Topoisomerase III

Preferred Label : Topoisomerase III;

NCIt synonyms : Topo III; DNA Topoisomerase III; Topoisomerase-III;

NCIt definition : Topoisomerase III belongs to type IA topoisomerases subfamily (includes archaebacterial reverse gyrase, bacterial topo I and topo III, which all form covalent 5'phosphotyrosine linkage with cleaved DNA). Topo III does not play a major role in regulating DNA supercoiling, however, genetic experiments implicate that it plays a role in suppressing mitotic recombination and in resolving recombined homologous chromosomes during meiosis I. Topo III also has been demonstrated to interact with RecQ family of DNA helicases, which includes the Bloom's syndrome, Werner's syndrome, and Rothmund-Thomson syndrome gene products.;

Details

Origin ID

C17340;

UMLS CUI

C0114645;

Automatic exact mappings (from CISMeF team)
- DNA Topoisomerase III [MeSH concept]
- DNA topoisomerases, type I [MeSH Descriptor]
- Topoisomerase, dna, III, alpha [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
gene_encodes_gene_product
- Enzyme Gene [NCIt concept]
- Isomerase Gene [NCIt concept]
gene_product_has_structural_domain_or_motif
- Substrate Interaction Domain [NCIt concept]
gene_product_plays_role_in_biological_process
- DNA Replication [NCIt concept]
- Transcription [NCIt concept]

Keyword's position in hierarchy(ies) :

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