DNA topoisomerases, type I

Preferred Label : DNA topoisomerases, type I;

MeSH definition : DNA TOPOISOMERASES that catalyze ATP-independent breakage of one of the two strands of DNA, passage of the unbroken strand through the break, and rejoining of the broken strand. DNA Topoisomerases, Type I enzymes reduce the topological stress in the DNA structure by relaxing the superhelical turns and knotted rings in the DNA helix.;

MeSH synonym : topoisomerase i; dna untwisting enzymes; dna nicking-closing proteins; dna relaxing enzymes; dna relaxing enzyme; dna untwisting proteins; dna untwisting protein; type i dna topoisomerase; dna nicking-closing protein; dna relaxing protein; dna topoisomerase i; dna type 1 topoisomerase; dna untwisting enzyme; DNA Topoisomerase;

CISMeF synonym : DNA topoisomerases, type I, eukaryotic; EC 5.99.1.- (DNA topoisomerases, type I, eukaryotic); topoisomerase I, eukaryotic; eukaryotic topoisomerase I; DNA topoisomerase I, eukaryotic; DNA topoisomerases, type I, archaeal; EC 5.99.1.- (DNA topoisomerases, type I, archaeal); topoisomerase 1, archaeal; archaeal topoisomerase 1; DNA topoisomerase 1, archaeal; DNA topoisomerases, type I, bacterial; EC 5.99.1.- (DNA topoisomerases, type I, bacterial); omega protein, topoisomerase I; topoisomerase I, bacterial; bacterial topoisomerase I; DNA topoisomerase I, bacterial;

MeSH hyponym : Topoisomerase IIIbeta; IIIbeta, Topoisomerase; Topoisomerase III beta; III beta, Topoisomerase; beta, Topoisomerase III; III, DNA Topoisomerase; Topoisomerase III, DNA; TOP3 Topoisomerase; Topoisomerase, TOP3; Topo III; III, Topo; Topoisomerase III; III, Topoisomerase; TOPO IIIalpha; IIIalpha, TOPO; Topoisomerase IIIalpha; IIIalpha, Topoisomerase; TOP3alpha;

MeSH CAS label : DNA topoisomerase;

MeSH Related Number : 143180-75-0 (CAS RN);

Registry Number MeSH : EC 5.99.1.2;

MeSH annotation : do not confuse entry term DNA UNTWISTING PROTEIN with DNA UNWINDING PROTEINS see DNA HELICASES; coordinate with BACTERIAL PROTEINS or ARCHAEAL PROTEINS if pertinent;

Is substance : O;

UNII : EC 5.99.1.2;

Details

Origin ID

D004264;

UMLS CUI

C0012920;

Allowable qualifiers
- administration and dosage [MeSH Qualifier]
- adverse effects [MeSH Qualifier]
- analysis [MeSH Qualifier]
- biosynthesis [MeSH Qualifier]
- blood [MeSH Qualifier]
- cerebrospinal fluid [MeSH Qualifier]
- chemical synthesis [MeSH Qualifier]
- chemistry [MeSH Qualifier]
- classification [MeSH Qualifier]
- contraindications [MeSH Qualifier]
- deficiency [MeSH Qualifier]
- drug effects [MeSH Qualifier]
- economics [MeSH Qualifier]
- genetics [MeSH Qualifier]
- history [MeSH Qualifier]
- immunology [MeSH Qualifier]
- isolation and purification [MeSH Qualifier]
- metabolism [MeSH Qualifier]
- pharmacokinetics [MeSH Qualifier]
- pharmacology [MeSH Qualifier]
- physiology [MeSH Qualifier]
- poisoning [MeSH Qualifier]
- radiation effects [MeSH Qualifier]
- standards [MeSH Qualifier]
- supply and distribution [MeSH Qualifier]
- therapeutic use [MeSH Qualifier]
- toxicity [MeSH Qualifier]
- ultrastructure [MeSH Qualifier]
- urine [MeSH Qualifier]
Automatic exact mappings (from CISMeF team)
- DNA Topoisomerase 3-Alpha [NCIt concept]
- DNA Topoisomerase 3-Beta-1 [NCIt concept]
- DNA topoisomerase I [HGNC gene]
- Topoisomerase III [NCIt concept]
- Topoisomerase, dna, I [OMIM gene]
- Topoisomerase, dna, III, alpha [OMIM gene]
- Topoisomerase, dna, III, beta [OMIM gene]
Currated CISMeF NLP mapping
- DNA Topoisomerase 1 [NCIt concept]
False automatic mappings
- Substance with enzyme mechanism of action (substance) [SNOMED CT concept]
Indexing information
- 10,11-methylenedioxy-20-camptothecin [MeSH Supplementary Concept]
- 12,13-dihydro-N-methyl-6,11,13-trioxo-5H-benzo(4,5)cyclohepta(1,2-b)naphthalen-5,12-imine [MeSH Supplementary Concept]
- 2,3-dihydro-9-ethyl-5-fluoro-9-hydroxy-4-methyl-1H,12H-benzo(de)pyrano(3',4'-6,7)indolizino(1,2-b)quinoline-10,13(9H,15H)-dione [MeSH Supplementary Concept]
- 2,3-dimethoxy-8,9-methylenedioxy-11H-indeno(1,2-c)isoquinoline [MeSH Supplementary Concept]
- 2,5-bis(4-hydroxy-3-methoxybenzylidene)cyclopentanone [MeSH Supplementary Concept]
- 2-acyl-5,8-dimethoxy-1,4-naphthoquinone [MeSH Supplementary Concept]
- 2-hydroxy-28-(1H-triazol-1-yl)-lup-1,20(29)-dien-3,28-dione [MeSH Supplementary Concept]
- 28-(1H-triazol-1-yl)-28-oxo-lup-20(29)-en-3-yl-1H-triazole-1-carboxylate [MeSH Supplementary Concept]
- 3,9-dibromo-12-(4-O-methylglucopyranosyl)-6,7.12,13-tetrahydroindolo(2,3-a)pyrrolo(3,4-c)carbazole-5,7-dione [MeSH Supplementary Concept]
- 3-O-(N-(phenylsulfonyl)carbamoyl-17beta-N-(phenylsulfonyl)amide)betulinic acid [MeSH Supplementary Concept]
- 3-O-(glucopyranosyl-1-4-arabinopyranosyl)hederagenin [MeSH Supplementary Concept]
- 3-O-alpha-L-arabinopyranosyl-oleanolic acid [MeSH Supplementary Concept]
- 4,11-dimethoxynaphtho(2,3-f)indole-5,10-dione [MeSH Supplementary Concept]
- 5-ethyl-9,10-difluoro-1,4,5,13-tetrahydro-5-hydroxy-3H,15H-oxepino(3',4'-6,7)indolizino(1,2-b)quinoline-3,15-dione [MeSH Supplementary Concept]
- 5-phenyl-2-(2'-(benzimidazol-5''-yl)benzimidazol-5'-yl)benzimidazole [MeSH Supplementary Concept]
- 5-piperazin-1-ylindeno(1,2-c)isoquinolin-11-one [MeSH Supplementary Concept]
- 6-(3-(2-hydroxyethyl)amino-1-propyl)-5,6-dihydro-2,3-dimethoxy-8,9-methylenedioxy-5,11-dioxo-11H-indeno(1,2-)isoquinoline [MeSH Supplementary Concept]
- 6-acyl-5,8-dimethoxy-1,4-naphthoquinone [MeSH Supplementary Concept]
- 7-butyl-10-amino-camptothecin [MeSH Supplementary Concept]
- 7-butyl-10-amino-camptothecin-beta-alanine-lysine [MeSH Supplementary Concept]
- 7-tert-butyldimethylsilyl-10-hydroxyhomocamptothecin [MeSH Supplementary Concept]
- BE 13793C [MeSH Supplementary Concept]
- BM 2419-1 [MeSH Supplementary Concept]
- BM 2419-2 [MeSH Supplementary Concept]
- CPUY013 compound [MeSH Supplementary Concept]
- Cl-DACA [MeSH Supplementary Concept]
- N,N-bis(3-(5-bromoacridine-4-carboxamido)propyl)methylamine [MeSH Supplementary Concept]
- N,N-bis(3-(5-methylacridine-4-carboxamido)propyl)methylamine [MeSH Supplementary Concept]
- NSC 724998 [MeSH Supplementary Concept]
- NSC 725776 [MeSH Supplementary Concept]
- NSC 743400 [MeSH Supplementary Concept]
- S 38809 [MeSH Supplementary Concept]
- TAN 1496 A [MeSH Supplementary Concept]
- TAN 1496 C [MeSH Supplementary Concept]
- TAN 1496 E [MeSH Supplementary Concept]
- TAN 1518 A [MeSH Supplementary Concept]
- TAN 1518 B [MeSH Supplementary Concept]
- TOPORS protein, human [MeSH Supplementary Concept]
- ardisin [MeSH Supplementary Concept]
- bis-1,3-((5,6-dihydro-5,11-diketo-11H-indeno(1,2-c)isoquinoline)-6-propylamino)propane [MeSH Supplementary Concept]
- bulgarein [MeSH Supplementary Concept]
- cauloside A [MeSH Supplementary Concept]
- cyclohexyl(2-phenylquinazolin-4-yl)amine [MeSH Supplementary Concept]
- dicentrinone [MeSH Supplementary Concept]
- docosyl 4-coumarate [MeSH Supplementary Concept]
- ethyl 7-fluoro-5,12-dioxo-5,12-dihydroindolizino(2,3-g)quinoline-6-carboxylate [MeSH Supplementary Concept]
- indolocarbazole derivative R-6 [MeSH Supplementary Concept]
- isocamptothecin A [MeSH Supplementary Concept]
- isocamptothecin B [MeSH Supplementary Concept]
- kalihinol F [MeSH Supplementary Concept]
- leptosin C [MeSH Supplementary Concept]
- leptosin F [MeSH Supplementary Concept]
- lysyl-cysteinyl-cysteinyl-arginyl-cysteinyl-lysine [MeSH Supplementary Concept]
- norindenoisoquinoline [MeSH Supplementary Concept]
- topopyrone A [MeSH Supplementary Concept]
- topopyrone B [MeSH Supplementary Concept]
- topopyrone C [MeSH Supplementary Concept]
- topopyrone D [MeSH Supplementary Concept]
- topostatin [MeSH Supplementary Concept]
- topostin A1 [MeSH Supplementary Concept]
- topostin A2 [MeSH Supplementary Concept]
- topostin B [MeSH Supplementary Concept]
- tryptophyl-tyrosyl-cysteinyl-arginyl-cysteinyl-lysine [MeSH Supplementary Concept]
Record concept(s)
- DNA Topoisomerase III [MeSH concept]
- DNA Topoisomerase III alpha [MeSH concept]
- DNA Topoisomerase III beta [MeSH concept]
- DNA topoisomerases, type I [MeSH concept]
Related MeSH Supplementary Concept(s)
- Bin4 protein, arabidopsis [MeSH Supplementary Concept]
- DNA reverse gyrase [MeSH Supplementary Concept]
- DNA topoisomerase IB, trypanosoma brucei [MeSH Supplementary Concept]
- DNA topoisomerase V [MeSH Supplementary Concept]
- NikB protein, salmonella typhimurium [MeSH Supplementary Concept]
- TOP1 protein, S cerevisiae [MeSH Supplementary Concept]
- TOP1 protein, human [MeSH Supplementary Concept]
- TOP1MT protein, human [MeSH Supplementary Concept]
- TOP1alpha protein, arabidopsis [MeSH Supplementary Concept]
- TOP1beta protein, arabidopsis [MeSH Supplementary Concept]
- TOP3A protein, human [MeSH Supplementary Concept]
- TOP3B protein, human [MeSH Supplementary Concept]
- Top1mt protein, mouse [MeSH Supplementary Concept]
- Top3B protein, mouse [MeSH Supplementary Concept]
- Top3a protein, mouse [MeSH Supplementary Concept]
- Top3a protein, rat [MeSH Supplementary Concept]
- Top3b protein, rat [MeSH Supplementary Concept]
- gin protein, enterobacteria phage mu [MeSH Supplementary Concept]
- nikA protein, plasmid R64 [MeSH Supplementary Concept]
- scl 70 antigen, human [MeSH Supplementary Concept]
- topA protein, E coli [MeSH Supplementary Concept]
- topB protein, E coli [MeSH Supplementary Concept]
Related MeSH term(s)
- topoisomerase I inhibitors [MeSH Descriptor]
See also
- dna replication [MeSH Descriptor]
See also inter- (CISMeF)
- DNA topoisomerase type I (single strand cut, ATP-independent) activity [GO term]
- DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity [GO term]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- Deoxyribonucleic acid topoisomerase (substance) [SNOMED CT concept]
- dna topoisomerase [SNOMED Notion]
Validated automatic mappings to NTBT
- Deoxyribonucleic acid topoisomerase (substance) [SNOMED CT concept]
- Topoisomerase [NCIt concept]
- dna topoisomerase [SNOMED Notion]

Keyword's position in hierarchy(ies) :

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