tetrahydrofolate dehydrogenase

Preferred Label : tetrahydrofolate dehydrogenase;

MeSH definition : An enzyme of the oxidoreductase class that catalyzes the reaction 7,8-dihyrofolate and NADPH to yield 5,6,7,8-tetrahydrofolate and NADPH , producing reduced folate for amino acid metabolism, purine ring synthesis, and the formation of deoxythymidine monophosphate. Methotrexate and other folic acid antagonists used as chemotherapeutic drugs act by inhibiting this enzyme. (Dorland, 27th ed) EC 1.5.1.3.;

MeSH synonym : dehydrogenase, dihydrofolate; dehydrogenase, tetrahydrofolate; reductase, folic acid; reductase, dihydrofolate; folic acid reductase; acid reductase, folic; dihydrofolate dehydrogenase; Dihydrofolate Reductase;

MeSH CAS label : 5,6,7,8-Tetrahydrofolate:NADP oxidoreductase;

Registry Number MeSH : EC 1.5.1.3;

Is substance : O;

UNII : EC 1.5.1.3;

Details

Origin ID

D013762;

UMLS CUI

C0039667;

Allowable qualifiers
- administration and dosage [MeSH Qualifier]
- adverse effects [MeSH Qualifier]
- analysis [MeSH Qualifier]
- biosynthesis [MeSH Qualifier]
- blood [MeSH Qualifier]
- cerebrospinal fluid [MeSH Qualifier]
- chemical synthesis [MeSH Qualifier]
- chemistry [MeSH Qualifier]
- classification [MeSH Qualifier]
- contraindications [MeSH Qualifier]
- deficiency [MeSH Qualifier]
- drug effects [MeSH Qualifier]
- economics [MeSH Qualifier]
- genetics [MeSH Qualifier]
- history [MeSH Qualifier]
- immunology [MeSH Qualifier]
- isolation and purification [MeSH Qualifier]
- metabolism [MeSH Qualifier]
- pharmacokinetics [MeSH Qualifier]
- pharmacology [MeSH Qualifier]
- physiology [MeSH Qualifier]
- poisoning [MeSH Qualifier]
- radiation effects [MeSH Qualifier]
- standards [MeSH Qualifier]
- supply and distribution [MeSH Qualifier]
- therapeutic use [MeSH Qualifier]
- toxicity [MeSH Qualifier]
- ultrastructure [MeSH Qualifier]
- urine [MeSH Qualifier]
Indexing information
- (N-(4-amino-4-deoxy-N(10)-methylpteroyl)amino)-3-chloro-4,5-dihydro-5-isoxazoleacetic acid [MeSH Supplementary Concept]
- 2'-fluoroaminopterin [MeSH Supplementary Concept]
- 2,4-diamino-5,6-dihydro-6,6-dimethyl-5-(4'-methoxyphenyl)-s-triazine [MeSH Supplementary Concept]
- 2,4-diamino-5-((3,5-dichloro-4-(1-pyrrolo)anilino)methyl)-6-bromothieno(2,3-d)pyrimidine [MeSH Supplementary Concept]
- 2,4-diamino-5-(2'-(4-carboxyphenyl)ethynyl)-5'-(methoxybenzyl)pyrimidine [MeSH Supplementary Concept]
- 2,4-diamino-5-(3-(3-(2-(acetyloxy)ethyl)-3-benzyltriazen-1-yl)-4-chlorophenyl)-6-ethylpyrimidine [MeSH Supplementary Concept]
- 2,4-diamino-5-(4-fluoro-3-nitrophenyl)-6-ethylpyrimidine [MeSH Supplementary Concept]
- 2,4-diamino-5-methyl-6-(2',5'-dimethoxyphenylthio)pyrrolo(2,3-d)pyrimidine [MeSH Supplementary Concept]
- 2,4-diamino-6-((2',5'-dichloroanilino)methyl)pyrido(2,3-d)pyrimidine [MeSH Supplementary Concept]
- 2,4-diamino-6-((3',4',5'-trichloroanilino)methyl)pyrido(2,3-d)pyrimidine [MeSH Supplementary Concept]
- 2,4-diamino-6-(2'-O-(3-carboxypropyl)oxydibenz(b,f)azepin-5-yl)methylpteridine [MeSH Supplementary Concept]
- 2,4-diamino-6-(2-(5-carboxypent-1-yn-1-yl)-5-methoxybenzyl)-5-methylpyrido(2,3-d)pyrimidine [MeSH Supplementary Concept]
- 2,4-diamino-6-(N-(2',5'-dimethoxybenzyl)-N-methylamino)pyrido(2,3-d)pyrimidine [MeSH Supplementary Concept]
- 3'-fluoroaminopterin [MeSH Supplementary Concept]
- 3-azidopyrimethamine [MeSH Supplementary Concept]
- 4,6-diamino-1,2-dihydro-2,2-dimethyl-1-(4-phenylthiomethylphenyl)-1,3,5-triazine [MeSH Supplementary Concept]
- 5-deazaaminopterin [MeSH Supplementary Concept]
- 5-deazamethotrexate [MeSH Supplementary Concept]
- BW 1540 [MeSH Supplementary Concept]
- BW 2315 [MeSH Supplementary Concept]
- M&B 35769 [MeSH Supplementary Concept]
- N-((2,4-diaminopteridin-6-yl)methyl)dibenz(b,f)azepine [MeSH Supplementary Concept]
- N-((5-(2,4-diamino-6-pteridinyl)ethyl)-2-thenoyl)glutamic acid [MeSH Supplementary Concept]
- N-(2-amino-4-ethyl-6-methyl((pyrrolo(2,3-d)pyrimidin-5-yl)ethyl)benzoyl)glutamic acid [MeSH Supplementary Concept]
- N-(4-((2,4-diamino-5-methyl-4,7-dihydro-3H-pyrrolo(2,3-d)pyrimidin-6-yl)thio)benzoyl)glutamic acid [MeSH Supplementary Concept]
- N-(4-((2,4-diaminoquinazoline-6-yl)methylene)oxycarbonyl)benzoyl glutamic acid [MeSH Supplementary Concept]
- N-(4-((2-amino-4-oxo-5-methyl-4,7-dihydro-3H-pyrrolo(2,3-d)pyrimidin-6-yl)thio)benzoyl)glutamic acid [MeSH Supplementary Concept]
- ethylbenzoprim [MeSH Supplementary Concept]
- fluoresceinated methotrexate [MeSH Supplementary Concept]
- gamma-methylene-10-deazaaminopterin [MeSH Supplementary Concept]
- gamma-methylene-10-ethyl-10-deazaaminopterin [MeSH Supplementary Concept]
- lysine-iodoacetylmethotrexate [MeSH Supplementary Concept]
- methylbenzoprim [MeSH Supplementary Concept]
Record concept(s)
- tetrahydrofolate dehydrogenase [MeSH concept]
Related MeSH Supplementary Concept(s)
- DHFR protein, Plasmodium falciparum [MeSH Supplementary Concept]
- DHFR protein, human [MeSH Supplementary Concept]
- DHFR-ASC [MeSH Supplementary Concept]
- FolM protein, E coli [MeSH Supplementary Concept]
- R388 [MeSH Supplementary Concept]
- dihydrofolate reductase type II [MeSH Supplementary Concept]
- dihydrofolate reductase type IIIb [MeSH Supplementary Concept]
- megaloblastic anemia due to dihydrofolate reductase deficiency [MeSH Supplementary Concept]
- thymidylate synthase-dihydrofolate reductase [MeSH Supplementary Concept]
Related MeSH term(s)
- folic acid antagonists [MeSH Descriptor]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- Dihydrofolate reductase (substance) [SNOMED CT concept]
- dihydrofolate reductase [SNOMED Notion]

Keyword's position in hierarchy(ies) :

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