Camptothecin Sodium

Preferred Label : Camptothecin Sodium;

NCIt synonyms : Camptothecin Sodium Salt;

NCIt related terms : Sodium camptothecin; Camptothecin, sodium salt;

NCIt definition : The sodium salt of camptothecin, an alkaloid isolated from the Chinese tree Camptotheca acuminata, with antineoplastic activity. During the S phase of the cell cycle, camptothecin selectively stabilizes topoisomerase I-DNA covalent complexes, thereby inhibiting religation of topoisomerase I-mediated single-strand DNA breaks and producing potentially lethal double-strand DNA breaks when encountered by the DNA replication machinery. The sodium salt of camptothecin is more water-soluble than the parent molecule. (NCI04);

UNII : 3L6CT9UWOM;

CAS number : 25387-67-1;

NSC code : 100880;

Codes from synonyms : NSC0100880;

Détails

Origin ID

C2344;

UMLS CUI

C1516156;

Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
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- Camptothecin [NCIt concept]
is_salt_form_of
- Camptothecin [NCIt concept]

Position du mot-clé dans l'(les) arborescence(s) :

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