camptothecin - CISMeF

Preferred Label : camptothecin;

MeSH definition : An alkaloid isolated from the stem wood of the Chinese tree, Camptotheca acuminata. This compound selectively inhibits the nuclear enzyme DNA TOPOISOMERASES, TYPE I. Several semisynthetic analogs of camptothecin have demonstrated antitumor activity.;

MeSH synonym : camptothecine;

MeSH CAS label : 1H-Pyrano(3',4':6,7)indolizino(1,2-b)quinoline-3,14(4H,12H)-dione, 4-ethyl-4-hydroxy-, (S)-;

MeSH Related Number : 7689-03-4 (Camptothecin);

Registry Number MeSH : 7689-03-4;

Wikipedia link : https://en.wikipedia.org/wiki/Camptothecin;

Is substance : O;

UNII : XT3Z54Z28A;

InChIKey : VSJKWCGYPAHWDS-FQEVSTJZSA-N;

Details

Origin ID

D002166;

UMLS CUI

C0006812;

Allowable qualifiers
- administration and dosage [MeSH Qualifier]
- adverse effects [MeSH Qualifier]
- agonists [MeSH Qualifier]
- analogs and derivatives [MeSH Qualifier]
- analysis [MeSH Qualifier]
- antagonists and inhibitors [MeSH Qualifier]
- biosynthesis [MeSH Qualifier]
- blood [MeSH Qualifier]
- cerebrospinal fluid [MeSH Qualifier]
- chemical synthesis [MeSH Qualifier]
- chemistry [MeSH Qualifier]
- classification [MeSH Qualifier]
- contraindications [MeSH Qualifier]
- economics [MeSH Qualifier]
- history [MeSH Qualifier]
- immunology [MeSH Qualifier]
- isolation and purification [MeSH Qualifier]
- metabolism [MeSH Qualifier]
- pharmacokinetics [MeSH Qualifier]
- pharmacology [MeSH Qualifier]
- poisoning [MeSH Qualifier]
- radiation effects [MeSH Qualifier]
- standards [MeSH Qualifier]
- supply and distribution [MeSH Qualifier]
- therapeutic use [MeSH Qualifier]
- toxicity [MeSH Qualifier]
- urine [MeSH Qualifier]
Currated CISMeF NLP mapping
- Camptothecin [NCIt concept]
- Camptothecin (substance) [SNOMED CT concept]
- camptothecin [SNOMED Notion]
Pharmacological action(s)
- antineoplastic agents, phytogenic [MeSH Descriptor]
- enzyme inhibitors [MeSH Descriptor]
- topoisomerase I inhibitors [MeSH Descriptor]
Record concept(s)
- camptothecin [MeSH concept]
Related MeSH Supplementary Concept(s)
- (20S)-10-(3-aminopropyloxy)-7-ethylcamptothecin [MeSH Supplementary Concept]
- 10,11-methylenedioxy-14-azacamptothecin [MeSH Supplementary Concept]
- 10,11-methylenedioxy-20-camptothecin [MeSH Supplementary Concept]
- 10,11-methylenedioxycamptothecin [MeSH Supplementary Concept]
- 10-(2-pyrazolylethoxy)camptothecin [MeSH Supplementary Concept]
- 10-O-(1-beta-D-glycosyl)camptothecin [MeSH Supplementary Concept]
- 10-amino-7-ethylcamptothecin [MeSH Supplementary Concept]
- 10-aminocamptothecin [MeSH Supplementary Concept]
- 10-bromoacetamidomethylcamptothecin [MeSH Supplementary Concept]
- 10-hydroxycamptothecin [MeSH Supplementary Concept]
- 10-methoxy-9-nitrocamptothecin [MeSH Supplementary Concept]
- 10-methoxycamptothecin [MeSH Supplementary Concept]
- 11-hydroxycamptothecin [MeSH Supplementary Concept]
- 12-nitrocamptothecin [MeSH Supplementary Concept]
- 14-azacamptothecin [MeSH Supplementary Concept]
- 16a-thiocamptothecin [MeSH Supplementary Concept]
- 18-hydroxycamptothecin [MeSH Supplementary Concept]
- 2,3-dihydro-9-ethyl-5-fluoro-9-hydroxy-4-methyl-1H,12H-benzo(de)pyrano(3',4'-6,7)indolizino(1,2-b)quinoline-10,13(9H,15H)-dione [MeSH Supplementary Concept]
- 20(S)-sulfonylamidine camptothecin [MeSH Supplementary Concept]
- 20-O-(Nalpha-(4-(3-O-methylfucopyranosyloxy)phenylaminothiocarbonyl)histidylvalyl)camptothecin [MeSH Supplementary Concept]
- 20-O-glucopyranosyl camptothecin [MeSH Supplementary Concept]
- 20-fluorocamptothecin [MeSH Supplementary Concept]
- 20-glycinate-10,11-methylenedioxycamptothecin [MeSH Supplementary Concept]
- 20-glycinate-7-chloromethyl-10,11-methylenedioxycamptothecin [MeSH Supplementary Concept]
- 4-deshydroxy-4-(N-methyl-(2-(((5-methoxy-1,2-dimethyl-4,7-dioxoindol-3-yl)methoxycarbonyl)(methyl)amino)ethyl)carbamoylmethyl)camptothecin [MeSH Supplementary Concept]
- 4-deshydroxy-4-(N-methyl-(2-(((5-nitrofur-2-yl)methoxycarbonyl)(methyl)amino)ethyl)carbamoylmethyl)camptothecin [MeSH Supplementary Concept]
- 5-aminocamptothecin [MeSH Supplementary Concept]
- 5-ethyl-9,10-difluoro-1,4,5,13-tetrahydro-5-hydroxy-3H,15H-oxepino(3',4'-6,7)indolizino(1,2-b)quinoline-3,15-dione [MeSH Supplementary Concept]
- 7-((3-piperidyl)-1-propynyl)camptothecin [MeSH Supplementary Concept]
- 7-butyl-10-amino-camptothecin [MeSH Supplementary Concept]
- 7-butyl-10-amino-camptothecin-beta-alanine-lysine [MeSH Supplementary Concept]
- 7-chloromethyl-10,11-methylenedioxycamptothecin [MeSH Supplementary Concept]
- 7-cyanocamptothecin [MeSH Supplementary Concept]
- 7-cyclohexylfluorocamptothecin [MeSH Supplementary Concept]
- 7-ethyl-10-(4-amino-1-piperidino)carbonyloxycamptothecine [MeSH Supplementary Concept]
- 7-ethyl-10-hydroxy-20-deoxyaminocamptothecin [MeSH Supplementary Concept]
- 7-ethyl-10-hydroxycamptothecin acetic acid [MeSH Supplementary Concept]
- 7-ethyl-10-hydroxycamptothecin beta-glucuronide [MeSH Supplementary Concept]
- 7-ethyl-10-hydroxycamptothecin glucuronide [MeSH Supplementary Concept]
- 7-ethyl-10-methoxy-20-deoxyaminocamptothecin [MeSH Supplementary Concept]
- 7-ethyl-14-aminocamptothecin [MeSH Supplementary Concept]
- 7-ethylcamptothecin [MeSH Supplementary Concept]
- 7-methyl-10,11-ethylenedioxy-20-camptothecin [MeSH Supplementary Concept]
- 7-methyl-10-bromoacetamidomethylcamptothecin [MeSH Supplementary Concept]
- 7-methyl-9-((2-(2-methylpiperidin-1-yl)acetyl)amino)homocamptothecin [MeSH Supplementary Concept]
- 7-tert-butoxyiminomethylcamptothecin [MeSH Supplementary Concept]
- 7-tert-butyldimethylsilyl-10-hydroxycamptothecin [MeSH Supplementary Concept]
- 7-tert-butyldimethylsilyl-10-hydroxyhomocamptothecin [MeSH Supplementary Concept]
- 7-thiomethyl-camptothecin [MeSH Supplementary Concept]
- 9,16-diethyl-2,3-dihydro-9-hydroxy-12H-1,4-oxazino(3,2-f)pyrano(3',4'-6,7)indolizino(1,2-b)quinoline-10,13(9H,15H)-dione [MeSH Supplementary Concept]
- 9-(benzoylamino)-7-methylhomocamptothecin [MeSH Supplementary Concept]
- 9-aminocamptothecin [MeSH Supplementary Concept]
- 9-aminocamptothecin glucuronide [MeSH Supplementary Concept]
- 9-aminocamptothecin lactone [MeSH Supplementary Concept]
- 9-methoxycamptothecin [MeSH Supplementary Concept]
- BMS 286309 [MeSH Supplementary Concept]
- BMS 422461 [MeSH Supplementary Concept]
- BN 80927 [MeSH Supplementary Concept]
- CH 0793076 [MeSH Supplementary Concept]
- CPT-10-B [MeSH Supplementary Concept]
- CPT417 [MeSH Supplementary Concept]
- DE-310 cpd [MeSH Supplementary Concept]
- DHA-HCPT conjugate [MeSH Supplementary Concept]
- DRF-1042 [MeSH Supplementary Concept]
- DTS-108 [MeSH Supplementary Concept]
- EZN-2208 [MeSH Supplementary Concept]
- FOLFOXIRI protocol [MeSH Supplementary Concept]
- GI 149893 [MeSH Supplementary Concept]
- IDN5174 [MeSH Supplementary Concept]
- IFL protocol [MeSH Supplementary Concept]
- IROX protocol [MeSH Supplementary Concept]
- IT-101 [MeSH Supplementary Concept]
- JF-10-81 [MeSH Supplementary Concept]
- MXN-004 [MeSH Supplementary Concept]
- NSC 100880 [MeSH Supplementary Concept]
- NSC606985 [MeSH Supplementary Concept]
- O-acetylcamptothecin [MeSH Supplementary Concept]
- ONCOFID-S [MeSH Supplementary Concept]
- RJT-101 [MeSH Supplementary Concept]
- RPR 121056 [MeSH Supplementary Concept]
- S 38809 [MeSH Supplementary Concept]
- SN38-Glu [MeSH Supplementary Concept]
- ST 1481 [MeSH Supplementary Concept]
- ST 1698 [MeSH Supplementary Concept]
- ST 1976 [MeSH Supplementary Concept]
- STA-12-8666 [MeSH Supplementary Concept]
- TLC 388 [MeSH Supplementary Concept]
- XMT 1001 [MeSH Supplementary Concept]
- ZBH-1205 [MeSH Supplementary Concept]
- belotecan [MeSH Supplementary Concept]
- camptothecin copper(II) complex [MeSH Supplementary Concept]
- camptothecin, C20-propionate ester [MeSH Supplementary Concept]
- camptothecin-20(s)-O-(N-(3'alpha,12alpha-dihydroxy-24'-carbonyl-5'beta-cholan))-lysine [MeSH Supplementary Concept]
- camptothecin-20-glycinate ester [MeSH Supplementary Concept]
- capecitabine-irinotecan combination [MeSH Supplementary Concept]
- chimmitecan [MeSH Supplementary Concept]
- cositecan [MeSH Supplementary Concept]
- diflomotecan [MeSH Supplementary Concept]
- exatecan [MeSH Supplementary Concept]
- glycyl-DX-8951 [MeSH Supplementary Concept]
- homocamptothecin [MeSH Supplementary Concept]
- hydroxycamptothecinum [MeSH Supplementary Concept]
- irinotecan sucrosofate [MeSH Supplementary Concept]
- isocamptothecin A [MeSH Supplementary Concept]
- isocamptothecin B [MeSH Supplementary Concept]
- lurtotecan [MeSH Supplementary Concept]
- maleimidohexyl-arginyl-arginyl-alanyl-leucyl-alanyl-leucyl-alanyl-camptothecin [MeSH Supplementary Concept]
- monomethoxypolyethylene glycol-carbonyl-glycyl-leucyl-phenylalanyl-glycyl-10-amino-7-ethylcamptothecin [MeSH Supplementary Concept]
- namitecan [MeSH Supplementary Concept]
- patritumab deruxtecan [MeSH Supplementary Concept]
- pegamotecan [MeSH Supplementary Concept]
- poly(ethylene glycol)-camptothecin conjugate [MeSH Supplementary Concept]
- polyglutamate camptothecin [MeSH Supplementary Concept]
- pumiloside [MeSH Supplementary Concept]
- rubitecan [MeSH Supplementary Concept]
- sacituzumab govitecan [MeSH Supplementary Concept]
- simmitecan [MeSH Supplementary Concept]
- trastuzumab deruxtecan [MeSH Supplementary Concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Camptothecin [NCIt concept]
- Camptothecin (substance) [SNOMED CT concept]
- camptothecin [SNOMED Notion]

Keyword's position in hierarchy(ies) :

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