Thymidylate Synthase

Preferred Label : Thymidylate Synthase;

NCIt synonyms : dTMP Synthase; TYMS; TMP synthetase; EC 2.1.1.45; Thymidylate Synthetase;

NCIt definition : Thymidylate synthetase protein (312 aa, 36 kDa) is encoded by the human TYMS gene. The protein is a conserved transferase enzyme that catalyzes methylene tetrahydrofolate (MTHF)/dUMP conversion to dihydrofolate/dTMP in thymidine triphosphate/deoxyribonucleotide biosynthesis. Thymidylate synthetase competes with the methylene tetrahydrofolate receptor for MTHF and maintains the dTMP pool for DNA replication and repair.;

Alternative definition : NCI-GLOSS: A protein involved in making and repairing DNA (molecules inside cells that carry genetic information and pass it on from parent to child). High levels of thymidylate synthase may be involved in how certain types of cancer form and respond to treatment.;

Codes from synonyms : CDR0000486459;

Details

Origin ID

C17199;

UMLS CUI

C4043049;

Currated CISMeF NLP mapping
- thymidylate synthase [MeSH Descriptor]
- thymidylate synthase [MeSH concept]
- thymidylate synthase [SNOMED Notion]
False automatic mappings
- Thymidylate synthase (substance) [SNOMED CT concept]
OMIM relation
- Thymidylate synthetase [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- TYMS protein, human [MeSH Supplementary Concept]
- Thymidylate synthase (substance) [SNOMED CT concept]
- thymidylate synthase [SNOMED Notion]
- thymidylate synthase [MeSH Descriptor]
- thymidylate synthase [MeSH concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Enzyme Gene [NCIt concept]
- Methyltransferase Gene [NCIt concept]
- TYMS Gene [NCIt concept]
- Transferase Gene [NCIt concept]
gene_product_affected_by_chemical_or_drug
- Edatrexate [NCIt concept]
- Eniluracil/5-FU Combination Tablet [NCIt concept]
- Raltitrexed [NCIt concept]
gene_product_has_structural_domain_or_motif
- Substrate Interaction Domain [NCIt concept]
gene_product_is_biomarker_type
- Disease Marker [NCIt concept]
gene_product_is_element_in_pathway
- Folate Biosynthesis Pathway [NCIt concept]
- One Carbon Pool by Folate Pathway [NCIt concept]
- Pyrimidine Metabolism Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- DNA Repair [NCIt concept]
- DNA Replication [NCIt concept]
- Methylation [NCIt concept]
- Nucleotide Metabolic Process [NCIt concept]
is_target
- Capecitabine [NCIt concept]
- Extended Release Flucytosine [NCIt concept]
- Floxuridine [NCIt concept]
- Fluorouracil [NCIt concept]
- Fosifloxuridine Nafalbenamide [NCIt concept]
- Pemetrexed [NCIt concept]
- Pemetrexed Disodium [NCIt concept]
- Raltitrexed [NCIt concept]
- Tegafur-gimeracil-oteracil Potassium [NCIt concept]
- Topical Fluorouracil [NCIt concept]
- Trifluridine [NCIt concept]
- Trifluridine and Tipiracil Hydrochloride [NCIt concept]

Keyword's position in hierarchy(ies) :

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