Preferred Label : Pegylated Liposomal Irinotecan;
NCIt synonyms : Liposomal Irinotecan;
NCIt definition : A formulation of polyethylene glycol (PEG)-modified liposomes encapsulating the semisynthetic
derivative of camptothecin irinotecan, with antineoplastic activity. As a prodrug,
irinotecan is converted to the biologically active metabolite 7-ethyl-10-hydroxy-camptothecin
(SN-38) by a carboxylesterase-converting enzyme. In turn, SN-38 inhibits topoisomerase
I activity by stabilizing the cleavable complex of topoisomerase I and DNA, resulting
in DNA breaks. This results in an inhibition of DNA replication and an induction of
apoptosis. Pegylated liposomal delivery of irinotecan improves drug penetration into
tumors and decreases drug clearance, thereby increasing the duration of exposure while
lowering systemic toxicity.;
Molecule name : IHL-305;
Origin ID : C62789;
UMLS CUI : C1881411;
Semantic type(s)
Validated automatic mappings to NTBT
chemical_or_drug_affects_gene_product
chemical_or_drug_has_mechanism_of_action
chemical_or_drug_has_physiologic_effect
chemical_or_drug_is_metabolized_by_enzyme
concept_is_in_subset
has_target
https://www.ema.europa.eu/en/medicines/human/EPAR/onivyde-pegylated-liposomal
2021
false
false
false
Netherlands
French
English
treatment outcome
syndication feed
summary of product characteristics
package leaflet
drug evaluation
Metastatic Pancreatic Adenocarcinoma
neoplasm metastasis
Pegylated Liposomal Irinotecan
Pegylated Liposomal Irinotecan
liposomes
pancreatic neoplasms
irinotecan sucrosofate
irinotecan sucrosofate
antineoplastic agents
antineoplastic agents
pregnancy
breast feeding
drug interactions
antineoplastic combined chemotherapy protocols
fluorouracil
leucovorin
Fluorouracil/Liposomal Irinotecan/Leucovorin Regimen
orphan drug production
infusions, intravenous
topoisomerase I inhibitors
topoisomerase I inhibitors
aged
DNA topoisomerases, type I
survival analysis
drug evaluation, preclinical
drug approval
europe
Irinotecan hydrochloride trihydrate (substance)
adult
adenocarcinoma
camptothecin
camptothecin
drug combinations
sucrose
sucrose
camptothecin
drug combinations
sucrose
---
http://www.has-sante.fr/portail/jcms/c_2757888/fr/onivyde
https://www.has-sante.fr/portail/jcms/c_2757888/fr/onivyde-irinotecan-liposomal-pegyle-antineoplasique
2017
false
false
false
France
French
treatment outcome
irinotecan
adult
neoplasm metastasis
pancreatic neoplasms
adenocarcinoma
Metastatic Pancreatic Adenocarcinoma
antineoplastic combined chemotherapy protocols
antineoplastic agents, phytogenic
antineoplastic agents, phytogenic
infusions, intravenous
topoisomerase I inhibitors
topoisomerase I inhibitors
evaluation of the transparency committee
fluorouracil
leucovorin
disease progression
survival analysis
Pegylated Liposomal Irinotecan
guidelines for drug use
camptothecin
Irinotecan
Irinotecan
---