trimetrexate - CISMeF

Preferred Label : trimetrexate;

MeSH definition : A nonclassical folic acid inhibitor through its inhibition of the enzyme dihydrofolate reductase. It is being tested for efficacy as an antineoplastic agent and as an antiparasitic agent against PNEUMOCYSTIS PNEUMONIA in AIDS patients. Myelosuppression is its dose-limiting toxic effect.;

CISMeF synonym : trimetrexate ipsen brand; ipsen brand of trimetrexate;

MeSH hyponym : JB-11; trimetrexate hydrate; trimetrexate monohydrate, monoacetate; NSC-328564; NSC-249008; CI-898; JB 11; JB11; Monohydrate, Monoacetate Trimetrexate; NSC 328564; NSC328564; Hydrate, Trimetrexate; CI 898; CI898; NSC 249008; NSC249008;

MeSH CAS label : 2,4-Quinazolinediamine, 5-methyl-6-(((3,4,5-trimethoxyphenyl)amino)methyl)-;

MeSH Related Number : trimetrexate monohydrate, monoacetate; trimetrexate hydrate; 117381-09-6 (monohydrate, monoacetate); 117381-10-9 (hydrate); 52128-35-5 (Trimetrexate);

Registry Number MeSH : 52128-35-5;

Related CAS MeSH : 117381-09-6 (Trimetrexate monohydrate, monoacetate); 117381-10-9 (Trimetrexate hydrate);

Is substance : O;

UNII : UPN4ITI8T4;

InChIKey : NOYPYLRCIDNJJB-UHFFFAOYSA-N;

Details

Origin ID

D016597;

UMLS CUI

C0085176;

ATC code(s)
- trimetrexate [ATC Code]
ATC code(s)
- trimetrexate [ATC Code]
Allowable qualifiers
- administration and dosage [MeSH Qualifier]
- adverse effects [MeSH Qualifier]
- agonists [MeSH Qualifier]
- analogs and derivatives [MeSH Qualifier]
- analysis [MeSH Qualifier]
- antagonists and inhibitors [MeSH Qualifier]
- blood [MeSH Qualifier]
- cerebrospinal fluid [MeSH Qualifier]
- chemical synthesis [MeSH Qualifier]
- chemistry [MeSH Qualifier]
- classification [MeSH Qualifier]
- contraindications [MeSH Qualifier]
- economics [MeSH Qualifier]
- history [MeSH Qualifier]
- immunology [MeSH Qualifier]
- isolation and purification [MeSH Qualifier]
- metabolism [MeSH Qualifier]
- pharmacokinetics [MeSH Qualifier]
- pharmacology [MeSH Qualifier]
- poisoning [MeSH Qualifier]
- radiation effects [MeSH Qualifier]
- standards [MeSH Qualifier]
- supply and distribution [MeSH Qualifier]
- therapeutic use [MeSH Qualifier]
- toxicity [MeSH Qualifier]
- urine [MeSH Qualifier]
Currated CISMeF NLP mapping
- Product containing trimetrexate (medicinal product) [SNOMED CT concept]
- Trimetrexate [ICD-11 Extension code]
- Trimetrexate [NCIt concept]
- Trimetrexate (substance) [SNOMED CT concept]
- trimetrexate [SNOMED Notion]
Pharmacological action(s)
- antifungal agents [MeSH Descriptor]
- antimetabolites, antineoplastic [MeSH Descriptor]
- folic acid antagonists [MeSH Descriptor]
Record concept(s)
- CI-898 [MeSH concept]
- JB-11 [MeSH concept]
- NSC-249008 [MeSH concept]
- NSC-328564 [MeSH concept]
- trimetrexate [MeSH concept]
- trimetrexate hydrate [MeSH concept]
- trimetrexate monohydrate, monoacetate [MeSH concept]
Related MeSH Supplementary Concept(s)
- trimetrexate glucuronate [MeSH Supplementary Concept]
See also inter- (CISMeF)
- toxic accident due to trimetrexate [Indication]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Product containing trimetrexate (medicinal product) [SNOMED CT concept]
- Trimetrexate [ICD-11 Extension code]
- Trimetrexate [NCIt concept]
- Trimetrexate (substance) [SNOMED CT concept]
- trimetrexate [ATC Code]
- trimetrexate [SNOMED Notion]
Validated automatic mappings to BTNT
- trimetrexate [ATC Code]

Keyword's position in hierarchy(ies) :

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