Preferred Label : UGT1A1 enzyme;
MeSH note : encoded by UGT1 complex which encodes human bilirubin, phenol, and other UDP-glucuronosyltransferase
isozymes with identical carboxyl termini; RefSeq NM_000463 (human);
MeSH synonym : UDP-glucuronosyltransferase 1A1; UDP glucuronosyltransferase 1A1; phenol UDP-glucuronosyltransferase; 1-naphthol UDP-glucuronosyltransferase; phenol GCStransferase; bilirubin uridine-diphosphoglucuronosyl transferase 1A1;
MeSH hyponym : UGT1A (bilirubin) enzyme, human; UDP glycosyltransferase 1 family, polypeptide A1, human;
MeSH Related Number : UGT1A1 protein, human; 0RFO7VC96N; EC 2.4.1.-;
Registry Number MeSH : EC 2.4.1.-;
Related CAS MeSH : EC 2.4.1.- (UGT1A1 protein, human);
Is substance : O;
Origin ID : C418331;
UMLS CUI : C0963309;
MeSH term(s) associated for indexing
Record concept(s)
Semantic type(s)
https://ansm.sante.fr/informations-de-securite/irinotecan-cancer-colorectal-reduire-la-dose-initiale-chez-les-patients-metaboliseurs-lents-de-lugt1a1-qui-doivent-recevoir-une-dose-dirinotecan-180-mg-m2-ou-qui-ont-une-sante-particulierement-fragile-quelle-que-soit-la-dose
2022
false
false
false
France
French
pharmacovigilance note
Irinotecan
Uridine diphosphate glucuronosyltransferase family 1 member A1 poor metabolizer (finding)
UGT1A1 enzyme
antineoplastic agents
risk management
diarrhea
neutropenia
topoisomerase I inhibitors
Irinotecan
topoisomerase I inhibitors
antineoplastic agents
colorectal neoplasms
UGT1A1*28 Allele
UGT1A1*6 Allele
Irinotecan
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