Preferred Label : fluorouracil;

MeSH definition : A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.;

MeSH synonym : 5-fu; 5 fluorouracil; 5-fluorouracil; fluoruracil; 5fu;

CISMeF synonym : pharmacia brand of fluorouracil; fluorouracil teva brand; dermik brand of fluorouracil; dermatech brand of fluorouracil; roche brand of fluorouracil; ICN brand of fluorouracil; CSP brand of fluorouracil; allergan brand of fluorouracil; gry brand of fluorouracil; dakota brand of fluorouracil; ferrer brand of fluorouracil; pharmachemie brand of fluorouracil monosodium salt; haemato brand of fluorouracil; neocorp brand of fluorouracil; onkoworks brand of fluorouracil; ribosepharm brand of fluorouracil; biosyn brand of fluorouracil; riemser brand of fluorouracil; medac brand of fluorouracil; hexal brand of fluorouracil; teva brand of fluorouracil;

MeSH hyponym : adrucil; fluorouracil mononitrate; onkofluor; Fluorouracil-GRY; fluorouracilo ferrer far; fluorouracil potassium salt; fluorouracile dakota; efudix; 5-HU hexal; neofluor; 5-FU lederle; 5-Fluorouracil-biosyn; 5-FU medac; carac; fluorouracil monosodium salt; haemato-fu; fluoroplex; fluracedyl; fluorouracil monopotassium salt; ribofluor; 5 FU Lederle; 5 FU Medac; 5 HU Hexal; Fluoro-Uracile ICN; Fluoro Uracile ICN; Efudex; Flurodex; Fluorouracil GRY; Dakota, Fluorouracile; Haemato FU; 5 Fluorouracil Biosyn;

MeSH CAS label : 2,4(1H,3H)-Pyrimidinedione, 5-fluoro-;

MeSH Related Number : fluorouracil mononitrate; fluorouracil monopotassium salt; fluorouracil monosodium salt; fluorouracil potassium salt; 10318-20-4 (mono-Na salt); 51-21-8 (Fluorouracil); 57050-04-1 (K salt); 57172-36-8 (mononitrate); 68021-61-4 (mono-K salt);

Registry Number MeSH : 51-21-8;

Related CAS MeSH : 57172-36-8 (Fluorouracil mononitrate); 68021-61-4 (Fluorouracil monopotassium salt); 10318-20-4 (Fluorouracil monosodium salt); 57050-04-1 (Fluorouracil potassium salt);

Wikipedia link : https://en.wikipedia.org/wiki/Fluorouracil;

Codes EINECS : 200-085-6;

Is substance : O;

UNII : U3P01618RT;

InChIKey : GHASVSINZRGABV-UHFFFAOYSA-N;

Details


Main resources

You can consult :

A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.

https://sante.gouv.fr/IMG/pdf/dgs_urgent_2023-18_5-fu.pdf
2023
France
guidelines for drug use
Treat
Binding
Bioassay
fluorouracil
Biomaterial Treatment
fluorouracil measurement
fluorouracil
Treatment
On Treatment
Cumulative Dose
During Treatment
Fluorouracil
Treatment Study
GDC Treatment Frequency Terminology
No Treatment for Diabetes
Assessment
Treatment Epoch
Therapy Object

---
https://ansm.sante.fr/actualites/chimiotherapies-a-base-de-5-fu-ou-capecitabine-la-recherche-dun-deficit-en-dpd-dihydropyrimidine-deshydrogenase-est-obligatoire-avant-tout-debut-de-traitement
2023
false
false
false
France
French
fluorouracil
Capecitabine
antimetabolites, antineoplastic
guidelines for drug use
mandatory testing
dihydropyrimidine dehydrogenase deficiency
dihydropyrimidine dehydrogenase deficiency
Drug-Related side effects and adverse reactions

---
https://www.has-sante.fr/jcms/p_3372529/fr/fluorouracile-pfizer-fluorouracile
2022
false
false
false
France
evaluation of the transparency committee
fluorouracil
fluorouracil

---
http://telesante-centre1.ecritel.net/Thesaurus_DCC/Protocoles/DIGESTIF_*-TPF-*--DOCETAXEL-CISPLATINE-5FU-(DIGESTIF).htm
2021
false
false
false
France
French
drug information
antineoplastic combined chemotherapy protocols
TPF Regimen
TPF protocol
stomach neoplasms
Metastatic Gastroesophageal Junction Adenocarcinoma
Metastatic Gastric Adenocarcinoma
cisplatin
fluorouracil
taxoids

---
https://ansm.sante.fr/actualites/chimiotherapies-a-base-de-5-fu-ou-capecitabine-des-pop-up-pour-alerter-pharmaciens-et-medecins-sur-lobligation-dun-depistage-avant-tout-traitement
2021
false
false
false
France
French
guideline
dihydropyrimidine dehydrogenase deficiency
mass screening
medical order entry systems
Drug-Related side effects and adverse reactions
fluorouracil
Capecitabine

---
http://telesante-centre1.ecritel.net/Thesaurus_DCC/Protocoles/DIGESTIF_*-XELOX-*--CAPECITABINE--OXALIPLATINE.htm
2021
false
false
false
France
French
antineoplastic combined chemotherapy protocols
drug information
XELOX Regimen
XELOX
Rectal Adenocarcinoma
Colon Adenocarcinoma
colorectal neoplasms
deoxycytidine
fluorouracil

---
https://www.has-sante.fr/jcms/p_3214279/fr/tolak
2020
false
false
false
France
insurance, health, reimbursement
treatment outcome
fluorouracil
fluorouracil
antimetabolites, antineoplastic
ointments
adult
keratosis, actinic
facial dermatoses
scalp dermatoses
administration, topical
evaluation of the transparency committee

---
https://ansm.sante.fr/informations-de-securite/Medicaments-a-base-de-5-fluorouracile-voie-parenterale-capecitabine-tegafur-et-flucytosine-recommandations-europeennes-concernant-la-recherche-du-deficit-en-dihydropyrimidine-deshydrogenase-DPD
2020
false
false
false
France
French
guidelines for drug use
Capecitabine
tegafur
flucytosine
fluorouracil
dihydropyrimidine dehydrogenase deficiency
Drug-Related side effects and adverse reactions
mass screening

---
https://www.louvainmedical.be/fr/article/toxicite-cardiaque-et-5-fluorouracile
2019
false
false
false
Belgium
heart diseases
fluorouracil
french abstract

---
https://hal.archives-ouvertes.fr/hal-01862281
2019
false
false
false
France
fluorouracil
fluorouracil
continuity of patient care
antimetabolites, antineoplastic
antimetabolites, antineoplastic
antimetabolites, antineoplastic
neoplasms
dose-response relationship, drug
practice guideline
fluorouracil
drug monitoring

---
https://www.ansm.sante.fr/actualites/chimiotherapies-a-base-de-5-fu-ou-capecitabine-recherche-obligatoire-du-deficit-en-dpd-avant-tout-traitement
2019
false
false
false
France
French
fluorouracil
pharmacovigilance note
guidelines for drug use
Capecitabine
dihydropyrimidine dehydrogenase deficiency
mass screening
uracil
fluorouracil
Capecitabine
antimetabolites, antineoplastic
antimetabolites, antineoplastic
patient education handout

---
https://www.e-cancer.fr/content/download/263134/3704056/file/Fiche%20Patients%20-%20Chimiotherapie%205%20FU%20et%20deficit%20DPD.pdf
2019
false
false
false
France
antineoplastic agents
patient education handout
dihydropyrimidine dehydrogenase deficiency
chemotherapy
Capecitabine
fluorouracil

---
https://www.inesss.qc.ca/publications/repertoire-des-publications/publication/traitements-a-base-de-fluoropyrimidines-meilleures-strategies-pour-reduire-le-risque-de-toxicites-severes-causees-par-une-deficience-en-dihydropyrimidine-deshydrogenase.html
2019
false
true
false
false
Canada
pyrimidines
5-fluoropyrimidine
fluorouracil
Capecitabine
dihydropyrimidine dehydrogenase deficiency
colorectal neoplasms
breast neoplasms
fluorouracil
Capecitabine
dihydropyrimidine dehydrogenase deficiency
guideline

---
https://www.ansm.sante.fr/actualites/5-fu-et-deficit-en-dpd-lema-poursuit-le-travail-initie-en-france
2019
false
false
false
France
French
drug information
fluorouracil
genetic testing
Capecitabine
tegafur
flucytosine
antimetabolites
dihydropyrimidine dehydrogenase deficiency
france
europe
antimetabolites, antineoplastic
fluorouracil
Capecitabine
tegafur
flucytosine
antimetabolites
antimetabolites, antineoplastic

---
https://ansm.sante.fr/actualites/traitement-par-fluoropyrimidines-5-fluorouracile-et-capecitabine-et-deficit-en-dihydropyrimidine-deshydrogenase-dpd-lansm-invite-les-professionnels-de-sante-a-appliquer-les-nouvelles-recommandations-emises-par-linca-et-la-has
2018
false
false
false
false
France
French
guidelines for drug use
Capecitabine
fluorouracil
uracil
mass screening
dihydropyrimidine dehydrogenase deficiency
antimetabolites, antineoplastic
blood chemical analysis
Drug-Related side effects and adverse reactions

---
https://ansm.sante.fr/actualites/Prevention-des-effets-indesirables-graves-lies-a-un-deficit-en-dihydropyrimidine-deshydrogenase-DPD-lors-de-traitement-par-fluoropyrimidines-5-fluorouracile-et-capecitabine
2018
false
false
false
false
France
French
dihydropyrimidine dehydrogenase deficiency
pharmacovigilance note
Drug-Related side effects and adverse reactions
Capecitabine
fluorouracil
mass screening
antineoplastic agents
antineoplastic combined chemotherapy protocols
fluorouracil
capecitabine
genetic testing
antidotes
uridine triacetate
Poisoning caused by fluorouracil (disorder)
Capecitabine
fluorouracil
poisoning
uridine triacetate
acetates
uridine
uridine
acetates
uridine

---
https://www.ansm.sante.fr/actualites/prevention-des-effets-indesirables-graves-lies-a-un-deficit-en-dihydropyrimidine-deshydrogenase-dpd-lors-de-traitement-par-fluoropyrimidines-5-fluorouracile-et-capecitabine
2018
false
false
false
France
French
dihydropyrimidine dehydrogenase deficiency
Drug-Related side effects and adverse reactions
Capecitabine
fluorouracil
dihydropyrimidine dehydrogenase deficiency
mass screening
dihydropyrimidine dehydrogenase deficiency
antimetabolites, antineoplastic
pharmacovigilance note
antidotes
uridine triacetate
Poisoning caused by fluorouracil (disorder)
Poisoning caused by fluorouracil (disorder)
poisoning
poisoning
genetic testing
acetates
uridine
uridine

---
http://www.has-sante.fr/portail/jcms/c_2751867/fr/vectibix
2017
false
France
French
IFL protocol
Metastatic colorectal cancer
Tyrosine Kinase Inhibitors
evaluation of the transparency committee
infusions, intravenous
panitumumab
antineoplastic combined chemotherapy protocols
colorectal neoplasms
neoplasm metastasis
KRAS protein, human
colorectal neoplasms
antineoplastic agents
antineoplastic agents
genetic testing
treatment outcome
survival analysis
proto-oncogene proteins
ras proteins
antibodies, monoclonal
antibodies, monoclonal
Proto-Oncogene proteins p21(ras)
antineoplastic combined chemotherapy protocols
camptothecin
camptothecin
leucovorin
fluorouracil
ErbB Receptors
Panitumumab
Panitumumab

---
https://www.minerva-ebp.be/FR/Article/2031
2016
false
false
false
false
Belgium
French
critical appraisal or critical reading
keratosis, actinic
fluorouracil
placebos
face
ear
comparative study

---
http://www.unicancer.fr/sites/default/files/guidelines_gpco-unicancer_dpd_et_fluoropyrimidines.pdf
2016
false
false
false
France
French
dihydropyrimidine dehydrogenase deficiency
mass screening
fluorouracil
patient safety
fluorouracil
Capecitabine
capecitabine
antimetabolites, antineoplastic
practice guideline
fluorouracil
fluorouracil
antimetabolites, antineoplastic
Capecitabine
Capecitabine
dihydropyrimidine dehydrogenase deficiency
genetic screening
france
continuity of patient care
genetic testing

---
http://www.has-sante.fr/portail/jcms/c_2565124/fr/efudix
http://www.has-sante.fr/portail/jcms/c_400913/fr/efudix-5-pour-cent-creme-tube-de-20-g-code-cip-321-843-2
2015
false
France
French
queyrat's erythroplasia
antimetabolites
antimetabolites, antineoplastic
insurance, health, reimbursement
fluorouracil
keratosis, actinic
condylomata acuminata
bowen's disease
erythroplasia
treatment outcome
administration, topical
fluorouracil
evaluation of the transparency committee

---
http://base-donnees-publique.medicaments.gouv.fr/extrait.php?specid=65248246
2014
false
false
false
France
French
summary of product characteristics
pill, nos
capecitabine
dandruff
tablets
capecitabine
compression, nos
seborrhea sicca
dandruff
deoxycytidine
fluorouracil

---
http://base-donnees-publique.medicaments.gouv.fr/afficheGroupeGene.php?idGrp=1095
2014
false
false
false
France
French
drug information
tablets
compression, nos
seborrhea sicca
generic drug, nos
dandruff
drugs, generic
capecitabine
pill, nos
waiting lists
capecitabine
dandruff
deoxycytidine
fluorouracil

---
http://base-donnees-publique.medicaments.gouv.fr/extrait.php?specid=61673260
2014
false
false
false
France
French
summary of product characteristics
pill, nos
capecitabine
dandruff
tablets
compression, nos
capecitabine
seborrhea sicca
dandruff
deoxycytidine
fluorouracil

---
http://base-donnees-publique.medicaments.gouv.fr/afficheGroupeGene.php?idGrp=1094
2014
false
false
false
France
French
drug information
dandruff
generic drug, nos
capecitabine
pill, nos
waiting lists
seborrhea sicca
capecitabine
compression, nos
tablets
drugs, generic
dandruff
deoxycytidine
fluorouracil

---
http://base-donnees-publique.medicaments.gouv.fr/extrait.php?specid=63611923
2014
false
false
false
France
French
summary of product characteristics
dandruff
seborrhea sicca
capecitabine
capecitabine
compression, nos
tablets
pill, nos
dandruff
deoxycytidine
fluorouracil

---
http://base-donnees-publique.medicaments.gouv.fr/extrait.php?specid=65970775
2014
false
false
false
France
French
summary of product characteristics
pill, nos
capecitabine
seborrhea sicca
capecitabine
dandruff
tablets
compression, nos
dandruff
deoxycytidine
fluorouracil

---
http://base-donnees-publique.medicaments.gouv.fr/extrait.php?specid=65502762
2014
false
false
false
France
French
summary of product characteristics
capecitabine
tablets
seborrhea sicca
dandruff
pill, nos
compression, nos
capecitabine
dandruff
deoxycytidine
fluorouracil

---
http://base-donnees-publique.medicaments.gouv.fr/extrait.php?specid=69087947
2014
false
false
false
France
French
package leaflet
summary of product characteristics
dandruff
pill, nos
compression, nos
tablets
seborrhea sicca
capecitabine
dandruff
deoxycytidine
fluorouracil

---
http://base-donnees-publique.medicaments.gouv.fr/extrait.php?specid=62990833
2014
false
false
false
France
French
summary of product characteristics
package leaflet
seborrhea sicca
tablets
pill, nos
capecitabine
compression, nos
dandruff
dandruff
deoxycytidine
fluorouracil

---
http://base-donnees-publique.medicaments.gouv.fr/extrait.php?specid=64933293
2014
false
false
false
France
French
summary of product characteristics
capecitabine
dandruff
seborrhea sicca
capecitabine
compression, nos
pill, nos
tablets
dandruff
deoxycytidine
fluorouracil

---
http://www.cochrane.org/fr/CD001132/le-5-fluorouracil-par-rapport-a-un-placebo-ou-a-labsence-dintervention-pendant-ou-apres-la-chirurgie-du-glaucome
false
false
false
France
United Kingdom
review of literature
french abstract
fluorouracil
glaucoma
treatment outcome
wound healing
trabeculectomy

---
http://base-donnees-publique.medicaments.gouv.fr/extrait.php?specid=61174695
2014
false
false
false
France
French
summary of product characteristics
capecitabine
dandruff
capecitabine
tablets
seborrhea sicca
compression, nos
pill, nos
dandruff
deoxycytidine
fluorouracil

---
http://base-donnees-publique.medicaments.gouv.fr/extrait.php?specid=69139187
2014
false
false
false
France
French
summary of product characteristics
tablets
compression, nos
capecitabine
pill, nos
seborrhea sicca
capecitabine
dandruff
dandruff
deoxycytidine
fluorouracil

---
http://base-donnees-publique.medicaments.gouv.fr/extrait.php?specid=69475597
2014
false
false
false
France
French
summary of product characteristics
pill, nos
capecitabine
compression, nos
tablets
dandruff
seborrhea sicca
capecitabine
dandruff
deoxycytidine
fluorouracil

---
http://base-donnees-publique.medicaments.gouv.fr/extrait.php?specid=65982788
2014
false
false
false
France
French
summary of product characteristics
capecitabine
dandruff
capecitabine
compression, nos
seborrhea sicca
tablets
pill, nos
dandruff
deoxycytidine
fluorouracil

---
http://base-donnees-publique.medicaments.gouv.fr/extrait.php?specid=60044987
2014
false
false
false
France
French
summary of product characteristics
compression, nos
tablets
dandruff
capecitabine
pill, nos
capecitabine
seborrhea sicca
dandruff
deoxycytidine
fluorouracil

---
http://base-donnees-publique.medicaments.gouv.fr/extrait.php?specid=62969369
2014
false
false
false
France
French
summary of product characteristics
dandruff
seborrhea sicca
pill, nos
tablets
capecitabine
compression, nos
capecitabine
dandruff
deoxycytidine
fluorouracil

---
http://base-donnees-publique.medicaments.gouv.fr/extrait.php?specid=69309579
2014
false
false
false
France
French
summary of product characteristics
tablets
seborrhea sicca
capecitabine
pill, nos
dandruff
capecitabine
compression, nos
dandruff
deoxycytidine
fluorouracil

---
http://base-donnees-publique.medicaments.gouv.fr/extrait.php?specid=66104989
2014
false
false
false
France
French
summary of product characteristics
capecitabine
seborrhea sicca
pill, nos
dandruff
tablets
compression, nos
capecitabine
dandruff
deoxycytidine
fluorouracil

---
http://www.cochrane.org/fr/CD006421
2013
United Kingdom
France
French
review of literature
meta-analysis
heparin, low-molecular-weight
anticoagulants
intravitreal injections
fluorouracil
vitreoretinopathy, proliferative
postoperative complications
retinal detachment
ophthalmologic surgical procedures
comparative study
treatment outcome
anticoagulotherapy

---
http://agence-prd.ansm.sante.fr/php/ecodex/extrait.php?specid=67294648
2012
France
summary of product characteristics
package leaflet
fluorouracil

---
http://agence-prd.ansm.sante.fr/php/ecodex/extrait.php?specid=65502207
2012
France
summary of product characteristics
package leaflet
fluorouracil

---
http://agence-prd.ansm.sante.fr/php/ecodex/extrait.php?specid=64590923
2012
France
summary of product characteristics
package leaflet
fluorouracil

---
http://agence-prd.ansm.sante.fr/php/ecodex/extrait.php?specid=61146475
2012
France
summary of product characteristics
package leaflet
fluorouracil

---
http://agence-prd.ansm.sante.fr/php/ecodex/extrait.php?specid=65424609
2012
France
summary of product characteristics
package leaflet
fluorouracil

---
http://agence-prd.ansm.sante.fr/php/ecodex/extrait.php?specid=63616817
2012
France
summary of product characteristics
package leaflet
fluorouracil

---
http://agence-prd.ansm.sante.fr/php/ecodex/extrait.php?specid=69118428
2012
France
summary of product characteristics
package leaflet
fluorouracil

---
http://agence-prd.ansm.sante.fr/php/ecodex/extrait.php?specid=68136850
2012
France
summary of product characteristics
package leaflet
fluorouracil

---
http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=FR&Expert=217064
2011
France
scientific and technical information
fluorouracil
drug overdose

---
https://www.inspq.qc.ca/toxicologie-clinique/le-triacetate-d-uridine-un-nouvel-antidote-pour-le-traitement-de-l-intoxication-au-5-fluorouracil
2011
false
Canada
French
acetates
uridine triacetate
journal article
antidotes
poisoning
fluorouracil
uridine

---
http://www.cochrane.org/fr/CD007046
2010
false
true
false
France
United Kingdom
fluorouracil
treatment outcome
review of literature
french abstract
colorectal neoplasms

---
http://www.cochrane.org/fr/CD006562
2010
false
true
false
United Kingdom
France
condylomata acuminata
fluorouracil
treatment outcome
review of literature
french abstract

---
http://www.aboutkidshealth.ca/en/healthaz/drugs/pages/fluorouracil-for-injection.aspx?k=fluoro-uracile;+administration+de+m%c3%a9dicaments;+agents+de+chimioth%c3%a9rapie;+cancer;+intraveineuse
http://www.aboutkidshealth.ca/Fr/HealthAZ/Drugs/Pages/Fluorouracil-for-Injection.aspx
2010
Canada
French
English
child
injections
fluorouracil
fluorouracil
antimetabolites, antineoplastic
antimetabolites, antineoplastic
fluorouracil
patient education handout
drug information

---
2008
false
true
false
France
French
IFL protocol
FOLFIRI Regimen
patient education handout
drug information
antineoplastic combined chemotherapy protocols
camptothecin
leucovorin
fluorouracil

---
http://www.has-sante.fr/portail/display.jsp?id=c_399791
2003
France
evaluation of the transparency committee
fluorouracil

---
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