" /> tetrahydrofolate dehydrogenase - CISMeF





Preferred Label : tetrahydrofolate dehydrogenase;

MeSH definition : An enzyme of the oxidoreductase class that catalyzes the reaction 7,8-dihyrofolate and NADPH to yield 5,6,7,8-tetrahydrofolate and NADPH , producing reduced folate for amino acid metabolism, purine ring synthesis, and the formation of deoxythymidine monophosphate. Methotrexate and other folic acid antagonists used as chemotherapeutic drugs act by inhibiting this enzyme. (Dorland, 27th ed) EC 1.5.1.3.;

MeSH synonym : dehydrogenase, dihydrofolate; dehydrogenase, tetrahydrofolate; reductase, folic acid; reductase, dihydrofolate; folic acid reductase; acid reductase, folic; dihydrofolate dehydrogenase; Dihydrofolate Reductase;

MeSH CAS label : 5,6,7,8-Tetrahydrofolate:NADP oxidoreductase;

Registry Number MeSH : EC 1.5.1.3;

Is substance : O;

UNII : EC 1.5.1.3;

Détails


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An enzyme of the oxidoreductase class that catalyzes the reaction 7,8-dihyrofolate and NADPH to yield 5,6,7,8-tetrahydrofolate and NADPH , producing reduced folate for amino acid metabolism, purine ring synthesis, and the formation of deoxythymidine monophosphate. Methotrexate and other folic acid antagonists used as chemotherapeutic drugs act by inhibiting this enzyme. (Dorland, 27th ed) EC 1.5.1.3.

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27/07/2025


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