ErbB Receptors

Preferred Label : ErbB Receptors;

MeSH definition : A family of structurally-related cell-surface receptors that signal through an intrinsic PROTEIN-TYROSINE KINASE. The receptors are activated upon binding of specific ligands which include EPIDERMAL GROWTH FACTORS, and NEUREGULINS.; A family of structurally related cell-surface receptors that signal through an intrinsic PROTEIN-TYROSINE KINASE. The receptors are activated upon binding of specific ligands which include EPIDERMAL GROWTH FACTORS, and NEUREGULINS.;

MeSH synonym : Receptors, ErbB; Transforming Growth Factor alpha Receptor; Urogastrone Receptor; Receptor, TGF-alpha; Receptor, TGF alpha; Epidermal Growth Factor Receptor Kinase; Epidermal Growth Factor Receptor Protein-Tyrosine Kinase; Epidermal Growth Factor Receptor Protein Tyrosine Kinase; Receptor, Urogastrone; Receptor, Transforming-Growth Factor alpha; Receptor, Transforming Growth Factor alpha; TGF-alpha Receptor; ErbB Receptor; Receptor, ErbB;

CISMeF synonym : EGF Receptors; Erb b2 Receptor Tyrosine Kinases; Erb-b2 Receptor Tyrosine Kinases; HER Family Receptors;

MeSH hyponym : Family Receptors, HER; Receptors, HER Family; ErbB-1 Receptor; Receptor, ErbB 1; Proto-oncogene c-ErbB-1 Protein; Proto oncogene c ErbB 1 Protein; c-ErbB-1 Protein, Proto-oncogene; c-erbB-1 Protein; c erbB 1 Protein; Receptor Tyrosine-protein Kinase erbB-1; Receptor Tyrosine protein Kinase erbB 1; erbB-1 Proto-Oncogene Protein; Proto-Oncogene Protein, erbB-1; erbB 1 Proto Oncogene Protein; Receptors, EGF; Epidermal Growth Factor Receptor; Receptors, Epidermal Growth Factor-Urogastrone; Receptors, Epidermal Growth Factor Urogastrone; Receptor, EGF; Receptors, Epidermal Growth Factor; Epidermal Growth Factor Receptor Family Proteins; EGF Receptor; Receptor, Epidermal Growth Factor; HER Family Receptor; Family Receptor, HER; Receptor, HER Family; Epidermal Growth Factor Receptor Family Protein;

Registry Number MeSH : EC 2.7.10.1;

UNII : EC 2.7.10.1;

Details

Origin ID

D066246;

UMLS CUI

C3812393;

ATC code(s)
- Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors [ATC Code]
Allowable qualifiers
- administration and dosage [MeSH Qualifier]
- adverse effects [MeSH Qualifier]
- agonists [MeSH Qualifier]
- analysis [MeSH Qualifier]
- antagonists and inhibitors [MeSH Qualifier]
- biosynthesis [MeSH Qualifier]
- blood [MeSH Qualifier]
- cerebrospinal fluid [MeSH Qualifier]
- chemical synthesis [MeSH Qualifier]
- chemistry [MeSH Qualifier]
- classification [MeSH Qualifier]
- contraindications [MeSH Qualifier]
- deficiency [MeSH Qualifier]
- drug effects [MeSH Qualifier]
- economics [MeSH Qualifier]
- genetics [MeSH Qualifier]
- history [MeSH Qualifier]
- immunology [MeSH Qualifier]
- isolation and purification [MeSH Qualifier]
- metabolism [MeSH Qualifier]
- pharmacokinetics [MeSH Qualifier]
- pharmacology [MeSH Qualifier]
- physiology [MeSH Qualifier]
- poisoning [MeSH Qualifier]
- radiation effects [MeSH Qualifier]
- standards [MeSH Qualifier]
- supply and distribution [MeSH Qualifier]
- therapeutic use [MeSH Qualifier]
- toxicity [MeSH Qualifier]
- ultrastructure [MeSH Qualifier]
- urine [MeSH Qualifier]
Automatic exact mappings (from CISMeF team)
- Epidermal Growth Factor Receptor [NCIt concept]
- Epidermal Growth Factor Receptor Measurement [NCIt concept]
- Epidermal growth factor receptor [LOINC component]
- Epidermal growth factor receptor [OMIM gene]
- Epidermal growth factor-urogastrone receptor (substance) [SNOMED CT concept]
- ErbB Receptor Family Protein [NCIt concept]
- epidermal growth factor receptor [ORDO Gene]
- epidermal growth factor receptor [HGNC gene]
Indexing information
- (4-((1-(3-fluorophenyl)methyl)-1H-indazol-5-ylamino)-5-methylpyrrolo(2,1-f)(1,2,4)triazin-6-yl)carbamic acid 3-morpholinylmethyl ester [MeSH Supplementary Concept]
- (6,7-dimethoxyethoxy)quinolin-4-yl-(3-ethynylphenyl)amine [MeSH Supplementary Concept]
- 1-(1-acryloylpyrrolidin-3-yl)-7-(3-methyl-4-(4-methylpiperazin-1-yl)phenylamino)-3-phenyl-3,4-dihydropyrimido(4,5-d)pyrimidin-2(1H)-one [MeSH Supplementary Concept]
- 1-(2-chloroethyl)-1-nitroso-3-methyl-3-((4-(3-chlorophenyl)amino)quinazolin-6-yl)urea [MeSH Supplementary Concept]
- 1-(4-((2-hydroxy-1-phenylethyl)amino)-5,6,7,8-tetrahydropyrido(4',3'-4,5)thieno(2,3-d)pyrimidin-7-yl)-2-propen-1-one [MeSH Supplementary Concept]
- 1-acryloyl-N-(4-(3-chloro-2,4-difluorophenylamino)-7-(2-methoxyethoxy)quinazolin-6-yl)pyrrolidine-2-carboxamide [MeSH Supplementary Concept]
- 1-acryloyl-N-(4-(3-chloro-2-fluorophenylamino)-7-(2-methoxyethoxy)quinazolin-6-yl)pyrrolidine-2-carboxamide [MeSH Supplementary Concept]
- 2-((4-(3-bromophenylamino)quinazolin-6-ylamino)methyl)benzene-1,4-diol [MeSH Supplementary Concept]
- 2-((4-(3-chloro-4-fluorophenylamino)quinazolin-6-ylamino)methyl)benzene-1,4-diol [MeSH Supplementary Concept]
- 2-(benzylsulfinyl)ethyl pyridin-3-ylmethylcarbamodithioate [MeSH Supplementary Concept]
- 4,5-bis(4-fluoroanilino)phthalimide [MeSH Supplementary Concept]
- 4-((3-bromophenyl)amino)-6,7-dimethoxyquinazoline [MeSH Supplementary Concept]
- 4-((3-bromophenyl)amino)-6-(methylamino)pyrimido(5,4-d)pyrimidine [MeSH Supplementary Concept]
- 4-((6-(2-(4-(4-((4-(3-acrylamidophenoxy)-5-chloropyrimidin-2-yl)amino)-3-methoxyphenyl)piperazin-1-yl)acetoxy)hexyl)oxy)-3-(phenylsulfonyl)-1,2,5-oxadiazole 2-oxide [MeSH Supplementary Concept]
- 4-(dimethylamino)-1-(4-(2-hydroxy-1-phenylethyl)amino-5,6,7,8-tetrahydropyrido(4',3'-4,5)thieno(2,3-d)pyrimidin-7-yl)-2-buten-1-one [MeSH Supplementary Concept]
- 6,6'-(2,2'-(4,4'-(4,4'-oxybis(4,1-phenylene)bis(azanediyl))bis(7-methoxyquinazoline-6,4-diyl))bis(oxy)bis(ethane-2,1-diyl))bis(oxy)bis(2-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol) [MeSH Supplementary Concept]
- 6-(3-acetoxymethyl-3-methyltriazenyl)-4-(3'-bromophenylamino)quinazoline [MeSH Supplementary Concept]
- 8-((3-bromophenyl)amino)-3-methyl-3H-imidazo(4,5-g)quinazoline [MeSH Supplementary Concept]
- AEE 788 [MeSH Supplementary Concept]
- AL622 [MeSH Supplementary Concept]
- AST 1306 [MeSH Supplementary Concept]
- EGFR protein, human [MeSH Supplementary Concept]
- EGFR tyrosine kinase inhibitor 324674 [MeSH Supplementary Concept]
- EKB 569 [MeSH Supplementary Concept]
- F90 compound [MeSH Supplementary Concept]
- FR18 compound [MeSH Supplementary Concept]
- H-P-6 peptide [MeSH Supplementary Concept]
- MP 412 [MeSH Supplementary Concept]
- N-((2-(4-amino-6-(3-chloro-4-(pyridin-2-ylmethoxy)phenylamino)pyrimidin-5-yl)oxazol-4-yl)methyl)acrylamide [MeSH Supplementary Concept]
- N-(2-(4-((3-chloro-4-(3-(trifluoromethyl)phenoxy)phenyl)amino)-5H-pyrrolo(3,2-d)pyrimidin-5-yl)ethyl)-3-hydroxy-3-methylbutanamide [MeSH Supplementary Concept]
- N-(2-bromo-5-(trifluoromethyl)phenyl)-6-methoxy-7-(3-(piperidin-1-yl)propoxy)quinazolin-4-amine [MeSH Supplementary Concept]
- N-(3-bromophenyl)-7-methoxy-6-(3-(3-methoxypyrrolidin-1-yl)propoxy)quinazolin-4-amine [MeSH Supplementary Concept]
- N-(3-ethynylphenyl)-6,7-bis(2-methoxyethoxy)quinolin-4-amine [MeSH Supplementary Concept]
- N-(4-((3-bromophenyl)amino)--6-quinazolinyl)-4-(dimethylamino)-2-butenamide [MeSH Supplementary Concept]
- N-(4-((4,5-dichloro-2-fluorophenyl)amino)quinazolin-6-yl)-4-dimethylamino-2-butenamide [MeSH Supplementary Concept]
- N-(4-(3-chloro-4-fluorophenylamino)quinazolin-6-yl)acrylamide [MeSH Supplementary Concept]
- N4-(3-cyclopropyl-1H-pyrazol-5-yl)-5-fluoro-N2-(4-(piperazin-1-yl)phenyl)pyrimidine-2,4-diamine [MeSH Supplementary Concept]
- PKI 166 [MeSH Supplementary Concept]
- RTKI cpd [MeSH Supplementary Concept]
- SKLB1028 [MeSH Supplementary Concept]
- WZ4002 [MeSH Supplementary Concept]
- XL647 [MeSH Supplementary Concept]
- ZR 2003 [MeSH Supplementary Concept]
- asparagyl-tyrosyl-glutaminyl-glutaminyl-asparagine [MeSH Supplementary Concept]
- cochliobolic acid [MeSH Supplementary Concept]
- monoclonal antibody 806 [MeSH Supplementary Concept]
- naamidine A [MeSH Supplementary Concept]
- necitumumab [MeSH Supplementary Concept]
Record concept(s)
- EGF Receptors [MeSH concept]
- ErbB Receptors [MeSH concept]
- HER Family Receptors [MeSH concept]
- Receptor, ErbB-1 [MeSH concept]
Related MeSH Supplementary Concept(s)
- EGFR protein, Anopheles gambiae [MeSH Supplementary Concept]
- EGFR protein, human [MeSH Supplementary Concept]
- EGFR protein, mouse [MeSH Supplementary Concept]
- Sas protein, Drosophila [MeSH Supplementary Concept]
- egfr protein, drosophila [MeSH Supplementary Concept]
- egfr protein, rat [MeSH Supplementary Concept]
- epidermal growth factor receptor (768-775) [MeSH Supplementary Concept]
- epidermal growth factor receptor VIII [MeSH Supplementary Concept]
- epidermal growth factor receptor-neu receptor [MeSH Supplementary Concept]
- let-23 protein, C elegans [MeSH Supplementary Concept]
- secErbB4-26-549 [MeSH Supplementary Concept]
- tripalmitoyl-S-glyceryl-cysteine-epidermal growth factor receptor(516-529) [MeSH Supplementary Concept]
See also
- Cetuximab [MeSH Descriptor]
- epidermal growth factor [MeSH Descriptor]
- genes, erbB-2 [MeSH Descriptor]
- genes, erbb [MeSH Descriptor]
- genes, erbb-1 [MeSH Descriptor]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
- Receptor [UMLS semantic type]
UMLS correspondences (same concept)
- ErbB Receptor Family Protein [NCIt concept]

Keyword's position in hierarchy(ies) :

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