Topoisomerase - CISMeF

Preferred Label : Topoisomerase;

NCIt definition : Enzymes that change the degree of supercoiling in DNA by cutting one or both strands. Type I topoisomerases cut only one strand of DNA; type I topoisomerase of E. coli (omega protein) relaxes negatively supercoiled DNA and does not act on positively supercoiled DNA. Type II topoisomerases cut both strands of DNA; type II topoisomerase of E. coli (DNA gyrase) increases the degree of negative supercoiling in DNA and requires ATP. It is inhibited by several antibiotics, including nalidixic acid and ovobiocin.;

Details

Origin ID

C20646;

UMLS CUI

C1336767;

Automatic exact mappings (from CISMeF team)
- DNA topoisomerase type I (single strand cut, ATP-independent) activity [GO term]
- DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity [GO term]
- DNA topoisomerases, type II [MeSH Descriptor]
Biochemical function of gene products
- Topoisomerase IV [NCIt concept]
See also inter- (CISMeF)
- DNA topoisomerase type I (single strand cut, ATP-independent) activity [GO term]
- DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity [GO term]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
Validated automatic mappings to BTNT
- DNA topoisomerases, type I [MeSH Descriptor]
gene_encodes_gene_product
- Enzyme Gene [NCIt concept]
- Isomerase Gene [NCIt concept]
gene_product_has_structural_domain_or_motif
- Substrate Interaction Domain [NCIt concept]
gene_product_plays_role_in_biological_process
- DNA Replication [NCIt concept]
- Transcription [NCIt concept]

Keyword's position in hierarchy(ies) :

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