" /> Trimetrexate Glucuronate - CISMeF





Preferred Label : Trimetrexate Glucuronate;

NCIt synonyms : 2,4-Diamino-5-methyl-6-[(3,4,5-trimethoxyanilino)methyl]quinazoline mono-D-glucuronate; TMTX;

NCIt definition : A lipid soluble methotrexate derivative with potential antineoplastic activity. Trimetrexate glucuronate inhibits the enzyme dihydrofolate reductase, thereby preventing the synthesis of purine nucleotides and thymidylate, with subsequent inhibition of DNA and RNA synthesis. Trimetrexate glucuronate also exhibits antiviral activity. (NCI04);

Alternative definition : NCI-GLOSS: A drug that belongs to the family of drugs called antimetabolites. It is used in the treatment of pneumocystis carinii pneumonia and is being studied in the treatment of cancer.;

UNII : L137U4A79K;

InChIKey : ZCJXQWYMBJYJNB-LRDBBFHQSA-N;

CAS number : 82952-64-5; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 82952-64-5 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Drug name : Neutrexin;

Chemical formula : C19H23N5O3.C6H10O7;

NSC code : 352122;

Codes from synonyms : NSC0352122; CDR0000045259;

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15/05/2024


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