Trimetrexate Glucuronate

Preferred Label : Trimetrexate Glucuronate;

NCIt synonyms : 2,4-Diamino-5-methyl-6-[(3,4,5-trimethoxyanilino)methyl]quinazoline mono-D-glucuronate; TMTX;

NCIt definition : A lipid soluble methotrexate derivative with potential antineoplastic activity. Trimetrexate glucuronate inhibits the enzyme dihydrofolate reductase, thereby preventing the synthesis of purine nucleotides and thymidylate, with subsequent inhibition of DNA and RNA synthesis. Trimetrexate glucuronate also exhibits antiviral activity. (NCI04);

Alternative definition : NCI-GLOSS: A drug that belongs to the family of drugs called antimetabolites. It is used in the treatment of pneumocystis carinii pneumonia and is being studied in the treatment of cancer.;

UNII : L137U4A79K;

InChIKey : ZCJXQWYMBJYJNB-LRDBBFHQSA-N;

CAS number : 82952-64-5;

Drug name : Neutrexin;

Chemical formula : C19H23N5O3.C6H10O7;

NSC code : 352122;

Codes from synonyms : NSC0352122; CDR0000045259;

Details

Origin ID

C1265;

UMLS CUI

C0077209;

Currated CISMeF NLP mapping
- trimetrexate glucuronate [MeSH concept]
- trimetrexate glucuronate [MeSH Supplementary Concept]
False automatic mappings
- Trimetrexate glucuronate (substance) [SNOMED CT concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Trimetrexate glucuronate (substance) [SNOMED CT concept]
- trimetrexate glucuronate [MeSH Supplementary Concept]
- trimetrexate glucuronate [MeSH concept]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_free_acid_or_base_form
- Trimetrexate [NCIt concept]
is_component_of_chemotherapy_regimen
- Cisplatin/Trimetrexate Glucuronate [NCIt concept]
- Dapsone/Trimetrexate Glucuronate [NCIt concept]
- Etoposide/Trimetrexate Glucuronate [NCIt concept]
- Fluorouracil/Leucovorin Calcium/Trimetrexate Glucuronate [NCIt concept]
- Fluorouracil/Trimetrexate Glucuronate [NCIt concept]
- Leucovorin Calcium/Trimetrexate Glucuronate [NCIt concept]
- Pentamidine/Trimetrexate Glucuronate [NCIt concept]
is_salt_form_of
- Trimetrexate [NCIt concept]

Keyword's position in hierarchy(ies) :

You can consult :

recommendations
documents concerning education
documents for patients