Irinotecan - CISMeF

Preferred Label : Irinotecan;

MeSH definition : A semisynthetic camptothecin derivative that inhibits DNA TOPOISOMERASE I to prevent nucleic acid synthesis during S PHASE. It is used as an antineoplastic agent for the treatment of COLORECTAL NEOPLASMS and PANCREATIC NEOPLASMS.;

MeSH synonym : Irrinotecan; Camptothecin-11; Camptothecin 11;

MeSH hyponym : SN-38-11; SN3811; SN-38; CPT11; CPT 11; 7 Ethyl 10 hydroxycamptothecin;

MeSH CAS label : (1,4'-Bipiperidine)-1'-carboxylic acid, (4S)-4,11-diethyl-3,4,12,14-tetrahydro-4-hydroxy-3,14-dioxo-1H-pyrano(3',4':6,7)indolizino(1,2-b)quinolin-9-yl ester;

MeSH Related Number : 042LAQ1IIS; 0H43101T0J;

Registry Number MeSH : 7673326042;

Wikipedia link : https://en.wikipedia.org/wiki/Irinotecan;

UNII : 7673326042;

Details

Origin ID

D000077146;

UMLS CUI

C0123931;

ATC code(s)
- irinotecan [ATC Code]
Allowable qualifiers
- administration and dosage [MeSH Qualifier]
- adverse effects [MeSH Qualifier]
- agonists [MeSH Qualifier]
- analogs and derivatives [MeSH Qualifier]
- analysis [MeSH Qualifier]
- antagonists and inhibitors [MeSH Qualifier]
- blood [MeSH Qualifier]
- cerebrospinal fluid [MeSH Qualifier]
- chemical synthesis [MeSH Qualifier]
- chemistry [MeSH Qualifier]
- classification [MeSH Qualifier]
- economics [MeSH Qualifier]
- history [MeSH Qualifier]
- immunology [MeSH Qualifier]
- isolation and purification [MeSH Qualifier]
- metabolism [MeSH Qualifier]
- pharmacokinetics [MeSH Qualifier]
- pharmacology [MeSH Qualifier]
- poisoning [MeSH Qualifier]
- radiation effects [MeSH Qualifier]
- standards [MeSH Qualifier]
- supply and distribution [MeSH Qualifier]
- therapeutic use [MeSH Qualifier]
- toxicity [MeSH Qualifier]
- urine [MeSH Qualifier]
Automatic exact mappings (from CISMeF team)
- 7-Ethyl-10-Hydroxycamptothecin [NCIt concept]
- Irinotecan [ICD-11 More detail]
- irinotecan [ATC Code]
MeSH indexing information
- prodrugs [MeSH Descriptor]
Pharmacological action(s)
- antineoplastic agents [MeSH Descriptor]
- enzyme inhibitors [MeSH Descriptor]
- topoisomerase I inhibitors [MeSH Descriptor]
Record concept(s)
- 7-ethyl-10-hydroxycamptothecin [MeSH concept]
- CPT-11 [MeSH concept]
- NK012 compound [MeSH concept]
- SN 38 [MeSH concept]
- SN 38 11 [MeSH concept]
- camptosar [MeSH concept]
- irinotecan [MeSH concept]
- irinotecan hydrochloride [MeSH concept]
Related MeSH Supplementary Concept(s)
- LA-SN38 [MeSH Supplementary Concept]
- folfirinox [MeSH Supplementary Concept]
See also inter- (CISMeF)
- Product containing irinotecan (medicinal product) [SNOMED CT concept]
- irinotecan [Pharmacological Root]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
Substance(s)
- irinotecan [Pharmacological Root]

Keyword's position in hierarchy(ies) :

Main resources

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