receptor, erbB-2

Preferred Label : receptor, erbB-2;

MeSH definition : A cell surface protein-tyrosine kinase receptor that is overexpressed in a variety of ADENOCARCINOMAS. It has extensive homology to and heterodimerizes with the EGF RECEPTOR, the ERBB-3 RECEPTOR, and the ERBB-4 RECEPTOR. Activation of the erbB-2 receptor occurs through heterodimer formation with a ligand-bound erbB receptor family member.;

MeSH synonym : proto oncogene protein her 2; oncogene protein her 2; proto oncogene proteins c erbb 2; receptor, neu; proto-oncogene protein p185(neu); erbb 2 receptor protein tyrosine kinase; erbb-2 proto-oncogene protein; erbb-2 receptor; receptors, erbb-2; her-2 proto-oncogene protein; p185(c-neu); neu proto-oncogene protein; proto-oncogene protein, neu; neu proto oncogene protein; neu receptor; oncogene protein her-2; proto-oncogene protein her-2; erbb-2 receptor protein-tyrosine kinase; proto-oncogene proteins c-erbb-2; erbb-2 receptors; c-erbb-2 protein; c erbb 2 protein; proto-oncogene protein, erbb-2; erbb 2 proto oncogene protein; her 2 proto oncogene protein; proto-oncogene protein, her-2; p185erbB2 Protein; Proto-oncogene Protein Neu; Tyrosine Kinase-type Cell Surface Receptor HER2; Tyrosine Kinase type Cell Surface Receptor HER2; Antigens, CD340; CD340 Antigens; CD340 Antigen; Metastatic Lymph Node Gene 19 Protein; Erb-b2 Receptor Tyrosine Kinases; Erb b2 Receptor Tyrosine Kinases;

CISMeF synonym : EC 2.7.1.112; receptors, erbb 2; receptor, erbB 2; Protein, p185erbB2; Proto oncogene c ErbB 2; Protein Neu, Proto-oncogene; Proto oncogene Protein Neu; Antigen, CD340; Neu, Proto-oncogene Protein; Proto-oncogene c-ErbB-2; c-ErbB-2, Proto-oncogene;

Registry Number MeSH : EC 2.7.10.1;

Wikipedia link : https://en.wikipedia.org/wiki/Receptor, erbb-2;

Is substance : O;

UNII : EC 2.7.10.1;

Details

Origin ID

D018719;

UMLS CUI

C0069515;

ATC code(s)
- Human epidermal growth factor receptor 2 (HER2) tyrosine kinase inhibitors [ATC Code]
Allowable qualifiers
- administration and dosage [MeSH Qualifier]
- agonists [MeSH Qualifier]
- analysis [MeSH Qualifier]
- antagonists and inhibitors [MeSH Qualifier]
- biosynthesis [MeSH Qualifier]
- blood [MeSH Qualifier]
- chemistry [MeSH Qualifier]
- classification [MeSH Qualifier]
- contraindications [MeSH Qualifier]
- deficiency [MeSH Qualifier]
- drug effects [MeSH Qualifier]
- genetics [MeSH Qualifier]
- history [MeSH Qualifier]
- immunology [MeSH Qualifier]
- isolation and purification [MeSH Qualifier]
- metabolism [MeSH Qualifier]
- physiology [MeSH Qualifier]
- radiation effects [MeSH Qualifier]
- therapeutic use [MeSH Qualifier]
- ultrastructure [MeSH Qualifier]
Indexing information
- 1-acryloyl-N-(4-(3-chloro-2,4-difluorophenylamino)-7-(2-methoxyethoxy)quinazolin-6-yl)pyrrolidine-2-carboxamide [MeSH Supplementary Concept]
- 1-acryloyl-N-(4-(3-chloro-2-fluorophenylamino)-7-(2-methoxyethoxy)quinazolin-6-yl)pyrrolidine-2-carboxamide [MeSH Supplementary Concept]
- 2-methoxy-N-(3-(4-((3-methyl-4-((6-methyl-3-pyridinyl)oxy)phenyl)amino)-6-quinazolinyl)-2-propenyl)acetamide [MeSH Supplementary Concept]
- HER-2-derived peptide 884-899 [MeSH Supplementary Concept]
- Lcn2 protein, rat [MeSH Supplementary Concept]
- MP 412 [MeSH Supplementary Concept]
- XL647 [MeSH Supplementary Concept]
- herstatin [MeSH Supplementary Concept]
- pertuzumab [MeSH Supplementary Concept]
- pertuzumab [MeSH Supplementary Concept]
Record concept(s)
- receptor, erbB-2 [MeSH concept]
Related MeSH Supplementary Concept(s)
- 111In-benzyl-DTPA-ZHER2:342 [MeSH Supplementary Concept]
- ERBB2 protein, human [MeSH Supplementary Concept]
- Erbb2 protein, mouse [MeSH Supplementary Concept]
- Erbb2 protein, rat [MeSH Supplementary Concept]
- GD5 protein, recombinant [MeSH Supplementary Concept]
- HER-2 protein (435-443) [MeSH Supplementary Concept]
- HER-2 protein (776-790) [MeSH Supplementary Concept]
- HER2 peptide (369-377) [MeSH Supplementary Concept]
- HER2(776-788) [MeSH Supplementary Concept]
- HER2-neu-derived peptide (654-662) [MeSH Supplementary Concept]
- HER2-neu-derived peptide (780-786) [MeSH Supplementary Concept]
- HER2p63 peptide [MeSH Supplementary Concept]
- epidermal growth factor receptor-neu receptor [MeSH Supplementary Concept]
See also
- Trastuzumab [MeSH Descriptor]
- genes, erbB-2 [MeSH Descriptor]
- neuregulins [MeSH Descriptor]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
- Receptor [UMLS semantic type]
UMLS correspondences (same concept)
- HER2 [LOINC component]
- Oncogene protein HER-2/neu (substance) [SNOMED CT concept]
- Receptor tyrosine-protein kinase erbB-2 (substance) [SNOMED CT concept]
- oncogene protein her-2/neu [SNOMED Notion]

Keyword's position in hierarchy(ies) :

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