Preferred Label : Fluorouracil;
NCIt synonyms : 5-Fluoro-2,4(1H,3H)-pyrimidinedione; 5-FU; Fluoro Uracil; 2,4-Dioxo-5-fluoropyrimidine; 5-Fluorouracil; 5-Fluracil; Adrucil; Fluouracil; 5 Fluorouracil; 5 Fluorouracilum; 5 FU; 5FU;
NCIt related terms : Fluril; 5-Fluoro-2,4(1H, 3H)-pyrimidinedione; Ro 2-9757; Fluracil;
NCIt definition : An antimetabolite fluoropyrimidine analog of the nucleoside pyrimidine with antineoplastic
activity. Fluorouracil and its metabolites possess a number of different mechanisms
of action. In vivo, fluoruracil is converted to the active metabolite 5-fluoroxyuridine
monophosphate (F-UMP); replacing uracil, F-UMP incorporates into RNA and inhibits
RNA processing, thereby inhibiting cell growth. Another active metabolite, 5-5-fluoro-2'-deoxyuridine-5'-O-monophosphate
(F-dUMP), inhibits thymidylate synthase, resulting in the depletion of thymidine triphosphate
(TTP), one of the four nucleotide triphosphates used in the in vivo synthesis of DNA.
Other fluorouracil metabolites incorporate into both RNA and DNA; incorporation into
RNA results in major effects on both RNA processing and functions.;
Alternative definition : NCI-GLOSS: A drug used to treat symptoms of cancer of the colon, breast, stomach,
and pancreas. It is also used in a cream to treat certain skin conditions. Fluorouracil
stops cells from making DNA and it may kill cancer cells. It is a type of antimetabolite.;
UNII : U3P01618RT;
InChIKey : GHASVSINZRGABV-UHFFFAOYSA-N;
CAS number : 51-21-8;
Drug name : Fluracedyl; Flurablastin; Ribofluor; AccuSite; Fluracil; Fluril; Fluroblastin; Carac;
Molecule name : Ro-2-9757;
Chemical formula : C4H3FN2O2;
NSC code : 19893;
ChEBI ID : CHEBI:46345;
Codes from synonyms : CDR0000046090; 01715; NSC0019893; CDR0000635764; CDR0000044752; 225;
Origin ID : C505;
UMLS CUI : C0016360;
Semantic type(s)
- UMLS correspondences (same concept)
- Validated automatic mappings to BTNT
- concept_is_in_subset
- has_target
- is_component_of_chemotherapy_regimen
https://dumas.ccsd.cnrs.fr/dumas-04602156
2023
France
dissertations, academic
Systematic Review
classification
digestion
Bioassay
Personalized
Individualized
fluorouracil measurement
Oncologist
Cumulative Dose
Assessment
Oncologists
Fluorouracil
Digestion
digestive tract function, nos
gastrointestinal agents
review literature as topic
digestant, nos
digestants
Reviewing
fluorouracil
Oncology
fluorouracil
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https://sante.gouv.fr/IMG/pdf/dgs_urgent_2023-18_5-fu.pdf
2023
France
guidelines for drug use
Treat
Binding
Bioassay
fluorouracil
Biomaterial Treatment
fluorouracil measurement
fluorouracil
Treatment
On Treatment
Cumulative Dose
During Treatment
Fluorouracil
Treatment Study
GDC Treatment Frequency Terminology
No Treatment for Diabetes
Assessment
Treatment Epoch
Therapy Object
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