Preferred Label : Trastuzumab Deruxtecan;

NCIt synonyms : Fam-trastuzumab Deruxtecan-nxki; WHO 10516; T-DXd;

NCIt definition : An antibody-drug conjugate (ADC) composed of trastuzumab, a monoclonal antibody targeting human epidermal growth factor receptor 2 (ERBB2; EGFR2; HER2) conjugated to deruxtecan, a derivative of the camptothecin analog exatecan (DXd; DX-8951 derivative), a DNA topoisomerase 1 (topoisomerase I; Top1) inhibitor, with antineoplastic activity. Upon administration of trastuzumab deruxtecan, trastuzumab targets and binds to HER2 on tumor cells. Upon antibody/antigen binding and internalization, deruxtecan binds to and inhibits Top1-DNA complexes, which results in an inhibition of DNA replication, cell cycle arrest and tumor cell apoptosis. HER2, a tyrosine kinase receptor, is overexpressed by many cancer cell types. In addition, trastuzumab deruxtecan induces antibody-dependent cell-mediated cytotoxicity (ADCC) and causes a bystander killing effect.;

UNII : 5384HK7574;

CAS number : 1826843-81-5;

Drug name : Enhertu;

Molecule name : DS-8201a; DS-8201;

NCI Metathesaurus CUI : CL509598;

Codes from synonyms : 3590;

Détails


Consulter ci-dessous une sélection des principales ressources :

Vous pouvez consulter :


https://www.has-sante.fr/jcms/p_3530992/fr/enhertu-trastuzumab-deruxtecan-cancer-du-poumon
2024
false
false
false
France
evaluation of the transparency committee
Lung Carcinoma
neoplasm, malignant
Trastuzumab Deruxtecan
lung neoplasms
Trastuzumab Deruxtecan
trastuzumab deruxtecan
lung cancer
trastuzumab
Trastuzumab
trastuzumab deruxtecan

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https://www.ema.europa.eu/en/medicines/human/EPAR/enhertu
2021
false
false
false
Netherlands
French
English
treatment outcome
syndication feed
summary of product characteristics
package leaflet
drug evaluation
Trastuzumab Deruxtecan
Trastuzumab Deruxtecan
drug approval
europe
trastuzumab deruxtecan
Tyrosine Kinase Inhibitors
infusions, intravenous
antineoplastic agents
pregnancy
breast feeding
drug interactions
drug monitoring
adult
breast neoplasms
neoplasm metastasis
Unresectable Breast Carcinoma
aged
receptor, erbB-2
drug evaluation, preclinical
trastuzumab deruxtecan
trastuzumab deruxtecan
antineoplastic agents
camptothecin
immunoconjugates
antibodies, monoclonal, humanized
Trastuzumab
immunoconjugates
antibodies, monoclonal, humanized
Trastuzumab

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Nous contacter.
28/07/2025


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