Pemetrexed - CISMeF

Preferred Label : Pemetrexed;

NCIt synonyms : Multitargeted Antifolate; L-Glutamic Acid, N-(4-(2-(2-Amino-4,7-dihydro-4-oxo-1H-pyrrolo(2,3-d)pyrimidin-5-yl)ethyl)benzoyl); MTA; Pemetrexed Base;

NCIt definition : A synthetic pyrimidine-based antifolate. Pemetrexed binds to and inhibits the enzyme thymidylate synthase (TS), which catalyses the methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP), an essential precursor in DNA synthesis.;

UNII : 04Q9AIZ7NO;

InChIKey : WBXPDJSOTKVWSJ-ZDUSSCGKSA-N;

CAS number : 137281-23-3; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 137281-23-3 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Drug name : Pemfexy;

Chemical formula : C20H21N5O6;

NSC code : 698037;

ChEBI ID : CHEBI:63616;

Codes from synonyms : 395;

Details

Origin ID

C61614;

UMLS CUI

C0210657;

CISMeF manual mappings
- Pemetrexed [MeSH Descriptor]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Pemetrexed [MeSH Descriptor]
- Pemetrexed (substance) [SNOMED CT concept]
- Product containing pemetrexed (medicinal product) [SNOMED CT concept]
- pemetrexed [ATC Code]
- pemetrexed [MeSH concept]
Validated automatic mappings to BTNT
- pemetrexed [ATC Code]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- HemOnc Agent Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_salt_form
- Pemetrexed Disodium [NCIt concept]
has_target
- Thymidylate Synthase [NCIt concept]
is_component_of_chemotherapy_regimen
- Carboplatin/Cemiplimab/Pemetrexed Regimen [NCIt concept]
- Cisplatin/Cemiplimab/Pemetrexed Regimen [NCIt concept]
is_free_acid_or_base_form_of
- Pemetrexed Disodium [NCIt concept]

Keyword's position in hierarchy(ies) :

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