Preferred Label : leucovorin;
MeSH definition : The active metabolite of FOLIC ACID. Leucovorin is used principally as an antidote
to FOLIC ACID ANTAGONISTS.;
MeSH synonym : acid, folinic; folinic acid; leukovorin; leukovorum; folinic acid-sf; folinic acid sf;
MeSH hyponym : leucovorin, (DL)-Isomer; Leucovorin, Calcium (1:1) Salt; leucovorin, (R)-Isomer; N(5)-Formyltetrahydrofolate; wellcovorin; leucovorin, calcium (1:1) salt, (DL)-Isomer; leucovorin, (D)-Isomer; leucovorin, calcium (1:1) salt, pentahydrate; citrovorum factor; leucovorin, monosodium salt; Factor, Citrovorum; Calcium Leucovorin; Leucovorin, Calcium; Calcium Folinate; Folinate, Calcium; Monosodium Salt Leucovorin; 5-Formyltetrahydropteroylglutamate; 5 Formyltetrahydropteroylglutamate; 5-Formyltetrahydrofolate; 5 Formyltetrahydrofolate;
MeSH CAS label : L-Glutamic acid, N-(4-(((2-amino-5-formyl-1,4,5,6,7,8-hexahydro-4-oxo-6-pteridinyl)methyl)amino)benzoyl)-;
MeSH Related Number : leucovorin, (D)-Isomer; leucovorin, (DL)-Isomer; leucovorin, (R)-Isomer; leucovorin, calcium (1:1) salt, (DL)-Isomer; leucovorin, calcium (1:1) salt, pentahydrate; leucovorin, monosodium salt; leucovorin, calcium (1:1) salt; 58-05-9 (Leucovorin); 1492-18-8; 22350-60-3; 42476-21-1; 54353-24-1; 6035-45-6; 67005-79-2; 73951-54-9; RPR1R4C0P4;
Registry Number MeSH : 58-05-9;
Related CAS MeSH : 54353-24-1 (Leucovorin, (D)-Isomer); 22350-60-3 (Leucovorin, (DL)-Isomer); 73951-54-9 (Leucovorin, (R)-Isomer); 67005-79-2 (Leucovorin, calcium (1:1) salt, (DL)-Isomer); 6035-45-6 (Leucovorin, calcium (1:1) salt, pentahydrate); 42476-21-1 (Leucovorin, monosodium salt); 1492-18-8 (Leucovorin, calcium (1:1) salt);
MeSH annotation : deficiency: coordinate LEUCOVORIN /defic (IM) with FOLIC ACID DEFICIENCY (IM);
Wikipedia link : https://en.wikipedia.org/wiki/Folinic acid;
Codes EINECS : 200-361-6;
Is substance : O;
UNII : Q573I9DVLP;
InChIKey : VVIAGPKUTFNRDU-ABLWVSNPSA-N;
Origin ID : D002955;
UMLS CUI : C0023413;
ATC code(s)
- Allowable qualifiers
- CISMeF manual mappings
- False automatic mappings
- Pharmacological action(s)
- Record concept(s)
- Related MeSH Supplementary Concept(s)
- See also inter- (CISMeF)
- Semantic type(s)
- UMLS correspondences (same concept)
- Validated automatic mappings to BTNT
The active metabolite of FOLIC ACID. Leucovorin is used principally as an antidote
to FOLIC ACID ANTAGONISTS.
https://www.has-sante.fr/jcms/p_3508907/fr/folinate-de-calcium-kalceks-folinate-de-calcium-hydrate-oncologie
2024
false
false
false
France
drugs, generic
treatment outcome
insurance, health, reimbursement
calcium folinate
injections, intramuscular
infusions, intravenous
antidotes
methotrexate
Drug-Related side effects and adverse reactions
Methotrexate Toxicity
adult
child
antineoplastic combined chemotherapy protocols
Leukovorin rescue (procedure)
evaluation of the transparency committee
leucovorin
Leucovorin, Calcium (1:1) Salt
---
https://www.has-sante.fr/jcms/p_3259736/fr/folinate-de-calcium-altan
2021
false
false
false
France
calcium folinate
treatment outcome
insurance, health, reimbursement
folic acid antagonists
antidotes
cytostatic agents
Antineoplastic overdose (disorder)
Antineoplastic poisoning (disorder)
methotrexate
Leukovorin rescue (procedure)
evaluation of the transparency committee
Leucovorin, Calcium (1:1) Salt
leucovorin
---
https://www.has-sante.fr/jcms/p_3146308/fr/folinate-de-calcium-hikma
2020
false
false
false
France
drugs, generic
evaluation of the transparency committee
leucovorin
Leucovorin, Calcium (1:1) Salt
---
https://www.has-sante.fr/portail/jcms/c_2854439/fr/folinate-de-calcium-ebewe
2018
false
false
false
false
France
French
evaluation of the transparency committee
drugs, generic
Leucovorin, Calcium (1:1) Salt
leucovorin
---
http://www.has-sante.fr/portail/jcms/c_2751867/fr/vectibix
2017
false
France
French
IFL protocol
Metastatic colorectal cancer
Tyrosine Kinase Inhibitors
evaluation of the transparency committee
infusions, intravenous
panitumumab
antineoplastic combined chemotherapy protocols
colorectal neoplasms
neoplasm metastasis
KRAS protein, human
colorectal neoplasms
antineoplastic agents
antineoplastic agents
genetic testing
treatment outcome
survival analysis
proto-oncogene proteins
ras proteins
antibodies, monoclonal
antibodies, monoclonal
Proto-Oncogene proteins p21(ras)
antineoplastic combined chemotherapy protocols
camptothecin
camptothecin
leucovorin
fluorouracil
ErbB Receptors
Panitumumab
Panitumumab
---
http://www.has-sante.fr/portail/jcms/c_2027362/fr/folinoral
http://www.has-sante.fr/portail/jcms/c_900475/folinoral
2015
false
France
French
pyrimethamine induced hematotoxicity
pyrimethamine induced hematotoxicity
toxic accident due to methotrexate
toxic accident due to methotrexate
methotrexate
trimethoprim
salazopyrine
pyrimethamine
leucovorin
administration, oral
calcium folinate
insurance, health, reimbursement
Drug-Related side effects and adverse reactions
Drug-Related side effects and adverse reactions
Leucovorin, Calcium (1:1) Salt
evaluation of the transparency committee
drug combinations
glucosamine
glucosamine
sulfasalazine
---
http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=FR&Expert=79097
2014
false
true
false
France
scientific and technical information
leucovorin
Epilepsy
convulsions
epilepsy
---
http://www.has-sante.fr/portail/jcms/c_1671513/fr/lederfoline
http://www.has-sante.fr/portail/jcms/c_1671512/fr/lederfoline-16102013-avis-ct12921
http://www.has-sante.fr/portail/display.jsp?id=c_468602
2013
France
French
evaluation of the transparency committee
administration, oral
Leucovorin, Calcium (1:1) Salt
calcium folinate
leucovorin
insurance, health, reimbursement
methotrexate
Drug-Related side effects and adverse reactions
Drug-Related side effects and adverse reactions
trimethoprim
salazopyrine
pyrimethamine
sulfasalazine
drug combinations
glucosamine
---
http://www.cochrane.org/fr/CD000951
http://www.cochrane.org/fr/CD000951/acide-folique-ou-acide-folinique-pour-reduire-les-effets-secondaires-du-methotrexate-chez-les-personnes-atteintes-de-polyarthrite-rhumatoide
2013
false
true
false
United Kingdom
France
antirheumatic agents
folic acid
treatment outcome
leucovorin
vitamin B complex
review of literature
french abstract
methotrexate
arthritis, rheumatoid
---
http://www.aboutkidshealth.ca/Fr/HealthAZ/Drugs/Pages/Leucovorin.aspx
http://www.aboutkidshealth.ca/en/healthaz/drugs/pages/leucovorin.aspx?k=leucovorin;+administrer+des+m%c3%a9dicaments
2010
Canada
French
English
leucovorin
child
leucovorin
methotrexate
Drug-Related side effects and adverse reactions
calcium folinate
administration, oral
injections
drug information
patient education handout
---
2008
false
true
false
France
French
IFL protocol
FOLFIRI Regimen
patient education handout
drug information
antineoplastic combined chemotherapy protocols
camptothecin
leucovorin
fluorouracil
---
http://www.has-sante.fr/portail/upload/docs/application/pdf/ct031512.pdf
http://www.has-sante.fr/portail/display.jsp?id=c_399943
2004
false
France
French
Leukovorin rescue (procedure)
injections, intravenous
infusions, intravenous
leucovorin
Drug-Related side effects and adverse reactions
folic acid antagonists
Drug-Related side effects and adverse reactions
detoxifying agents for antineoplastic treatment
antineoplastic agents
evaluation of the transparency committee
---
