R388 - CISMeF

Preferred Label : R388;

MeSH note : drug-resistant form of enzyme, dihydrofolate reductase, biosynthesized by E coli that confers resistance to trimethoprim; increases resistance by 10,000 fold & mediates synthesis of additional dihydrofolate reductase which is 20,000x less susceptible to trimethoprim inhibition; do not confuse with Cat. G heading R FACTORS;

CISMeF synonym : R-factor;

MeSH synonym : R-388; R 388;

Is substance : O;

Details

Origin ID

C006094;

UMLS CUI

C0602450;

Automatic exact mappings (from CISMeF team)
- R factor (finding) [SNOMED CT concept]
- r factor [SNOMED Notion]
MeSH term(s) associated for indexing
- tetrahydrofolate dehydrogenase [MeSH Descriptor]
Record concept(s)
- R-factor [MeSH concept]
- R388 [MeSH concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]

Keyword's position in hierarchy(ies) :

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