Preferred Label : UGT1A1 enzyme;

MeSH note : encoded by UGT1 complex which encodes human bilirubin, phenol, and other UDP-glucuronosyltransferase isozymes with identical carboxyl termini; RefSeq NM_000463 (human);

MeSH synonym : UDP-glucuronosyltransferase 1A1; UDP glucuronosyltransferase 1A1; phenol UDP-glucuronosyltransferase; 1-naphthol UDP-glucuronosyltransferase; phenol GCStransferase; bilirubin uridine-diphosphoglucuronosyl transferase 1A1;

MeSH hyponym : UGT1A (bilirubin) enzyme, human; UDP glycosyltransferase 1 family, polypeptide A1, human;

MeSH Related Number : UGT1A1 protein, human; 0RFO7VC96N; EC 2.4.1.-;

Registry Number MeSH : EC 2.4.1.-;

Related CAS MeSH : EC 2.4.1.- (UGT1A1 protein, human);

Is substance : O;

Details


Main resources

You can consult :


https://ansm.sante.fr/informations-de-securite/irinotecan-cancer-colorectal-reduire-la-dose-initiale-chez-les-patients-metaboliseurs-lents-de-lugt1a1-qui-doivent-recevoir-une-dose-dirinotecan-180-mg-m2-ou-qui-ont-une-sante-particulierement-fragile-quelle-que-soit-la-dose
2022
false
false
false
France
French
pharmacovigilance note
Irinotecan
Uridine diphosphate glucuronosyltransferase family 1 member A1 poor metabolizer (finding)
UGT1A1 enzyme
antineoplastic agents
risk management
diarrhea
neutropenia
topoisomerase I inhibitors
Irinotecan
topoisomerase I inhibitors
antineoplastic agents
colorectal neoplasms
UGT1A1*28 Allele
UGT1A1*6 Allele
Irinotecan

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02/05/2025


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