSH concept]
- herstatin [MeSH Supplementary Concept]
OMIM relation
- Erb-b2 receptor tyrosine kinase 2 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- herstatin protein, human [MeSH concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- ERBB2 Gene [NCIt concept]
- Enzyme Gene [NCIt concept]
- Kinase Family Gene [NCIt concept]
- Ligand Binding Protein Gene [NCIt concept]
- Receptor Gene [NCIt concept]
- Receptor Tyrosine Kinase Gene [NCIt concept]
- Transferase Gene [NCIt concept]
gene_product_has_structural_domain_or_motif
- Ligand Binding Domain [NCIt concept]
gene_product_is_biomarker_type
- Tumor Marker [NCIt concept]
gene_product_plays_role_in_biological_process
- Cell Growth Regulation [NCIt concept]
- Ligand Binding [NCIt concept]

Keyword's position in hierarchy(ies) :

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