folic acid antagonists

Preferred Label : folic acid antagonists;

MeSH definition : Inhibitors of the enzyme, dihydrofolate reductase (TETRAHYDROFOLATE DEHYDROGENASE), which converts dihydrofolate (FH2) to tetrahydrofolate (FH4). They are frequently used in cancer chemotherapy. (From AMA, Drug Evaluations Annual, 1994, p2033);

MeSH synonym : antifolates; acid antagonists, folic; antagonists, folic acid; Dihydrofolate Reductase Inhibitors; Inhibitors, Dihydrofolate Reductase; Reductase Inhibitors, Dihydrofolate; Antifolate; Folic Acid Antagonist; Acid Antagonist, Folic; Antagonist, Folic Acid; Dihydrofolate Reductase Inhibitor; Inhibitor, Dihydrofolate Reductase; Reductase Inhibitor, Dihydrofolate;

MeSH Hyperonym : Folic Acid Metabolism Inhibitors;

MeSH annotation : DF: FOLIC ACID ANTAG;

Is substance : O;

action pharmacologique : O;

Details

Origin ID

D005493;

UMLS CUI

C0016411;

ATC code(s)
- folic acid analogues [ATC Code]
- pralatrexate [ATC Code]
Allowable qualifiers
- administration and dosage [MeSH Qualifier]
- adverse effects [MeSH Qualifier]
- analysis [MeSH Qualifier]
- blood [MeSH Qualifier]
- cerebrospinal fluid [MeSH Qualifier]
- chemical synthesis [MeSH Qualifier]
- chemistry [MeSH Qualifier]
- classification [MeSH Qualifier]
- contraindications [MeSH Qualifier]
- economics [MeSH Qualifier]
- history [MeSH Qualifier]
- immunology [MeSH Qualifier]
- isolation and purification [MeSH Qualifier]
- metabolism [MeSH Qualifier]
- pharmacokinetics [MeSH Qualifier]
- pharmacology [MeSH Qualifier]
- poisoning [MeSH Qualifier]
- radiation effects [MeSH Qualifier]
- standards [MeSH Qualifier]
- supply and distribution [MeSH Qualifier]
- therapeutic use [MeSH Qualifier]
- toxicity [MeSH Qualifier]
- urine [MeSH Qualifier]
Automatic exact mappings (from CISMeF team)
- Dihydrofolate Reductase Inhibitor [NCIt concept]
- Dihydrofolate reductase inhibitor (disposition) [SNOMED CT concept]
- Folic acid antagonist [ICHI extension code]
- Substance with dihydrofolate reductase inhibitor mechanism of action (substance) [SNOMED CT concept]
Currated CISMeF NLP mapping
- Antifolate (substance) [SNOMED CT concept]
- Folate Antagonist [NCIt concept]
- Folic acid antagonist [ICD-11 Extension code]
- Product containing antifolate (product) [SNOMED CT concept]
Indexing information
- 10-propargyl-10-deazaaminopterin [MeSH Supplementary Concept]
- 2,4-diamino-6-(2-(5-carboxypent-1-yn-1-yl)-5-methoxybenzyl)-5-methylpyrido(2,3-d)pyrimidine [MeSH Supplementary Concept]
- bastadin 14 [MeSH Supplementary Concept]
MeSH Descriptor(s) used for indexing
- folic acid [MeSH Descriptor]
- tetrahydrofolate dehydrogenase [MeSH Descriptor]
Record concept(s)
- Folic Acid Metabolism Inhibitors [MeSH concept]
- folic acid antagonists [MeSH concept]
Semantic type(s)
- Pharmacologic Substance [UMLS semantic type]
Substance(s)
- (N-(4-amino-4-deoxy-N(10)-methylpteroyl)amino)-3-chloro-4,5-dihydro-5-isoxazoleacetic acid [MeSH Supplementary Concept]
- 10-deazaaminopterin [MeSH Supplementary Concept]
- 1843U89 [MeSH Supplementary Concept]
- 2'-fluoroaminopterin [MeSH Supplementary Concept]
- 2,4-diamino-5,6,7,8-tetrahydro-7-(4'-benzoylglutamic acid)pyrido(4',3'-4,5)furo(2,3-d)pyrimidine [MeSH Supplementary Concept]
- 2,4-diamino-5,6-dihydro-6,6-dimethyl-5-(4'-methoxyphenyl)-s-triazine [MeSH Supplementary Concept]
- 2,4-diamino-5-((3,5-dichloro-4-(1-pyrrolo)anilino)methyl)-6-bromothieno(2,3-d)pyrimidine [MeSH Supplementary Concept]
- 2,4-diamino-5-(2'-(4-carboxyphenyl)ethynyl)-5'-(methoxybenzyl)pyrimidine [MeSH Supplementary Concept]
- 2,4-diamino-5-(3-(3-(2-(acetyloxy)ethyl)-3-benzyltriazen-1-yl)-4-chlorophenyl)-6-ethylpyrimidine [MeSH Supplementary Concept]
- 2,4-diamino-5-(4-fluoro-3-nitrophenyl)-6-ethylpyrimidine [MeSH Supplementary Concept]
- 2,4-diamino-5-adamantyl-6-methylpyrimidine [MeSH Supplementary Concept]
- 2,4-diamino-5-methyl-6-(2',5'-dimethoxyphenylthio)pyrrolo(2,3-d)pyrimidine [MeSH Supplementary Concept]
- 2,4-diamino-6-((2',5'-dichloroanilino)methyl)pyrido(2,3-d)pyrimidine [MeSH Supplementary Concept]
- 2,4-diamino-6-((3',4',5'-trichloroanilino)methyl)pyrido(2,3-d)pyrimidine [MeSH Supplementary Concept]
- 2,4-diamino-6-((3',4',5'-trimethoxy-N-methylanilino)methyl)pyrido(3,2-d)pyrimidine [MeSH Supplementary Concept]
- 2,4-diamino-6-(2'-O-(3-carboxypropyl)oxydibenz(b,f)azepin-5-yl)methylpteridine [MeSH Supplementary Concept]
- 2,4-diamino-6-(N-(2',5'-dimethoxybenzyl)-N-methylamino)pyrido(2,3-d)pyrimidine [MeSH Supplementary Concept]
- 3',5'-dichloromethotrexate [MeSH Supplementary Concept]
- 3'-fluoroaminopterin [MeSH Supplementary Concept]
- 3-azidopyrimethamine [MeSH Supplementary Concept]
- 4,6-diamino-1,2-dihydro-2,2-dimethyl-1-(4-phenylthiomethylphenyl)-1,3,5-triazine [MeSH Supplementary Concept]
- 5-deazaaminopterin [MeSH Supplementary Concept]
- 5-deazafolic acid [MeSH Supplementary Concept]
- 5-deazamethotrexate [MeSH Supplementary Concept]
- 7-hydroxymethotrexate [MeSH Supplementary Concept]
- BRL 6231 [MeSH Supplementary Concept]
- BW 1540 [MeSH Supplementary Concept]
- BW 2315 [MeSH Supplementary Concept]
- CB 3717 [MeSH Supplementary Concept]
- ICI 198583 [MeSH Supplementary Concept]
- M&B 35769 [MeSH Supplementary Concept]
- N-((2,4-diaminopteridin-6-yl)methyl)dibenz(b,f)azepine [MeSH Supplementary Concept]
- N-((5-(2,4-diamino-6-pteridinyl)ethyl)-2-thenoyl)glutamic acid [MeSH Supplementary Concept]
- N-(2-amino-4-ethyl((pyrrolo(2,3-d)pyrimidin-5-yl)ethyl)benzoyl)glutamic acid [MeSH Supplementary Concept]
- N-(2-amino-4-ethyl-6-methyl((pyrrolo(2,3-d)pyrimidin-5-yl)ethyl)benzoyl)glutamic acid [MeSH Supplementary Concept]
- N-(4-((2,4-diamino-5-methyl-4,7-dihydro-3H-pyrrolo(2,3-d)pyrimidin-6-yl)thio)benzoyl)glutamic acid [MeSH Supplementary Concept]
- N-(4-((2,4-diaminoquinazoline-6-yl)methylene)oxycarbonyl)benzoyl glutamic acid [MeSH Supplementary Concept]
- N-(4-((2-amino-4-oxo-5-methyl-4,7-dihydro-3H-pyrrolo(2,3-d)pyrimidin-6-yl)thio)benzoyl)glutamic acid [MeSH Supplementary Concept]
- Pemetrexed [MeSH Descriptor]
- aditoprim [MeSH Supplementary Concept]
- aminopterin [MeSH Descriptor]
- brodimoprim [MeSH Supplementary Concept]
- cycloguanil [MeSH Supplementary Concept]
- dapsone [MeSH Descriptor]
- edatrexate [MeSH Supplementary Concept]
- ethylbenzoprim [MeSH Supplementary Concept]
- gamma-methylene-10-deazaaminopterin [MeSH Supplementary Concept]
- gamma-methylene-10-ethyl-10-deazaaminopterin [MeSH Supplementary Concept]
- iclaprim [MeSH Supplementary Concept]
- lometrexol [MeSH Supplementary Concept]
- lysine-iodoacetylmethotrexate [MeSH Supplementary Concept]
- methotrexate [MeSH Descriptor]
- methylbenzoprim [MeSH Supplementary Concept]
- metoprine [MeSH Supplementary Concept]
- nolatrexed [MeSH Supplementary Concept]
- piritrexim [MeSH Supplementary Concept]
- pyrimethamine [MeSH Descriptor]
- raltitrexed [MeSH Supplementary Concept]
- triazinate [MeSH Supplementary Concept]
- trimethoprim [MeSH Descriptor]
- trimetrexate [MeSH Descriptor]
UMLS correspondences (same concept)
- Antifolate (substance) [SNOMED CT concept]
- Folate Antagonist [NCIt concept]
- Folic acid antagonist [ICD-11 Extension code]
- Product containing antifolate (product) [SNOMED CT concept]

Keyword's position in hierarchy(ies) :

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