Cytochrome P450 3A7

Preferred Label : Cytochrome P450 3A7;

NCIt synonyms : P450-HFLA; CYPIIIA7; EC 1.14.14.1; Cytochrome-P450-3A7; CYP3A7;

NCIt definition : Cytochrome P450 3A7 (503 aa, 58 kDa) is encoded by the human CYP3A7 gene. This protein plays a role in the oxidation of steroids, fatty acids, and xenobiotics.;

NCIt note : Cytochrome P450 3A7 hydroxylates testosterone and dehydroepiandrosterone 3-sulphate, which is involved in the formation of estriol during pregnancy. (Entrez Gene);

Details

Origin ID

C46000;

UMLS CUI

C0533212;

Currated CISMeF NLP mapping
- CYP3A7 protein, human [MeSH concept]
- CYP3A7 protein, human [MeSH Supplementary Concept]
OMIM relation
- Cytochrome p450, subfamily iiia, polypeptide 7 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- CYP3A7 protein, human [MeSH concept]
- CYP3A7 protein, human [MeSH Supplementary Concept]
enzyme_metabolizes_chemical_or_drug
- Alprazolam [NCIt concept]
- Astemizole [NCIt concept]
- Atorvastatin [NCIt concept]
- Atorvastatin Calcium [NCIt concept]
- Atorvastatin Sodium [NCIt concept]
- Buspirone [NCIt concept]
- Buspirone Hydrochloride [NCIt concept]
- Caffeine [NCIt concept]
- Cerivastatin Sodium [NCIt concept]
- Cilostazol [NCIt concept]
- Cisapride [NCIt concept]
- Clarithromycin [NCIt concept]
- Cyclosporine [NCIt concept]
- Dapsone [NCIt concept]
- Dextromethorphan [NCIt concept]
- Dextromethorphan Hydrobromide [NCIt concept]
- Diazepam [NCIt concept]
- Docetaxel [NCIt concept]
- Domperidone [NCIt concept]
- Erythromycin [NCIt concept]
- Estradiol Acetate [NCIt concept]
- Estradiol Benzoate [NCIt concept]
- Estradiol Cypionate [NCIt concept]
- Estradiol Dipropionate [NCIt concept]
- Estradiol Hemihydrate [NCIt concept]
- Estradiol Monopalmitate [NCIt concept]
- Estradiol Vaginal Ring [NCIt concept]
- Estradiol Valerate [NCIt concept]
- Estriol Sodium Succinate [NCIt concept]
- Ethinyl Estradiol [NCIt concept]
- Felodipine [NCIt concept]
- Fentanyl [NCIt concept]
- Finasteride [NCIt concept]
- Indinavir [NCIt concept]
- Indinavir Anhydrous [NCIt concept]
- Indinavir Sulfate [NCIt concept]
- Irinotecan [NCIt concept]
- Irinotecan Hydrochloride [NCIt concept]
- Lidocaine [NCIt concept]
- Lovastatin [NCIt concept]
- Mestranol [NCIt concept]
- Methadone [NCIt concept]
- Methadone Hydrochloride [NCIt concept]
- Midazolam [NCIt concept]
- Midazolam Hydrochloride [NCIt concept]
- Nelfinavir [NCIt concept]
- Nifedipine [NCIt concept]
- Nisoldipine [NCIt concept]
- Oral Irinotecan Hydrochloride Formulation VAL-413 [NCIt concept]
- Pegylated Liposomal Irinotecan [NCIt concept]
- Polyestradiol Phosphate [NCIt concept]
- Quinidine [NCIt concept]
- Quinine [NCIt concept]
- Ritonavir [NCIt concept]
- Salmeterol [NCIt concept]
- Saquinavir [NCIt concept]
- Simvastatin [NCIt concept]
- Sirolimus [NCIt concept]
- Sodium 17 Beta-Estradiol Sulfate [NCIt concept]
- Tacrolimus [NCIt concept]
- Tamoxifen [NCIt concept]
- Tamoxifen Citrate [NCIt concept]
- Terfenadine [NCIt concept]
- Testosterone Bucyclate [NCIt concept]
- Testosterone Cypionate [NCIt concept]
- Testosterone Enanthate [NCIt concept]
- Testosterone Gel [NCIt concept]
- Testosterone Isobutyrate [NCIt concept]
- Testosterone Ketolaurate [NCIt concept]
- Testosterone Nasal Gel [NCIt concept]
- Testosterone Phenylacetate [NCIt concept]
- Testosterone Propionate [NCIt concept]
- Testosterone Undecanoate [NCIt concept]
- Testosterone Vaginal Cream [NCIt concept]
- Therapeutic Estradiol [NCIt concept]
- Therapeutic Hydrocortisone [NCIt concept]
- Therapeutic Progesterone [NCIt concept]
- Therapeutic Testosterone [NCIt concept]
- Transdermal 17beta-Estradiol Gel BHR-200 [NCIt concept]
- Transdermal Estrogen [NCIt concept]
- Triazolam [NCIt concept]
- Verapamil [NCIt concept]
- Vincristine [NCIt concept]
- Zaleplon [NCIt concept]
gene_encodes_gene_product
- CYP3A7 Gene [NCIt concept]
- Cytochrome P450 Family Gene [NCIt concept]
- Enzyme Gene [NCIt concept]
- Oxidoreductase Gene [NCIt concept]
gene_product_has_chemical_classification
- Heme Protein [NCIt concept]
gene_product_has_organism_source
- Human [NCIt concept]
gene_product_has_structural_domain_or_motif
- Substrate Interaction Domain [NCIt concept]
gene_product_is_element_in_pathway
- Drug Metabolism by Cytochrome P450 Pathway [NCIt concept]
- Drug Metabolism by Non-CYP450 Enzymes Pathway [NCIt concept]
- Fatty Acid Metabolism Pathway [NCIt concept]
- Linoleic Acid Metabolism Pathway [NCIt concept]
- Metabolism of Xenobiotics by Cytochrome P450 Pathway [NCIt concept]
- Retinol Metabolism Pathway [NCIt concept]
- Steroid Hormone Biosynthesis Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Detoxification [NCIt concept]
- Hydroxylation [NCIt concept]
- Intermediary Metabolic Process [NCIt concept]
- Oxidation [NCIt concept]
- Oxidation/Reduction [NCIt concept]
- Steroid Metabolic Process [NCIt concept]
- Xenobiotic Metabolism [NCIt concept]

Keyword's position in hierarchy(ies) :

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