Dihydrofolate Reductase Inhibitor

Preferred Label : Dihydrofolate Reductase Inhibitor;

NCIt synonyms : DHFR Inhibitor;

NCIt definition : Any substance that inhibits dihydrofolate reductase, an enzyme that catalyzes the conversion of dihydrofolate to tetrahydrofolate, an essential reaction for de novo glycine and purine synthesis. Inhibition of dihydrofolate reductase interferes with DNA and protein synthesis.;

Details

Origin ID

C2153;

UMLS CUI

C2911817;

Automatic exact mappings (from CISMeF team)
- Dihydrofolate reductase inhibitor (disposition) [SNOMED CT concept]
- Substance with dihydrofolate reductase inhibitor mechanism of action (substance) [SNOMED CT concept]
- folic acid antagonists [MeSH Descriptor]
Semantic type(s)
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Substance with dihydrofolate reductase inhibitor mechanism of action (substance) [SNOMED CT concept]

Keyword's position in hierarchy(ies) :

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