NCIt related terms : Alimta; LY231514; N-[4-[2-(2-Amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-glutamic
Acid Disodium Salt;
NCIt definition : The disodium salt of a synthetic pyrimidine-based antifolate. Pemetrexed binds to
and inhibits the enzyme thymidylate synthase (TS) which catalyses the methylation
of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP),
an essential precursor in DNA synthesis.;
Alternative definition : NCI-GLOSS: A drug used alone or with another drug to treat certain types of non-small
cell lung cancer and malignant pleural mesothelioma. It is being studied in the treatment
of other types of cancer. Pemetrexed disodium blocks DNA synthesis and may kill cancer
cells. It is a type of folate antagonist.;
UNII : 2PKU919BA9;
CAS number : 150399-23-8;
Drug name : Alimta; Almita;
Molecule name : LY231514;
Chemical formula : C20H19N5O6.2Na;
ChEBI ID : CHEBI:63722;
Codes from synonyms : 50621; CDR0000045456; CDR0000410734; CDR0000044358;