Preferred Label : Camptothecin;
NCIt synonyms : 20-(S)-camptothecine; camptothecine; (S)-4-ethyl-4-hydroxy-1H-pyrano-[3',4':6,7]indolozino[1,2-b]quinoline-3,14(4H,12H)-dione; 1H-Pyrano[3',3'.6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, 4-ethyl-4hydroxy-(S)-(9CI);
NCIt related terms : ( )-Camptothecin; 21, 22-Secocamptothecin-21-oic acid lactone; 20(S)-Camptothecine;
NCIt definition : An alkaloid isolated from the Chinese tree Camptotheca acuminata, with antineoplastic
activity. During the S phase of the cell cycle, camptothecin selectively stabilizes
topoisomerase I-DNA covalent complexes, thereby inhibiting religation of topoisomerase
I-mediated single-strand DNA breaks and producing potentially lethal double-strand
DNA breaks when encountered by the DNA replication machinery. (NCI);
Alternative definition : NCI-GLOSS: An anticancer drug that belongs to the family of drugs called topoisomerase
inhibitors.;
UNII : XT3Z54Z28A;
InChIKey : VSJKWCGYPAHWDS-FQEVSTJZSA-N;
CAS number : 7689-03-4;
Chemical formula : C20H16N2O4;
NSC code : 94600;
ChEBI ID : CHEBI:27656;
Codes from synonyms : 09054; CDR0000045181; NSC0094600;
Origin ID : C338;
UMLS CUI : C0006812;
Currated CISMeF NLP mapping
- Semantic type(s)
- UMLS correspondences (same concept)
- concept_is_in_subset
- has_salt_form
- is_free_acid_or_base_form_of
