" /> Trimetrexate - CISMeF





Preferred Label : Trimetrexate;

NCIt synonyms : Trimexate; 5-Methyl-6-[[(3,4,5-trimethoxyphenyl)amino]methyl]-2,4-quinazolinediamine; TMQ;

NCIt related terms : 2,4-Quinazolinediamine, 5-methyl-6-[[(3,4,5-trimethoxyphenyl)amino]methyl]-;

NCIt definition : A methotrexate derivative with potential antineoplastic activity. Trimetrexate inhibits the enzyme dihydrofolate reductase, thereby preventing the synthesis of purine nucleotides and thymidylate, with subsequent inhibition of DNA and RNA synthesis. Trimetrexate also exhibits antiviral activity. (NCI04);

UNII : UPN4ITI8T4;

InChIKey : NOYPYLRCIDNJJB-UHFFFAOYSA-N;

CAS number : 52128-35-5;

Molecule name : CI-898;

Chemical formula : C19H23N5O3;

NSC code : 249008;

Codes from synonyms : NSC0249008; NSC0352122; 18846;

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Keyword's position in hierarchy(ies) : arborescence

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07/05/2025


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