Preferred Label : Pemetrexed;
MeSH definition : A guanine-derived ANTINEOPLASTIC AGENT that functions as a NUCLEIC ACID SYNTHESIS
INHIBITOR through its binding to, and inhibition of, THYMIDYLATE SYNTHASE.;
MeSH synonym : MTA; N-(4-(2-(2-amino-3,4-dihydro-4-oxo-7H-pyrrolo(2,3-d)pyrimdin-5-yl)ethyl)benzoyl)glutamic
acid;
MeSH hyponym : Pemetrexed Disodium; LY 231514; ALIMTA; Disodium, Pemetrexed; 231514, LY; LY-231,514; LY231514; LY 231,514; 231,514, LY; LY-231514;
MeSH CAS label : L-Glutamic acid, N-(4-(2-(2-amino-4,7-dihydro-4-oxo-1H-pyrrolo(2,3-d)pyrimidin-5-yl)ethyl)benzoyl)-;
MeSH Related Number : 137281-23-3 (pemetrexed); 2PKU919BA9;
Wikipedia link : https://en.wikipedia.org/wiki/Pemetrexed;
Is substance : O;
UNII : 04Q9AIZ7NO;
Origin ID : D000068437;
UMLS CUI : C0210657;
ATC code(s)
- Allowable qualifiers
- Automatic exact mappings (from CISMeF team)
- Pharmacological action(s)
- Record concept(s)
- See also inter- (CISMeF)
- Semantic type(s)
- UMLS correspondences (same concept)
- Validated automatic mappings to BTNT
A guanine-derived ANTINEOPLASTIC AGENT that functions as a NUCLEIC ACID SYNTHESIS
INHIBITOR through its binding to, and inhibition of, THYMIDYLATE SYNTHASE.
https://www.ema.europa.eu/en/medicines/human/EPAR/pemetrexed-baxter
2023
false
false
false
Netherlands
French
English
treatment outcome
syndication feed
summary of product characteristics
package leaflet
drug evaluation
drug approval
europe
Pemetrexed
Pemetrexed
pemetrexed
Malignant Pleural Mesothelioma
carcinoma, non-small-cell lung
drugs, generic
antineoplastic combined chemotherapy protocols
cisplatin
Cisplatin/Pemetrexed Regimen
infusions, intravenous
antimetabolites, antineoplastic
antimetabolites, antineoplastic
drug interactions
pregnancy
breast feeding
drug evaluation, preclinical
Unresectable Pleural Malignant Mesothelioma
---
https://www.has-sante.fr/jcms/p_3320519/fr/pemetrexed-sun-mesotheliome-pleural-malin-non-resecable-pemetrexed
2022
false
false
false
France
evaluation of the transparency committee
mesothelioma, malignant
Mesothelioma, Malignant
Malignant mesothelioma
Pemetrexed
Malignant Pleural Mesothelioma
---
https://www.has-sante.fr/jcms/p_3230201/fr/pemetrexed-ever-pharma
2021
false
false
false
France
pemetrexed
insurance, health, reimbursement
infusions, intravenous
antineoplastic agents
evaluation of the transparency committee
Pemetrexed
---
https://www.has-sante.fr/jcms/p_3236104/fr/pemetrexed-reddy-pharma
2021
false
false
false
France
treatment outcome
insurance, health, reimbursement
antineoplastic agents
folic acid antagonists
pemetrexed
mesothelioma
pleural neoplasms
carcinoma, non-small-cell lung
bronchial neoplasms
infusions, intravenous
evaluation of the transparency committee
Pemetrexed
---
https://www.has-sante.fr/jcms/p_3236434/fr/pemetrexed-eg
2021
false
false
false
France
pemetrexed
infusions, intravenous
treatment outcome
insurance, health, reimbursement
antineoplastic agents
mesothelioma
pleural neoplasms
carcinoma, non-small-cell lung
bronchial neoplasms
evaluation of the transparency committee
Pemetrexed
---
https://www.has-sante.fr/jcms/p_3236107/fr/pemetrexed-accord
2021
false
false
false
France
treatment outcome
insurance, health, reimbursement
folic acid antagonists
antineoplastic agents
bronchial neoplasms
pleural neoplasms
mesothelioma
infusions, intravenous
carcinoma, non-small-cell lung
pemetrexed
evaluation of the transparency committee
Pemetrexed
---
https://www.has-sante.fr/jcms/p_3302602/fr/pemetrexed-sun-1000-mg-pemetrexed
2021
France
evaluation of the transparency committee
Pemetrexed
registries
---
https://www.has-sante.fr/jcms/p_3263918/fr/pemetrexed-hospira-pemetrexed
2021
false
false
false
France
Pemetrexed
treatment outcome
insurance, health, reimbursement
pemetrexed
infusions, intravenous
bronchial neoplasms
carcinoma, non-small-cell lung
antimetabolites, antineoplastic
mesothelioma
pleural neoplasms
Pleural Malignant Mesothelioma
evaluation of the transparency committee
---
https://www.has-sante.fr/jcms/p_3202248/fr/pemetrexed-fresenius-kabi
2020
false
false
false
France
infusions, intravenous
pemetrexed
antineoplastic agents
folic acid antagonists
Pemetrexed Fresenius Kabi 25mg/ml concentrate for solution for infusion
evaluation of the transparency committee
Pemetrexed
---
https://www.has-sante.fr/jcms/p_3182799/fr/pemetrexed-sandoz
2020
false
false
false
France
pemetrexed
Unresectable Pleural Malignant Mesothelioma
pleural neoplasms
antineoplastic agents
antineoplastic combined chemotherapy protocols
carcinoma, non-small-cell lung
treatment outcome
insurance, health, reimbursement
neoplasm metastasis
mesothelioma
evaluation of the transparency committee
Pemetrexed
---
https://www.has-sante.fr/portail/jcms/c_2894244/fr/pemetrexed-mylan
2019
false
false
false
France
French
Pemetrexed
evaluation of the transparency committee
antineoplastic agents
pemetrexed
infusions, intravenous
carcinoma, non-small-cell lung
Pleural Malignant Mesothelioma
treatment outcome
---
https://www.has-sante.fr/jcms/p_3119792/fr/pemetrexed-ohre-pharma
2019
false
false
false
France
infusions, intravenous
pemetrexed
insurance, health, reimbursement
treatment outcome
antimetabolites, antineoplastic
mesothelioma
pleural neoplasms
Unresectable Pleural Malignant Mesothelioma
carcinoma, non-small-cell lung
evaluation of the transparency committee
Pemetrexed
---
https://www.has-sante.fr/jcms/p_3124684/fr/pemetrexed-reddy-pharma
2019
false
false
false
France
French
evaluation of the transparency committee
drugs, generic
Pemetrexed
family characteristics
device, nos
Set, Psychology
ALIMTA
Pemetrexed
generations
devices
equipment and supplies
---
https://www.has-sante.fr/portail/jcms/c_2896735/en/pemetrexed-zentiva
2018
false
false
false
France
evaluation of the transparency committee
Pemetrexed
---
http://www.pharmactuel.com/index.php/pharmactuel/article/view/1204
2018
false
false
false
Canada
French
osimertinib
due to
Pemetrexed
mutation
Chemotherapy
"u" lymphocyte
platinum
receptors, opioid, mu
platinum, nos
neoplasm, malignant
Cell
carcinoma, non-small-cell lung
small cell lung carcinoma
drug therapy
base, nos
chemotherapy, nos
treaties
Lung cancer
chemotherapy
small cell lung carcinoma
international cooperation
piperazines
ErbB Receptors
acrylamides
aniline compounds
acrylamides
aniline compounds
---
https://www.ema.europa.eu/medicines/human/EPAR/pemetrexed-krka
2018
false
United Kingdom
English
French
syndication feed
drugs, generic
Pemetrexed
Pemetrexed
Product containing pemetrexed (medicinal product)
Unresectable Pleural Malignant Mesothelioma
antineoplastic combined chemotherapy protocols
Cisplatin/Pemetrexed Regimen
antimetabolites, antineoplastic
antineoplastic agents
folic acid antagonists
mesothelioma
carcinoma, non-small-cell lung
thymidylate synthase
treatment outcome
drug approval
infusions, intravenous
pleural neoplasms
continuity of patient care
drug interactions
pregnancy
breast feeding
drug evaluation, preclinical
pemetrexed
package leaflet
summary of product characteristics
drug evaluation
---
https://www.ema.europa.eu/medicines/human/EPAR/Pemetrexed-Hospira-UK-Limited
2017
false
United Kingdom
English
French
syndication feed
drugs, generic
Pemetrexed
Pemetrexed
Product containing pemetrexed (medicinal product)
antimetabolites, antineoplastic
antineoplastic agents
folic acid antagonists
mesothelioma
carcinoma, non-small-cell lung
thymidylate synthase
treatment outcome
drug approval
infusions, intravenous
pleural neoplasms
continuity of patient care
drug interactions
pregnancy
breast feeding
drug evaluation, preclinical
pemetrexed
package leaflet
summary of product characteristics
drug evaluation
---
https://www.has-sante.fr/portail/jcms/c_2788609/fr/pemetrexed-hospira-uk-limited
2017
false
false
false
France
French
evaluation of the transparency committee
Pemetrexed
---
https://www.ema.europa.eu/medicines/human/EPAR/pemetrexed-fresenius-kabi
2016
false
United Kingdom
English
French
syndication feed
Nonsquamous nonsmall cell neoplasm of lung (disorder)
folic acid antagonists
Product containing precisely pemetrexed (as pemetrexed disodium) 500 milligram/1 vial
powder for conventional release solution for injection (clinical drug)
Product containing precisely pemetrexed (as pemetrexed disodium) 100 milligram/1 vial
powder for conventional release solution for injection (clinical drug)
Pleural Malignant Mesothelioma
drugs, generic
Pemetrexed
Pemetrexed
Pemetrexed Fresenius Kabi 25mg/ml concentrate for solution for infusion
antimetabolites, antineoplastic
antineoplastic agents
folic acid antagonists
mesothelioma
carcinoma, non-small-cell lung
thymidylate synthase
treatment outcome
drug approval
drug evaluation
infusions, intravenous
pleural neoplasms
continuity of patient care
drug interactions
pregnancy
breast feeding
drug evaluation, preclinical
pemetrexed
package leaflet
summary of product characteristics
drug evaluation
---
https://www.ema.europa.eu/medicines/human/EPAR/Ciambra
2016
false
United Kingdom
English
French
syndication feed
Nonsquamous nonsmall cell neoplasm of lung (disorder)
folic acid antagonists
Product containing precisely pemetrexed (as pemetrexed disodium) 500 milligram/1 vial
powder for conventional release solution for injection (clinical drug)
Product containing precisely pemetrexed (as pemetrexed disodium) 100 milligram/1 vial
powder for conventional release solution for injection (clinical drug)
Pleural Malignant Mesothelioma
drugs, generic
Pemetrexed
Pemetrexed
antimetabolites, antineoplastic
antineoplastic agents
folic acid antagonists
mesothelioma
carcinoma, non-small-cell lung
thymidylate synthase
treatment outcome
drug approval
drug evaluation
infusions, intravenous
pleural neoplasms
continuity of patient care
drug interactions
pregnancy
breast feeding
drug evaluation, preclinical
pemetrexed
package leaflet
summary of product characteristics
drug evaluation
---
http://www.has-sante.fr/portail/jcms/c_2621477/fr/alimta
2016
false
France
French
Pemetrexed
survival analysis
Progression-Free survival
antineoplastic combined chemotherapy protocols
cisplatin
Locally Advanced Malignant Neoplasm
neoplasm recurrence, local
maintenance chemotherapy
pemetrexed
antimetabolites, antineoplastic
carcinoma, non-small-cell lung
neoplasm metastasis
infusions, intravenous
treatment outcome
evaluation of the transparency committee
disease-free survival
---
http://www.has-sante.fr/portail/jcms/c_2628546/fr/alimta-mesotheliome
2016
false
France
French
Pemetrexed
antineoplastic combined chemotherapy protocols
treatment outcome
Pleural Malignant Mesothelioma
Unresectable Malignant Neoplasm
mesothelioma
pleural neoplasms
infusions, intravenous
antimetabolites, antineoplastic
cisplatin
survival analysis
adult
aged
antineoplastic agents
pemetrexed
guidelines for drug use
---
https://www.ema.europa.eu/medicines/human/EPAR/Pemetrexed-Accord
2016
false
United Kingdom
English
French
syndication feed
Nonsquamous nonsmall cell neoplasm of lung (disorder)
folic acid antagonists
Product containing precisely pemetrexed (as pemetrexed disodium) 500 milligram/1 vial
powder for conventional release solution for injection (clinical drug)
Product containing precisely pemetrexed (as pemetrexed disodium) 100 milligram/1 vial
powder for conventional release solution for injection (clinical drug)
Pleural Malignant Mesothelioma
drugs, generic
Pemetrexed
Pemetrexed
antimetabolites, antineoplastic
antineoplastic agents
folic acid antagonists
mesothelioma
carcinoma, non-small-cell lung
thymidylate synthase
treatment outcome
drug approval
drug evaluation
infusions, intravenous
pleural neoplasms
continuity of patient care
drug interactions
pregnancy
breast feeding
drug evaluation, preclinical
pemetrexed
package leaflet
summary of product characteristics
drug evaluation
---
https://www.ema.europa.eu/medicines/human/EPAR/armisarte-previously-pemetrexed-actavis
2016
false
United Kingdom
English
French
syndication feed
folic acid antagonists
antimetabolites, antineoplastic
Pleural Malignant Mesothelioma
Nonsquamous nonsmall cell neoplasm of lung (disorder)
Product containing pemetrexed (medicinal product)
Pemetrexed
Pemetrexed
antimetabolites, antineoplastic
antineoplastic agents
folic acid antagonists
mesothelioma
carcinoma, non-small-cell lung
thymidylate synthase
treatment outcome
drug approval
infusions, intravenous
pleural neoplasms
continuity of patient care
drug interactions
pregnancy
breast feeding
drug evaluation, preclinical
pemetrexed
package leaflet
summary of product characteristics
drug evaluation
---
http://www.has-sante.fr/portail/jcms/c_2678847/fr/pemetrexed-fresenius-kabi
2016
false
false
false
France
French
evaluation of the transparency committee
drugs, generic
infusions, intravenous
Pemetrexed
---
https://www.ema.europa.eu/medicines/human/EPAR/Pemetrexed-Hospira
2015
false
United Kingdom
English
French
syndication feed
drugs, generic
Pemetrexed
Pemetrexed
antimetabolites, antineoplastic
antineoplastic agents
folic acid antagonists
mesothelioma
carcinoma, non-small-cell lung
thymidylate synthase
treatment outcome
drug approval
drug labeling
drug evaluation
infusions, intravenous
pleural neoplasms
continuity of patient care
drug interactions
pregnancy
breast feeding
drug evaluation, preclinical
pemetrexed
package leaflet
summary of product characteristics
drug evaluation
---
https://www.ema.europa.eu/medicines/human/EPAR/Pemetrexed-Sandoz
2015
false
United Kingdom
English
French
syndication feed
Pemetrexed
Pemetrexed
antimetabolites, antineoplastic
antineoplastic agents
folic acid antagonists
mesothelioma
carcinoma, non-small-cell lung
thymidylate synthase
treatment outcome
drug approval
drug labeling
drug evaluation
infusions, intravenous
pleural neoplasms
continuity of patient care
drug interactions
pregnancy
breast feeding
drug evaluation, preclinical
pemetrexed
package leaflet
summary of product characteristics
drug evaluation
---
https://www.ema.europa.eu/medicines/human/EPAR/Pemetrexed-medac
2015
false
United Kingdom
English
French
syndication feed
drugs, generic
Pleural Malignant Mesothelioma
Advanced Malignant Neoplasm
Nonsquamous nonsmall cell neoplasm of lung (disorder)
Pemetrexed
Pemetrexed
antimetabolites, antineoplastic
antineoplastic agents
folic acid antagonists
mesothelioma
carcinoma, non-small-cell lung
thymidylate synthase
treatment outcome
drug approval
drug labeling
drug evaluation
infusions, intravenous
pleural neoplasms
continuity of patient care
drug interactions
pregnancy
breast feeding
drug evaluation, preclinical
pemetrexed
package leaflet
summary of product characteristics
drug evaluation
---
http://www.pharmactuel.com/index.php/pharmactuel/article/view/942
2014
false
Canada
French
lung neoplasms
carcinoma, non-small-cell lung
journal article
lung neoplasms
carcinoma, non-small-cell lung
lung neoplasms
carcinoma, non-small-cell lung
antineoplastic agents
antibodies, monoclonal, humanized
angiogenesis inhibitors
protein kinase inhibitors
pyrazoles
pyridines
Erlotinib Hydrochloride
Pemetrexed
Bevacizumab
Gefitinib
Crizotinib
---
https://www.ema.europa.eu/medicines/human/EPAR/Alimta
2012
false
United Kingdom
English
French
syndication feed
Pemetrexed
Pemetrexed
antimetabolites, antineoplastic
antineoplastic agents
folic acid antagonists
mesothelioma
carcinoma, non-small-cell lung
thymidylate synthase
treatment outcome
drug approval
drug labeling
drug evaluation
infusions, intravenous
pleural neoplasms
continuity of patient care
drug interactions
pregnancy
breast feeding
drug evaluation, preclinical
pemetrexed
package leaflet
summary of product characteristics
drug evaluation
---
http://www.cochrane.org/fr/CD005574
http://www.cochrane.org/fr/CD005574/le-pemetrexed-disodium-nouveau-medicament-anticancereux-augmente-significativement-la-duree-de-survie-tout-en-soulageant-les-symptomes-du-mesotheliome
2012
false
true
false
United Kingdom
France
pleural neoplasms
treatment outcome
antineoplastic combined chemotherapy protocols
comparative study
Pemetrexed
review of literature
french abstract
mesothelioma
antineoplastic agents
cisplatin
---
https://www.inesss.qc.ca/fileadmin/doc/INESSS/Inscription_medicaments/Avis_au_ministre/ProjetPilote_Cancer/Document_synthese_final_CAV.pdf
2011
false
Canada
French
Pemetrexed
Erlotinib Hydrochloride
Everolimus
drug evaluation
drug evaluation
antineoplastic agents
Cost-Benefit analysis
treatment outcome
insurance, health, reimbursement
carcinoma, renal cell
neoplasm metastasis
pemetrexed
lung neoplasms
canada
gefitinib
everolimus
erlotinib
survival analysis
technical report
drug information
Gefitinib
---
http://www.has-sante.fr/portail/jcms/c_954773/alimta
2010
false
France
French
Pemetrexed
guidelines for drug use
maintenance chemotherapy
pemetrexed
antimetabolites, antineoplastic
carcinoma, non-small-cell lung
neoplasm metastasis
infusions, intravenous
treatment outcome
evaluation of the transparency committee
---
http://www.has-sante.fr/portail/jcms/c_979754/alimta-pemetrexed-antifolate
http://www.has-sante.fr/portail/upload/docs/application/pdf/2010-06/alimta_-_ct-7892.pdf
2010
false
France
French
Pemetrexed
maintenance chemotherapy
carcinoma, non-small-cell lung
neoplasm metastasis
infusions, intravenous
antimetabolites, antineoplastic
pemetrexed
treatment outcome
evaluation of the transparency committee
guidelines for drug use
---
http://agence-prd.ansm.sante.fr/php/ecodex/extrait.php?specid=67713231
2008
false
France
French
Pemetrexed
infusions, parenteral
thymidylate synthase
pemetrexed
drug information
---
http://agence-prd.ansm.sante.fr/php/ecodex/extrait.php?specid=67323808
2008
false
France
French
Pemetrexed
thymidylate synthase
infusions, parenteral
pemetrexed
drug information
---
http://www.e-cancer.fr/content/download/85854/873644/file/ptt_alimta_digestif.pdf
2007
true
France
French
Pemetrexed
antineoplastic agents
antimetabolites, antineoplastic
pleural neoplasms
mesothelioma
peritoneal neoplasms
rare diseases
carcinoma, non-small-cell lung
thymidylate synthase
pemetrexed
guidelines for drug use
summary of product characteristics
drug evaluation
evaluation of the transparency committee
---
http://www.has-sante.fr/portail/display.jsp?id=c_245682
2005
false
France
French
Pemetrexed
antineoplastic agents
pemetrexed
guidelines for drug use
---
http://www.has-sante.fr/portail/display.jsp?id=c_400204
2005
false
France
French
Pemetrexed
folic acid antagonists
antineoplastic agents
antimetabolites, antineoplastic
thymidylate synthase
carcinoma, non-small-cell lung
bronchial neoplasms
infusions, intravenous
pleural neoplasms
mesothelioma
treatment outcome
pemetrexed
evaluation of the transparency committee
---
