Preferred Label : methotrexate;

MeSH definition : An antineoplastic antimetabolite with immunosuppressant properties. It is an inhibitor of TETRAHYDROFOLATE DEHYDROGENASE and prevents the formation of tetrahydrofolate, necessary for synthesis of thymidylate, an essential component of DNA.;

MeSH synonym : amethopterin;

CISMeF synonym : 15475-56-6 (Methotrexate, sodium salt); 7413-34-5 (Methotrexate, disodium salt); disodium salt methotrexate; sodium salt methotrexate;

MeSH hyponym : methotrexate, dicesium salt; Methotrexate, (D)-Isomer; methotrexate hydrate; mexate; Methotrexate, (DL)-Isomer; methotrexate sodium; Sodium, Methotrexate; Methotrexate, Sodium Salt; Methotrexate, Disodium Salt; Hydrate, Methotrexate; Dicesium Salt Methotrexate;

MeSH CAS label : L-Glutamic acid, N-(4-(((2,4-diamino-6-pteridinyl)methyl)methylamino)benzoyl)-;

MeSH Related Number : methotrexate, (D)-Isomer; methotrexate, dicesium salt; methotrexate hydrate; methotrexate, (DL)-Isomer; 133073-73-1 (x.H2O); 15475-56-6 (Na salt); 51865-79-3 ((D)-isomer); 59-05-2 (Methotrexate); 60388-53-6 ((DL)-isomer); 86669-44-5 (di-Cs salt); methotrexate sodium; 3IG1E710ZN;

Registry Number MeSH : 59-05-2;

Related CAS MeSH : 51865-79-3 (Methotrexate, (D)-Isomer); 86669-44-5 (Methotrexate, dicesium salt); 133073-73-1 (Methotrexate hydrate); 60388-53-6 (Methotrexate, (DL)-Isomer); 3IG1E710ZN (Methotrexate sodium);

Wikipedia link : https://en.wikipedia.org/wiki/Methotrexate;

Codes EINECS : 200-413-8;

Is substance : O;

UNII : YL5FZ2Y5U1;

InChIKey : FBOZXECLQNJBKD-ZDUSSCGKSA-N;

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An antineoplastic antimetabolite with immunosuppressant properties. It is an inhibitor of TETRAHYDROFOLATE DEHYDROGENASE and prevents the formation of tetrahydrofolate, necessary for synthesis of thymidylate, an essential component of DNA.

https://minerva-ebp.be/Theme/Analysis/901
2025
Belgium
critical appraisal or critical reading
hand
methotrexate
osteoarthritis
degenerative joint disease of hand
methotrexate

---
https://www.has-sante.fr/jcms/p_3598812/fr/nordimet-methotrexate-psoriasis-en-plaque-modere
2025
false
false
false
France
adult
insurance, health, reimbursement
treatment outcome
injections, subcutaneous
methotrexate
evaluation of the transparency committee
psoriasis
methotrexate

---
https://ansm.sante.fr/actualites/medicaments-a-base-de-methotrexate-par-voie-orale-imeth-novatrex-et-generiques-une-carte-patients-et-une-brochure-professionnels-de-sante-pour-eviter-les-surdosages
2025
false
false
false
France
French
risk management
risk
methotrexate
poisoning
pharmacovigilance note
guideline
patients guideline

---
https://www.rheuma-net.ch/fr/doc/methotrexat-1/viewdocument/352
2024
Switzerland
guideline
methotrexate
Methotrexate
methotrexate
Background Treatment

---
https://ansm.sante.fr/tableau-marr/methotrexate-per-os
2024
false
false
false
France
French
guidelines for drug use
risk management
methotrexate
administration, oral
patient education handout
medication errors

---
https://ansm.sante.fr/actualites/fortes-tensions-dapprovisionnement-en-methotrexate-injectable-1g-et-5g-des-alternatives-pour-pallier-la-rupture
2024
false
false
false
France
French
drug information
methotrexate
injections
Product containing methotrexate in parenteral dose form (medicinal product form)
continuity of patient care
france
methotrexate

---
https://www.cochrane.org/fr/CD003129/MUSKEL_quels-sont-les-benefices-et-les-risques-du-methotrexate-dans-le-traitement-de-larthrite-juvenile
2024
false
true
false
United Kingdom
France
treatment outcome
review of literature
french abstract
arthritis, juvenile
methotrexate

---
https://ansm.sante.fr/tableau-acces-derogatoire/methotrexate
2024
false
false
false
France
French
methotrexate
guidelines for drug use
pregnancy, ectopic
administration, oral
pharmaceutical solutions
injections
arthritis, juvenile
uveitis, anterior
drug information
precursor cell lymphoblastic Leukemia-Lymphoma

---
https://ansm.sante.fr/actualites/decision-du-27-06-2024-modification-du-cadre-de-prescription-compassionnelle-des-medicaments-a-base-de-methotrexate-solution-injectable-dans-le-traitement-medical-de-la-grossesse-extra-uterine-geu
2024
false
false
false
France
French
legislation
drug information
pregnancy, ectopic
methotrexate
contraception

---
https://www.has-sante.fr/jcms/p_3434166/fr/methotrexate-orion-methotrexate-polyarthrite-rhumatoide-psoriasis-rhumatisme-psoriasique-et-leucemie-aigue-lymphoblastique
2023
false
false
false
France
psoriasis
treatment outcome
insurance, health, reimbursement
administration, oral
methotrexate
precursor cell lymphoblastic Leukemia-Lymphoma
Acute Lymphoblastic Leukemia
dermatologic agents
antirheumatic agents
antimetabolites, antineoplastic
evaluation of the transparency committee
arthritis, rheumatoid
methotrexate
arthritis, psoriatic

---
https://www.cancer.fr/catalogue-des-publications/mesures-de-prevention-et-de-gestion-de-la-toxicite-renale-induite-par-le-methotrexate-haute-dose-avis-d-experts
2023
false
false
false
France
Toxicity renal
acute kidney injury
risk factors
drug interactions
leucovorin
guideline
methotrexate

---
https://ansm.sante.fr/disponibilites-des-produits-de-sante/medicaments/imeth-2-5-mg-et-10-mg-comprime-methotrexate
2023
false
false
false
France
French
methotrexate
administration, oral
drug information

---
https://www.has-sante.fr/jcms/p_3382729/fr/metotab-methotrexate
2022
false
false
false
France
administration, oral
treatment outcome
insurance, health, reimbursement
drugs, generic
Product containing precisely methotrexate 10 milligram/1 each conventional release oral tablet (clinical drug)
Product containing precisely methotrexate 2.5 milligram/1 each conventional release oral tablet (clinical drug)
arthritis, rheumatoid
arthritis, psoriatic
psoriasis
precursor cell lymphoblastic Leukemia-Lymphoma
methotrexate
dermatologic agents
antirheumatic agents
antimetabolites, antineoplastic
evaluation of the transparency committee
methotrexate

---
https://www.has-sante.fr/jcms/p_3358603/fr/nordimet-methotrexate-maladie-de-crohn
2022
false
false
false
France
insurance, health, reimbursement
treatment outcome
methotrexate
injections, subcutaneous
crohn disease
remission induction
adult
methotrexate
evaluation of the transparency committee

---
https://www.has-sante.fr/jcms/p_3358600/fr/imeth-methotrexate-disodique-maladie-de-crohn
2022
false
false
false
France
treatment outcome
insurance, health, reimbursement
injections, subcutaneous
methotrexate
immunosuppressive agents
adult
evaluation of the transparency committee
crohn disease
methotrexate

---
https://ansm.sante.fr/actualites/decision-du-16-05-2022-modification-du-cadre-de-prescription-compassionnelle-des-medicaments-a-base-de-methotrexate-solution-injectable-dans-le-traitement-medical-de-la-grossesse-extra-uterine-geu
2022
false
false
false
false
France
French
legislation
drug information
methotrexate

---
https://www.has-sante.fr/jcms/p_3317076/fr/izixate-methotrexate-polyarthrite-rhumatoide
2022
false
false
false
France
injections, subcutaneous
treatment outcome
insurance, health, reimbursement
antirheumatic agents
arthritis, juvenile
crohn disease
arthritis, psoriatic
psoriasis
immunosuppressive agents
dermatologic agents
methotrexate
evaluation of the transparency committee
methotrexate
arthritis, rheumatoid

---
https://www.has-sante.fr/jcms/p_3315488/fr/methotrexate-orion-methotrexate-disodique
2022
false
false
false
France
evaluation of the transparency committee
methotrexate
methotrexate

---
https://www.has-sante.fr/jcms/p_3314510/fr/novatrex-2-5-mg-methotrexate
2022
false
false
false
France
methotrexate
insurance, health, reimbursement
precursor cell lymphoblastic Leukemia-Lymphoma
adult
child
adolescent
treatment outcome
administration, oral
Maintenance therapy (procedure)
evaluation of the transparency committee

---
https://ansm.sante.fr/informations-de-securite/methotrexate-haute-dose-mtx-hd-lansm-rappelle-les-mesures-generales-de-prevention-du-risque-de-nephrotoxicite
2022
false
false
false
France
French
pharmacovigilance note
guidelines for drug use
methotrexate
High-Dose Methotrexate Regimen
methotrexate
antimetabolites, antineoplastic
antimetabolites, antineoplastic
hematologic neoplasms
osteosarcoma
risk
acute kidney injury
renal insufficiency, acute
Methotrexate overdose (disorder)
kidney function tests
adult
aged
risk management
drug interactions
continuity of patient care
methotrexate
methotrexate
methotrexate
poisoning
poisoning
leucovorin
glucarpidase

---
https://ansm.sante.fr/actualites/medicaments-a-base-de-methotrexate-par-voie-orale-imeth-novatrex-et-generiques-une-carte-patients-et-une-brochure-professionnels-de-sante-pour-eviter-les-surdosages
2022
false
false
false
France
French
methotrexate
administration, oral
Methotrexate overdose (disorder)
drug overdose
pharmacovigilance note
patients guideline
guideline
drug interactions
risk management
methotrexate

---
https://dumas.ccsd.cnrs.fr/dumas-04255693
2022
France
dissertations, academic
Treatment
Therapeutic
review literature as topic
rheumatic diseases
rheumatic fever
patient status observation, nos
Satisfaction
Methotrexate
Chronic Graft Versus Host Disease
acquaintance
methotrexate
Patient Observation
Reviewing
patient compliance
methotrexate
insight, nos
Therapeutic Procedure
disease
Rheumatologic Disorder
patient satisfaction
knowledge
rheumatism, nos

---
https://www.cbip.be/fr/articles/3696?folia=3691
2021
false
false
false
Belgium
French
journal article
arthritis, rheumatoid
methotrexate
Drug-Related side effects and adverse reactions
folic acid
Methotrexate adverse reaction (disorder)

---
https://pharmactuel.com/index.php/pharmactuel/article/view/1318
https://pharmactuel.com/index.php/pharmactuel/article/view/1318/1247
2020
false
false
false
Canada
atherosclerosis
administration, oral
Atherosclerotic Cardiovascular Disease
cardiovascular diseases
double-blind method
follow-up studies
treatment outcome
critical appraisal or critical reading
methotrexate

---
https://www.has-sante.fr/jcms/p_3202298/fr/methotrexate
2020
false
false
false
France
guidelines for drug use
pregnancy, ectopic
insurance, health, reimbursement
abortifacient agents, nonsteroidal
continuity of patient care
chorionic gonadotropin
methotrexate
abortifacient agents, nonsteroidal
injections
evaluation of the transparency committee
methotrexate

---
https://dumas.ccsd.cnrs.fr/dumas-02933010
2020
France
dissertations, academic
education
addiction, nos
housing
adaptation, nos
aged, 80 and over
homebound persons
rehabilitation
MIME protocol
habilitation
elderly person, nos
aged
aged, 80 and over
aged
antineoplastic combined chemotherapy protocols
etoposide
ifosfamide
methotrexate
mitoguazone

---
https://www.getaid.org/wp-content/uploads/2020/03/InformationISCovid10mars.pdf
2020
France
coronavirus infections
COVID-19
popular works
azathioprine
rheumatology
disease
adrenal cortical hormone, nos
glucocorticoids
methotrexate
Diseases
Janus Kinase Inhibitors
intestinal diseases
Dermatology
Dermatologists
disease, nos
disease of intestine, nos
methotrexate
dermatology
immunosuppressive agents
azathioprine
biological therapy
corticosteroid therapy
Dermatology
disease
pneumonia, viral
COVID-19

---
https://www.omedit-centre.fr/medias/Methotrexate-oral-securiser-rythme-administration.pdf
2020
France
scientific and technical information
methotrexate
administration, oral
methotrexate
oral route

---
https://www.has-sante.fr/jcms/p_3151141/fr/methotrexate-accord
2020
false
false
false
France
drugs, generic
administration, oral
methotrexate
evaluation of the transparency committee
methotrexate
methotrexate

---
https://www.has-sante.fr/jcms/p_3219449/fr/methotrexate-accord
2020
false
false
false
France
insurance, health, reimbursement
treatment outcome
crohn disease
drug therapy, combination
adult
methotrexate
injections, subcutaneous
immunosuppressive agents
evaluation of the transparency committee
methotrexate

---
https://www.has-sante.fr/jcms/p_3159947/fr/metoject
2020
false
false
false
France
methotrexate
treatment outcome
insurance, health, reimbursement
psoriasis
injections
dermatologic agents
methotrexate
evaluation of the transparency committee

---
https://ansm.sante.fr/informations-de-securite/medicaments-a-base-de-methotrexate-recommandations-visant-a-eviter-les-erreurs-de-prise-potentiellement-fatales-lors-de-lutilisation-du-methotrexate-dans-le-traitement-des-maladies-inflammatoires
2020
false
false
false
France
French
methotrexate
pharmacovigilance note
medication errors
methotrexate
arthritis, rheumatoid
psoriasis
crohn disease
methotrexate

---
https://hiboot.larhumatologie.fr/
https://apps.apple.com/fr/app/hiboot/id1188410178?mt=8
https://play.google.com/store/apps/details?id=com.hiboot
2019
false
true
false
false
France
French
mobile application
methotrexate
biological therapy
mobile applications
rheumatic fever

---
https://www.has-sante.fr/jcms/p_3121601/fr/metoject
2019
false
false
false
France
methotrexate
methotrexate
adult
crohn disease
treatment outcome
insurance, health, reimbursement
injections
evaluation of the transparency committee

---
https://www.has-sante.fr/portail/jcms/c_2824467/fr/methotrexate-accord
2018
false
false
false
false
France
French
evaluation of the transparency committee
methotrexate
methotrexate

---
https://www.has-sante.fr/portail/jcms/c_2896738/en/metoject
2018
false
true
false
France
methotrexate
treatment outcome
insurance, health, reimbursement
injections
antirheumatic agents
dermatologic agents
arthritis, rheumatoid
arthritis, psoriatic
psoriasis
arthritis, juvenile
methotrexate
evaluation of the transparency committee

---
https://www.has-sante.fr/portail/jcms/c_2824798/fr/methotrexate-accord
2018
false
false
false
false
France
French
evaluation of the transparency committee
methotrexate
methotrexate

---
https://www.has-sante.fr/portail/jcms/c_2820671/fr/imeth
2018
false
France
French
Prefilled Syringe Dosage Form
injections, subcutaneous
injections, intramuscular
crohn disease
methotrexate
adult
insurance, health, reimbursement
methotrexate
evaluation of the transparency committee

---
https://www.has-sante.fr/portail/jcms/c_2870213/fr/prexate
2018
false
false
false
false
France
French
evaluation of the transparency committee
treatment outcome
arthritis, rheumatoid
psoriasis
arthritis, juvenile
methotrexate
antirheumatic agents
dermatologic agents
methotrexate
immunosuppressive agents
injections, subcutaneous
arthritis, psoriatic

---
http://www.sudoc.fr/231756380
2018
France
dissertations, academic
bullous pemphigoid
Bullous pemphigoid
data collection
pemphigoid, bullous
methotrexate
methotrexate
tolerance, nos

---
https://www.ema.europa.eu/medicines/human/EPAR/Jylamvo
2017
false
false
false
United Kingdom
French
English
treatment outcome
syndication feed
summary of product characteristics
package leaflet
drug evaluation
methotrexate
antirheumatic agents
antirheumatic agents
dermatologic agents
dermatologic agents
psoriasis
arthritis, psoriatic
drug approval
europe
drug interactions
pregnancy
breast feeding
arthritis, rheumatoid
arthritis, juvenile
adult
adolescent
risk assessment
child
drug evaluation, preclinical
administration, oral
precursor cell lymphoblastic Leukemia-Lymphoma
antimetabolites, antineoplastic
antimetabolites, antineoplastic
methotrexate

---
Methotrexate: Serious dosing errors
https://www.hc-sc.gc.ca/dhp-mps/medeff/bulletin/hpiw-ivps_2017-01-page3-fra.php#mae
2017
false
false
false
Canada
French
English
journal article
pharmacovigilance note
medication errors
methotrexate
methotrexate
methotrexate
antimetabolites, antineoplastic
antirheumatic agents
dermatologic agents
administration, oral
Incorrect dose administered
canada

---
http://www.has-sante.fr/portail/jcms/c_2756583/fr/zawek
2017
false
false
false
France
French
evaluation of the transparency committee
methotrexate
injections

---
http://www.has-sante.fr/portail/jcms/c_2744490/fr/novatrex
2017
false
false
false
France
French
evaluation of the transparency committee
insurance, health, reimbursement
methotrexate
methotrexate

---
Summary Safety Review - Levetiracetam and Methotrexate - Assessing the Potential Risk of Drug-Drug Interaction
https://www.hc-sc.gc.ca/dhp-mps/medeff/reviews-examens/levetiracetam-fra.php
2016
false
false
false
Canada
French
English
drug interactions
risk assessment
methotrexate
pharmacovigilance note
methotrexate
levetiracetam
levetiracetam
methotrexate
canada
renal insufficiency, acute
levetiracetam
methotrexate
methotrexate
product surveillance, postmarketing
acute kidney injury
Levetiracetam
Levetiracetam

---
http://www.has-sante.fr/portail/jcms/c_2730809/fr/nordimet
2016
false
false
false
France
French
evaluation of the transparency committee
injections, subcutaneous
antirheumatic agents
dermatologic agents
methotrexate
methotrexate
arthritis, rheumatoid
psoriasis
arthritis, juvenile
arthritis, psoriatic
treatment outcome
insurance, health, reimbursement

---
http://www.cri-net.com/fiches-pratiques-et-recommandations/fiches-pratiques-mtx
2016
false
false
false
France
French
methotrexate
methotrexate
patient care management
Off-Label use
guidelines for drug use
practice guideline
consensus
methotrexate
administration, oral
injections, subcutaneous
arthritis, rheumatoid
continuity of patient care
immunosuppressive agents
immunosuppressive agents
antirheumatic agents
antirheumatic agents
pregnancy
vaccination
renal insufficiency
dialysis
surgical procedures, operative
adult
child
arthritis, juvenile
arthritis, psoriatic
psoriasis
spondylarthropathies
uveitis
juvenile-onset scleroderma
splenectomy
patients guideline
scleroderma, localized
scleroderma, systemic
dermatomyositis

---
https://www.ema.europa.eu/medicines/human/EPAR/Nordimet
2016
false
false
false
United Kingdom
French
English
treatment outcome
syndication feed
summary of product characteristics
package leaflet
drug evaluation
methotrexate
antirheumatic agents
antirheumatic agents
dermatologic agents
dermatologic agents
psoriasis
arthritis, psoriatic
drug approval
europe
drug interactions
pregnancy
breast feeding
arthritis, rheumatoid
arthritis, juvenile
adult
adolescent
injections, subcutaneous
risk assessment
Pre-filled Pen Syringe
child
drug evaluation, preclinical
methotrexate

---
http://www.sudoc.fr/203615735
2016
false
false
false
France
French
dissertations, academic
treaties
arthritis, rheumatoid
prescription, nos
methotrexate
initial
review literature
biological therapy
data collection
association
Polyarthritis
guideline adherence
review literature as topic
combined modality therapy
Off-Label use
methotrexate
recommendations, health planning
review
has patient
patients
international cooperation
review
evaluation studies as topic
association
health planning guidelines

---
http://www.has-sante.fr/portail/jcms/c_2678865/fr/novatrex
2016
false
France
French
administration, oral
methotrexate
adult
insurance, health, reimbursement
psoriasis
dermatologic agents
arthritis, rheumatoid
antirheumatic agents
methotrexate
evaluation of the transparency committee

---
http://www.sfdermato.org/media/pdf/fmc/fmc-fevrier-0c7b79830b304e0e1698b2ccab3636cc.pdf
http://dx.doi.org/10.1016/j.annder.2015.09.005
2016
false
false
false
France
French
journal article
child
methotrexate
methotrexate
continuity of patient care
methotrexate
dermatologic agents
dermatologic agents
psoriasis
dermatitis, atopic
alopecia areata
juvenile linear scleroderma
injections
administration, oral
practice guidelines as topic
scleroderma, localized

---
http://www.has-sante.fr/portail/jcms/c_2620156/fr/metoject
2016
false
France
French
evaluation of the transparency committee
Pre-filled Pen Syringe
Injectable Solution Dosage Form
methotrexate
methotrexate
injections
insurance, health, reimbursement
adult
arthritis, rheumatoid
antirheumatic agents
dermatologic agents
arthritis, juvenile
psoriasis
arthritis, psoriatic
adolescent
child

---
http://www.has-sante.fr/portail/jcms/c_2625120/fr/methotrexate-biodim-ledertrexate
2016
false
France
French
small cell lung carcinoma
ovarian neoplasms
Ovarian Adenocarcinoma
trophoblastic tumor, placental site
Breast Adenocarcinoma
breast neoplasms
urinary bladder neoplasms
Bladder Carcinoma
precursor cell lymphoblastic Leukemia-Lymphoma
lymphoma, Non-Hodgkin
osteosarcoma
upper aerodigestive tract neoplasms
meningeal neoplasms
methotrexate
injections
antirheumatic agents
dermatologic agents
insurance, health, reimbursement
adult
adolescent
arthritis, rheumatoid
arthritis, psoriatic
arthritis, juvenile
psoriasis
treatment outcome
evaluation of the transparency committee
head and neck neoplasms

---
http://www.jogc.com/article/S1701-2163(16)39086-7/abstract
10.1016/j.jogc.2016.04.001
2016
false
false
true
Canada
French
practice guideline
abortion, induced
abortion, induced
methotrexate
misoprostol
abortion, induced
abortifacient agents
gestational age
pregnancy
Contraindications, Procedure

---
http://www.has-sante.fr/portail/jcms/c_2563033/fr/imeth
2015
false
France
French
arthritis, psoriatic
Prefilled Syringe Dosage Form
injections, subcutaneous
injections, intramuscular
arthritis, juvenile
methotrexate
adult
insurance, health, reimbursement
psoriasis
dermatologic agents
arthritis, rheumatoid
antirheumatic agents
methotrexate
evaluation of the transparency committee

---
http://www.has-sante.fr/portail/jcms/c_2031566/fr/imeth
2015
false
France
French
drugs, generic
administration, oral
tablets
methotrexate
adult
insurance, health, reimbursement
psoriasis
dermatologic agents
arthritis, rheumatoid
antirheumatic agents
methotrexate
evaluation of the transparency committee

---
http://anocef.org/download.php?modele=anocef_referentiel_meta_meningees
2014
false
false
true
France
French
meningeal neoplasms
practice guideline
meningeal neoplasms
meningeal neoplasms
meningeal neoplasms
breast neoplasms
meningeal neoplasms
antineoplastic agents
molecular targeted therapy
lung neoplasms
melanoma
algorithms
methotrexate
injections, spinal
adult

---
http://www.cochrane.org/fr/CD010280/comparaison-du-mycophenolate-mofetil-et-du-methotrexate-pour-la-prevention-de-la-reaction-du-greffon-contre-lhote-apres-une-greffe-de-cellules-souches-hematopoietiques-allogeniques
2014
false
false
false
France
United Kingdom
French
french abstract
meta-analysis
graft vs host reaction
hematopoietic stem cell transplantation
transplantation, homologous
methotrexate
methotrexate
immunosuppressive agents
immunosuppressive agents
comparative study
mycophenolic acid
mycophenolic acid
mycophenolic acid

---
http://www.has-sante.fr/portail/jcms/c_1782539/fr/methotrexate-sandoz
2014
false
false
false
France
French
evaluation of the transparency committee
methotrexate
methotrexate

---
https://www.cochrane.org/fr/CD009211/le-role-de-la-radiotherapie-du-cerveau-rayons-x-dans-le-traitement-du-lymphome-cerebral
2014
false
false
false
France
United Kingdom
French
review of literature
Primary central nervous system lymphoma
lymphoma
central nervous system neoplasms
radiotherapy
treatment outcome
methotrexate
lymphoma
central nervous system neoplasms
antimetabolites, antineoplastic
french abstract
comparative study
radiotherapy

---
http://www.sciencedirect.com/science/article/pii/S1169833014001148
2014
false
true
false
France
French
arthritis, rheumatoid
journal article
practice guideline
algorithms
arthritis, rheumatoid
arthritis, rheumatoid
methotrexate
antirheumatic agents

---
http://medecine-pharmacie.univ-rouen.fr/jsp/saisie/liste_fichiergw.jsp?OBJET=DOCUMENT&CODE=1254493574296&LANGUE=0
http://medecine-pharmacie.univ-rouen.fr/servlet/com.univ.collaboratif.utils.LectureFichiergw?ID_FICHIER=12648
2014
false
false
false
false
France
tumor necrosis factor-alpha
recombinant fusion proteins
methotrexate
critical appraisal or critical reading
arthritis, rheumatoid
immunoglobulin G
receptors, tumor necrosis factor

---
http://www.lecrat.eu/?s=Etat+des+connaissances+sur+le+m%C3%A9thotrexate
France
drug information
pregnancy, nos
teratogens
pregnancy, high-risk
methotrexate
knowledge

---
http://www.cochrane.org/fr/CD003459
2014
false
France
United Kingdom
French
french abstract
review of literature
methotrexate
crohn disease
treatment outcome
induction chemotherapy
immunosuppressive agents
corticosteroid therapy

---
http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=FR&Expert=86904
false
true
false
France
scientific and technical information
methotrexate

---
http://www.lecrat.eu/?s=M%C3%A9thotrexate+-+exposition+paternelle
France
drug information
methotrexate
pregnancy, high-risk
teratogens
paternal exposure
pregnancy, nos

---
http://www.lecrat.eu/?s=M%C3%A9thotrexate
2013
France
French
methotrexate
pregnancy
folic acid antagonists
immunosuppressive agents
breast feeding
methotrexate
drug information

---
http://base-donnees-publique.medicaments.gouv.fr/extrait.php?specid=69991749
2013
summary of product characteristics
methotrexate
injections
syringes

---
http://base-donnees-publique.medicaments.gouv.fr/extrait.php?specid=64951170
2013
summary of product characteristics
methotrexate
syringes
injections

---
http://base-donnees-publique.medicaments.gouv.fr/extrait.php?specid=69310332
2013
summary of product characteristics
methotrexate
injections
syringes

---
http://www.pharmactuel.com/index.php/pharmactuel/article/view/919
2013
false
false
false
Canada
French
journal article
case reports
drug hypersensitivity
Allergy to methotrexate (finding)
desensitization, immunologic
methotrexate
drug hypersensitivity
osteosarcoma
methotrexate
antimetabolites, antineoplastic
infusions, intravenous
premedication
anaphylaxis

---
http://base-donnees-publique.medicaments.gouv.fr/extrait.php?specid=64768062
2013
summary of product characteristics
injections
methotrexate
syringes

---
http://www.cochrane.org/fr/CD000951
http://www.cochrane.org/fr/CD000951/acide-folique-ou-acide-folinique-pour-reduire-les-effets-secondaires-du-methotrexate-chez-les-personnes-atteintes-de-polyarthrite-rhumatoide
2013
false
true
false
United Kingdom
France
antirheumatic agents
folic acid
treatment outcome
leucovorin
vitamin B complex
review of literature
french abstract
methotrexate
arthritis, rheumatoid

---
http://www.pharmactuel.com/index.php/pharmactuel/article/view/870
false
Canada
French
journal article
lung diseases, interstitial
arthritis, rheumatoid
antirheumatic agents
methotrexate
aged
immunosuppressive agents
methotrexate
pneumonia, interstitial

---
http://base-donnees-publique.medicaments.gouv.fr/extrait.php?specid=66253794
2013
summary of product characteristics
injections
methotrexate
syringes

---
http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=FR&Expert=1908
2012
false
true
false
France
abnormalities, drug-induced
child
infant
methotrexate
Aminopterin/methotrexate embryofetopathy
scientific and technical information

---
http://agence-prd.ansm.sante.fr/php/ecodex/extrait.php?specid=60695745
2012
France
summary of product characteristics
package leaflet
methotrexate
tablets

---
http://agence-prd.ansm.sante.fr/php/ecodex/extrait.php?specid=60528543
2012
France
summary of product characteristics
package leaflet
injections
methotrexate

---
http://agence-prd.ansm.sante.fr/php/ecodex/extrait.php?specid=68199007
2012
France
summary of product characteristics
package leaflet
methotrexate
injections

---
http://agence-prd.ansm.sante.fr/php/ecodex/extrait.php?specid=65085105
2012
France
summary of product characteristics
package leaflet
methotrexate
injections

---
http://agence-prd.ansm.sante.fr/php/ecodex/extrait.php?specid=69202328
2012
France
summary of product characteristics
package leaflet
injections
methotrexate

---
http://agence-prd.ansm.sante.fr/php/ecodex/extrait.php?specid=67217445
2012
France
summary of product characteristics
package leaflet
methotrexate
injections

---
http://agence-prd.ansm.sante.fr/php/ecodex/extrait.php?specid=63529910
2012
France
summary of product characteristics
package leaflet
injections
methotrexate

---
http://agence-prd.ansm.sante.fr/php/ecodex/extrait.php?specid=69847122
2012
France
summary of product characteristics
package leaflet
injections
methotrexate

---
http://agence-prd.ansm.sante.fr/php/ecodex/extrait.php?specid=67301605
2012
France
summary of product characteristics
package leaflet
methotrexate
injections

---
http://agence-prd.ansm.sante.fr/php/ecodex/extrait.php?specid=61153021
2012
France
summary of product characteristics
package leaflet
injections
methotrexate

---
http://agence-prd.ansm.sante.fr/php/ecodex/extrait.php?specid=65946692
2012
France
summary of product characteristics
package leaflet
injections
methotrexate

---
http://agence-prd.ansm.sante.fr/php/ecodex/extrait.php?specid=65288721
2012
France
summary of product characteristics
package leaflet
injections
methotrexate

---
http://agence-prd.ansm.sante.fr/php/ecodex/extrait.php?specid=61981906
2012
France
summary of product characteristics
package leaflet
methotrexate
injections

---
http://agence-prd.ansm.sante.fr/php/ecodex/extrait.php?specid=60819417
2012
France
summary of product characteristics
package leaflet
tablets
methotrexate

---
http://agence-prd.ansm.sante.fr/php/ecodex/extrait.php?specid=61495968
2012
France
summary of product characteristics
package leaflet
tablets
methotrexate

---
http://www.cochrane.org/fr/CD006325
http://www.cochrane.org/fr/CD006325/methotrexate-dans-losteosarcome-de-haut-grade-chez-les-enfants-et-les-jeunes-adultes
2012
false
true
false
United Kingdom
France
treatment outcome
young adult
antineoplastic agents
methotrexate
antineoplastic agents
review of literature
french abstract
methotrexate
osteosarcoma
child

---
http://www.cochrane.org/fr/CD007102
2012
false
false
false
United Kingdom
France
antimetabolites, antineoplastic
methotrexate
dactinomycin
antibiotics, antineoplastic
treatment outcome
meta-analysis
french abstract
gestational trophoblastic disease

---
http://www.has-sante.fr/portail/jcms/c_1250130/metoject
http://www.has-sante.fr/portail/jcms/c_1250725/metoject-09052012-avis-ct11920
http://www.has-sante.fr/portail/jcms/c_401005/metoject-10-mg/ml
2012
false
France
French
evaluation of the transparency committee
methotrexate
methotrexate
injections
insurance, health, reimbursement
adult
arthritis, rheumatoid
antirheumatic agents
dermatologic agents
arthritis, juvenile
psoriasis
arthritis, psoriatic
adolescent
child

---
https://www.healthycanadians.gc.ca/recall-alert-rappel-avis/hc-sc/2012/15076a-fra.php
2012
Canada
English
French
drug interactions
proton pump inhibitors
methotrexate
methotrexate
pharmacovigilance note
methotrexate
methotrexate
proton pump inhibitors

---
http://www.cochrane.org/fr/CD009355
2012
France
United Kingdom
French
french abstract
review of literature
methotrexate
antineoplastic agents
lymphoma
central nervous system neoplasms
treatment outcome

---
https://www.inspq.qc.ca/toxicologie-clinique/utilisation-de-la-glucarpidase-dans-les-intoxications-au-methotrexate
2011
false
true
false
Canada
methotrexate
methotrexate
renal insufficiency
gamma-glutamyl hydrolase
journal article
methotrexate
Methotrexate toxicity
poisoning
gamma-glutamyl hydrolase

---
http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=FR&Expert=90070
2011
France
scientific and technical information
methotrexate

---
http://www.cochrane.org/fr/CD007560
2011
United Kingdom
France
French
review of literature
methotrexate
colitis, ulcerative
treatment outcome
immunosuppressive agents
french abstract

---
http://www.cochrane.org/fr/CD008872
2011
United Kingdom
France
French
meta-analysis
arthritis, psoriatic
methotrexate
anti-inflammatory agents, non-steroidal
antirheumatic agents
arthritis, rheumatoid
spondylarthritis
spondylitis, ankylosing
french abstract

---
http://www.cochrane.org/fr/CD002855
2011
false
true
false
France
United Kingdom
abortion, induced
prostaglandins
mifepristone
pregnancy
treatment outcome
methotrexate
review of literature
french abstract
pregnancy trimester, first

---
http://www.has-sante.fr/portail/upload/docs/application/pdf/2010-10/methotrexate_bellon_-_ct-_8473.pdf
http://www.has-sante.fr/portail/jcms/c_987192/methotrexate-bellon
2010
France
French
methotrexate
injections
administration, oral
methotrexate
insurance, health, reimbursement
dermatologic agents
antimetabolites, antineoplastic
antirheumatic agents
folic acid antagonists
evaluation of the transparency committee

---
https://www.revmed.ch/RMS/2010/RMS-240/Polyarthrite-rhumatoide-methotrexate-et-fibrose-pulmonaire-quelles-evidences
2010
Switzerland
French
arthritis, rheumatoid
pulmonary fibrosis
methotrexate
antirheumatic agents
journal article

---
http://www.cochrane.org/fr/CD000957
2010
United Kingdom
France
French
review of literature
arthritis, rheumatoid
methotrexate
treatment outcome
antirheumatic agents
french abstract

---
http://www.john-libbey-eurotext.fr/fr/revues/medecine/nro/e-docs/00/04/55/39/article.phtml
2010
France
French
Adrenocortical steroid therapy
corticosteroid therapy
polyradiculoneuropathy, chronic inflammatory demyelinating
immunosuppressive agents
methotrexate
treatment outcome
methotrexate
drug therapy, combination
immunoglobulins, intravenous
adrenal cortex hormones
administration, oral
journal article

---
http://www.cochrane.org/fr/CD004385
2010
United Kingdom
France
French
french abstract
meta-analysis
methotrexate
liver cirrhosis, biliary
treatment outcome
immunosuppressive agents

---
http://www.cochrane.org/fr/CD003208
2010
United Kingdom
France
French
review of literature
multiple sclerosis
methotrexate
treatment outcome
immunosuppressive agents
french abstract

---
http://www.has-sante.fr/portail/jcms/c_1015717/avis-de-la-has-sur-la-prise-en-charge-derogatoire-se-rapportant-aux-maladies-rares-vascularites-ald-21
2010
France
French
corticosteroid therapy
methotrexate
contraception
drug approval
immunosuppressive agents
mycophenolic acid
mycophenolic acid
rare diseases
systemic necrotizing angiitis
polyarteritis nodosa
chronic disease
aspirin
Granulomatosis with Polyangiitis
churg-strauss syndrome
Off-Label use
microscopic polyangiitis
acetylsalicylic acid lysinate
lysine
aspirin
-
administration, oral
ischemia
platelet aggregation inhibitors
anti-inflammatory agents, non-steroidal
chlormadinone acetate
contraceptives, oral, synthetic
guidelines for drug use
drug evaluation

---
http://www.cochrane.org/fr/CD008495
2010
false
true
false
United Kingdom
France
methotrexate
review of literature
french abstract
antirheumatic agents
arthritis, rheumatoid
methotrexate

---
http://www.has-sante.fr/portail/jcms/c_893158/ledertrexate
http://www.has-sante.fr/portail/upload/docs/application/pdf/2009-12/lederthrexate_-_ct-7258.pdf
2009
France
French
methotrexate
injections
antirheumatic agents
dermatologic agents
insurance, health, reimbursement
adult
adolescent
arthritis, rheumatoid
arthritis, psoriatic
arthritis, juvenile
psoriasis
treatment outcome
evaluation of the transparency committee

---
http://www.aboutkidshealth.ca/Fr/HealthAZ/Drugs/Pages/Methotrexate.aspx
2009
false
Canada
French
English
methotrexate
child
methotrexate
methotrexate
methotrexate
antimetabolites, antineoplastic
antimetabolites, antineoplastic
immunosuppressive agents
immunosuppressive agents
administration, oral
injections
drug information
patient education handout

---
https://smf.swisshealthweb.ch/fr/article/doi/fms.2009.06942/
2009
false
true
false
Switzerland
iatrogenic disease
medication errors
journal article
methotrexate

---
http://www.cochrane.org/fr/CD004524
2009
false
true
false
United Kingdom
France
treatment outcome
review of literature
french abstract
spondylitis, ankylosing
methotrexate

---
https://www.therapeutique-dermatologique.org/spip.php?article1375
2008
France
French
methotrexate
dermatology
scientific and technical information

---
http://www.getaid.org/outils/fiches-medicaments/le-methotrexate.html
2008
France
French
methotrexate
immunosuppressive agents
methotrexate
crohn disease
patient education handout
drug information

---
http://www.has-sante.fr/portail/upload/docs/application/pdf/ct-4152_metoject_.pdf
http://www.has-sante.fr/portail/display.jsp?id=c_517664
2007
false
France
French
methotrexate
methotrexate
arthritis, rheumatoid
antirheumatic agents
adult
psoriasis
dermatologic agents
injections
child
arthritis, juvenile
treatment outcome
evaluation of the transparency committee

---
https://www.jle.com/fr/revues/bio_rech/jpc/e-docs/00/04/37/D6/resume.md
https://www.jle.com/fr/revues/bio_rech/jpc/e-docs/00/04/37/D6/article.md?type=text.html
2007
France
French
methotrexate
Drug-Related side effects and adverse reactions
patient care management
journal article

---
http://www.has-sante.fr/portail/display.jsp?id=c_606483
http://www.has-sante.fr/portail/display.jsp?id=c_608766
2007
France
French
Adrenocortical steroid therapy
Glucocorticoid therapy
corticosteroid therapy
arthritis, rheumatoid
arthritis, rheumatoid
methotrexate
antirheumatic agents
glucocorticoids
tumor necrosis factor-alpha
anti-inflammatory agents, non-steroidal
phytotherapy
continuity of patient care
arthritis, rheumatoid
antibodies, monoclonal
immunoconjugates
interleukin 1 receptor antagonist protein
practice guideline
retraction of publication
Tumor Necrosis Factor Inhibitors

---
https://www.jle.com/fr/revues/bio_rech/jpc/e-docs/00/04/37/D6/resume.md?type=text.html
2007
France
French
methotrexate
poisoning
renal insufficiency
carboxypeptidases
patient care management
journal article

---
http://www.has-sante.fr/portail/display.jsp?id=c_400796
2006
France
evaluation of the transparency committee
methotrexate

---
http://www.has-sante.fr/portail/display.jsp?id=c_400932
2006
France
evaluation of the transparency committee
methotrexate

---
http://www.has-sante.fr/portail/display.jsp?id=c_399818
2003
France
evaluation of the transparency committee
methotrexate
injections

---
http://www.has-sante.fr/portail/display.jsp?id=c_399335
2001
France
evaluation of the transparency committee
methotrexate
White People
injections

---
https://www.cochrane.org/fr/CD000391/methotrexate-en-tant-quagent-depargne-des-steroides-dans-le-traitement-de-lasthme-chez-ladulte
1998
false
true
false
France
United Kingdom
treatment outcome
review of literature
french abstract
adult
asthma
methotrexate

---
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